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Review

Structural and Functional Deviations of the Hippocampus in Schizophrenia and Schizophrenia Animal Models

1
Department of Cell Morphology and Molecular Neurobiology, Faculty for Biology and Biotechnology, Ruhr-University Bochum, Universitaetsstr. 150, D-44801 Bochum, Germany
2
Department of Psychiatry, LWL University Hospital, Ruhr-University Bochum, Alexandrinenstr. 1, D-44791 Bochum, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Natalia V. Gulyaeva
Int. J. Mol. Sci. 2022, 23(10), 5482; https://doi.org/10.3390/ijms23105482
Received: 12 April 2022 / Revised: 9 May 2022 / Accepted: 11 May 2022 / Published: 13 May 2022
Schizophrenia is a grave neuropsychiatric disease which frequently onsets between the end of adolescence and the beginning of adulthood. It is characterized by a variety of neuropsychiatric abnormalities which are categorized into positive, negative and cognitive symptoms. Most therapeutical strategies address the positive symptoms by antagonizing D2-dopamine-receptors (DR). However, negative and cognitive symptoms persist and highly impair the life quality of patients due to their disabling effects. Interestingly, hippocampal deviations are a hallmark of schizophrenia and can be observed in early as well as advanced phases of the disease progression. These alterations are commonly accompanied by a rise in neuronal activity. Therefore, hippocampal formation plays an important role in the manifestation of schizophrenia. Furthermore, studies with animal models revealed a link between environmental risk factors and morphological as well as electrophysiological abnormalities in the hippocampus. Here, we review recent findings on structural and functional hippocampal abnormalities in schizophrenic patients and in schizophrenia animal models, and we give an overview on current experimental approaches that especially target the hippocampus. A better understanding of hippocampal aberrations in schizophrenia might clarify their impact on the manifestation and on the outcome of this severe disease.
Keywords: schizophrenia; hippocampus; overexcitability; interneurons; GABA; parvalbumin; perineuronal nets; incomplete inversion patterns; glutamate; extracellular matrix schizophrenia; hippocampus; overexcitability; interneurons; GABA; parvalbumin; perineuronal nets; incomplete inversion patterns; glutamate; extracellular matrix
MDPI and ACS Style

Wegrzyn, D.; Juckel, G.; Faissner, A. Structural and Functional Deviations of the Hippocampus in Schizophrenia and Schizophrenia Animal Models. Int. J. Mol. Sci. 2022, 23, 5482. https://doi.org/10.3390/ijms23105482

AMA Style

Wegrzyn D, Juckel G, Faissner A. Structural and Functional Deviations of the Hippocampus in Schizophrenia and Schizophrenia Animal Models. International Journal of Molecular Sciences. 2022; 23(10):5482. https://doi.org/10.3390/ijms23105482

Chicago/Turabian Style

Wegrzyn, David, Georg Juckel, and Andreas Faissner. 2022. "Structural and Functional Deviations of the Hippocampus in Schizophrenia and Schizophrenia Animal Models" International Journal of Molecular Sciences 23, no. 10: 5482. https://doi.org/10.3390/ijms23105482

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