Role and Application of Stem Cells in Regenerative Medicine (Volume 5)

Dear Colleagues, 

This Special Issue is the fifth version of our previous Special Issue "Role and Application of Stem Cells in Regenerative Medicine”. 

https://www.mdpi.com/journal/ijms/special_issues/stem_cells_med 

https://www.mdpi.com/journal/ijms/special_issues/stem_cells_med2 

https://www.mdpi.com/journal/ijms/special_issues/stem_cells_med3

https://www.mdpi.com/journal/ijms/special_issues/59769A8GJ0 

Mesenchymal stem cells (MSCs) are currently being used in preclinical and clinical trials for their ability to promote wound healing and tissue regeneration. 

In particular, oral-derived mesenchymal stem cells (oral-MSCs) are accessible and can be collected and used in regenerative medicine, avoiding ethical concerns. They can be derived from different oral tissues, such as human exfoliated deciduous teeth (SHED), periodontal ligaments (PDLSCs), dental follicles (as progenitor (P) cells, DFPCs), apical papilla (SCAP), dental pulp (DPSCs), and gingival tissue (GMSCs), and possess multipotential properties and high proliferation and differentiation abilities. Moreover, oral MSCs have paracrine and immunomodulatory capacities, representing an innovative tool for the treatment of various degenerative and traumatic processes, including skeletal and maxilla-facial degeneration, trauma or ischemia injuries, and neurodegenerative and immune disorders. 

This new Special Issue will comprise a selection of research papers and reviews contributing to the evaluation of the aptitude of oral-MSCs and their secretome for tissue regeneration, thereby facilitating the fabrication of 3D living constructs for future clinical applications. 

Moreover, in vitro and in vivo studies on the molecular mechanisms involved in tissue regeneration are of interest, since they will provide a possibly important contribution to the development of stem-cell-based regeneration strategies and to the identification of key biological regulation processes that remain uncovered.

Prof. Dr. Oriana Trubiani
Dr. Francesca Diomede
Dr. Jacopo Pizzicannella
Guest Editors

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