Molecular Research on Cervical Cancer

Dear Colleagues,

Cervical cancer is the fourth most common cancer in women worldwide. In contrast to most cancers it affects young women with a peak incidence at the age of 40-44 years and as such the consequences for the affected young families are particularly devastating. A prerequisite for cervical cancer is a persistent infection with a high-risk (hr) HPV type of which HPV16 has the highest prevalence among cervical cancer and precursor lesions. Most women acquire one or more hrHPV infections during their lifetime. However, most of these infections are subclinical and resolve spontaneously within several months. This clearly indicates that host and viral factors play a decisive role at all stages of disease progression. Since the discovery of HPV16 and HPV18 in the early 1980s a wealth of studies has contributed to our understanding of the natural history of HPV-infection, the molecular mechanisms of HPV-mediated carcinogenesis, epidemiological aspects, implementation of HPV in primary cancer screening programs and the impact of prophylactic and therapeutic vaccination.

Despite this enormous progress in knowledge the puzzle is by far not complete. Moreover, the use of new technologies not only consolidates and expands on our current knowledge but also raise controversial issues. In this Special Issue on “Cervical Cancer” all contributions related to the aforementioned topics, either as original paper or in form of a review, are highly welcome.

Prof. Dr. Matthias Dürst
Guest Editor

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