Special Issue "Host-Cytomegalovirus Interactions: Pro- and Antiviral Key Factors Affecting CMV Infection Outcome or Therapeutic Approaches"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2019)
Dr. Vera Rebmann
Institute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany
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Interests: NK cell and tumor biology; allotransplantation; immune modulation of T and NK cells; extracellular vesicle; CMV; classical and non-classical HLA molecules; HLA-G; HLA-E; immune checkpoints
Human cytomegalovirus (CMV) is a ubiquitous DNA herpesvirus with a high prevalence. While primary infection usually causes mild symptoms in the healthy population, it can cause severe congenital malformation during pregnancy. Furthermore, life-threatening illnesses can occur upon CMV reactivation particularly in immunocompromised individuals (e.g., AIDS patients and transplant recipients). Recently, CMV has additionally been implicated as a potential co-factor in the pathogenesis of arteriosclerosis, immune senescence and in oncogenesis. Despite the availability of several antiviral agents, CMV remains one of the foremost hazards in the immunocompromised host and a major source of morbidity and sometimes mortality. Thus, the currently available therapeutic options are far from sufficient. Consequently, a great deal of current research is directed towards understanding the molecular biology of viral latency and immune evasion, including host innate and adaptive control of virus reactivation.
The Special Issue is now open to receive manuscripts on all aspects of CMV with particular emphasis on the immunocompromised host.
In this Special Issue, we welcome the submission of mini and full review, original research, short communications, as well as perspectives that cover, but are not limited to, the following topics:
- Mechanisms of protective immunity in acute infection
- Immunological evasion mechanisms of viral latency
- Contributions of specific immune effector cells and mediators of infection control
- Immunopathology of acute or latent infection
- Predisposing genetic host mechanism associated with CMV infection
- Vaccine approaches and new (immune) therapeutical strategies
- Mechanisms of innate immune system in the generation of specific immunity
- Biomarkers and immune surveillance strategies in CMV infection
Dr. Vera Rebmann
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- immune evasion mechanisms
- immune surveillance mechanisms
- acute and latent CMV infection
- vaccine approaches
- genetic predisposition
- innate mediators of infection control
- immunocompromised host
- animal models