Special Issue "Basal Cell Carcinoma"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2017).
Interests: dermato-oncology; melanoma; non-melanoma skin cancer; dermoscopy; immune-mediated diseases
Basal cell carcinoma (BCC) is a slow-growing, locally-invasive malignant epidermal skin neoplasm that represents the most common malignancy in Caucasians, accounting for around 80% of all non-melanoma skin cancers, and its incidence is still on the rise worldwide. The clinical presentation of BCC can be extremely variable and the knowledge of defined high-risk clinico-pathological subtypes of BCC with different biologic behavior is required for appropriate clinical management of patients. The improvement of non-invasive diagnostic techniques, such as dermoscopy and the introduction of in vivo reflectance confocal microscopy, have allowed to increase the accuracy in the early identification of BCC aggressive variants, guiding clinician in decision-making regarding the need and suitability of various treatment strategies. The therapeutic armamentarium ranges from medical treatments and photodynamic therapy for low risk BCC, to surgical excision and radiation therapy for high risk BCC. In last years, molecular and genetic studies have shown that almost all BCC contain genetic alterations in the hedgehog signaling pathway, resulting in aberrant activation with uncontrolled proliferation and making it an optimal target for novel therapies. Thus, recently, novel therapeutic options are also available for the treatment of locally advanced and metastatic BCC that are not eligible for surgery or radiotherapy, consisting in small molecules that inhibit pathogenetic pathways. This Special Issue of IJMS gives insight in the evolving field of BCC regarding research, diagnosis, treatment modalities and clinical applications.
Dr. Ketty Peris
Dr. Alessandro Di Stefani
Manuscript Submission Information
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- skin neoplasm
- non-melanoma skin cancer
- basal cell carcinoma
- BCC pathogenesis
- diagnostic techniques
- reflectance confocal microscopy
- target therapy