Special Issue "Molecular Research on Cervical Cancer"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 September 2019.
Prof. Dr. Matthias Dürst
Department of Gynecology, Jena University Hospital—Friedrich Schiller University Jena, 07747 Jena, Germany
Website | E-Mail
Interests: cervical cancer; cervical intraepithelial lesion; HPV; carcinogenesis; natural history; screening; molecular mechanism; molecular biomarkers; genetic instability; integration; next generation sequencing; vaccination
Cervical cancer is the fourth most common cancer in women worldwide. In contrast to most cancers it affects young women with a peak incidence at the age of 40-44 years and as such the consequences for the affected young families are particularly devastating. A prerequisite for cervical cancer is a persistent infection with a high-risk (hr) HPV type of which HPV16 has the highest prevalence among cervical cancer and precursor lesions. Most women acquire one or more hrHPV infections during their lifetime. However, most of these infections are subclinical and resolve spontaneously within several months. This clearly indicates that host and viral factors play a decisive role at all stages of disease progression. Since the discovery of HPV16 and HPV18 in the early 1980s a wealth of studies has contributed to our understanding of the natural history of HPV-infection, the molecular mechanisms of HPV-mediated carcinogenesis, epidemiological aspects, implementation of HPV in primary cancer screening programs and the impact of prophylactic and therapeutic vaccination.
Despite this enormous progress in knowledge the puzzle is by far not complete. Moreover, the use of new technologies not only consolidates and expands on our current knowledge but also raise controversial issues. In this Special Issue on “Cervical Cancer” all contributions related to the aforementioned topics, either as original paper or in form of a review, are highly welcome.
Prof. Dr. Matthias Dürst
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cervical cancer
- cervical intraepithelial lesion
- natural history
- molecular mechanism
- molecular biomarkers
- genetic instability
- next generation sequencing