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Biomaterials for Wound Healing and Tissue Regeneration
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Biomaterials for Wound Healing and Tissue Regeneration

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (20 February 2025) | Viewed by 2101

Special Issue Editor

Prof. Dr. Chan Yeong Heo

E-Mail Website
Guest Editor
1. Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea
2. Department of Plastic & Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea
Interests: soft tissue filler; soft tissue reconstruction; stem cell research; hydrogel

Special Issue Information

Dear Colleagues,

The dynamic field of biomaterials stands at the confluence of cutting-edge molecular science and transformative medical therapies, particularly in the realms of wound healing and tissue regeneration. This Special Issue, titled "Biomaterials for Wound Healing and Tissue Regeneration", aims to encapsulate the breadth and depth of contemporary research and innovation within this vital area. We invite contributions that delve into the molecular intricacies of biomaterials design, synthesis, and application, with a keen focus on their interaction with biological systems at the cellular and molecular levels. Emphasis will be placed on novel biomaterials that show promise in enhancing tissue repair and regeneration, their mechanisms of action, bio-integration, and the modulation of cellular responses crucial for effective healing processes. Additionally, we welcome submissions describing clinical research that bridge the gap between laboratory discoveries and patient care, illustrating the practical applications of biomaterials in real-world medical settings. This Special Issue seeks to highlight both fundamental and applied research, charting the future direction of this pivotal field.

This Special Issue is supervised by Prof. Dr. Chan Yeong Heo and assisted by Dr. Joseph Kyu-hyung Park (Seoul National University Bundang Hospital).

Prof. Dr. Chan Yeong Heo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • wound healing
  • tissue regeneration
  • bio-integration
  • novel therapies
 

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Published Papers (2 papers)

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Research

23 pages, 8837 KiB  
Article
Supercritical Carbon Dioxide-Processed Acellular Dermal Matrix Patch for Enhanced Wound Healing
by Xinrui Zhang, Linh Thi Thuy Le, Yongxun Jin, Caijun Jin, Nguyen Ngan Giang, Thuy-Tien Thi Trinh, Yong Hyun Lee, Yong Woo Shin, Jin Woo Bae, Pham Ngoc Chien and Chan Yeong Heo
Int. J. Mol. Sci. 2025, 26(12), 5715; https://doi.org/10.3390/ijms26125715 - 14 Jun 2025
Viewed by 702
Abstract
Wound healing remains a significant clinical challenge worldwide, and effective management strategies are essential for improving outcomes. This study evaluated SCderm Matrix, a novel acellular dermal matrix (ADM) patch developed using supercritical carbon dioxide (sCO2) processing of human skin tissue. This [...] Read more.
Wound healing remains a significant clinical challenge worldwide, and effective management strategies are essential for improving outcomes. This study evaluated SCderm Matrix, a novel acellular dermal matrix (ADM) patch developed using supercritical carbon dioxide (sCO2) processing of human skin tissue. This innovative processing method preserves structural integrity while enhancing biocompatibility, resulting in a patch characterized by porous architecture, uniform thickness, excellent tensile strength, and optical transparency. In vivo wound healing experiments using full-thickness skin wounds in Sprague–Dawley rats demonstrated the patch’s superior performance. Treatment with the sCO2 ADM patch accelerated wound closure, reduced inflammation, and enhanced granulation tissue formation compared to both untreated controls and two commercially available ADM products. Histological analysis revealed improved re-epithelialization and collagen deposition, while molecular and immunohistochemical assessments showed decreased reactive oxygen species (ROS) and pro-inflammatory cytokines. Simultaneously, the treatment upregulated key proliferation and remodeling markers including alpha smooth muscle actin (α-SMA), vimentin, and transforming growth factor beta 1 (TGF-β1). These findings demonstrate that the SCderm Matrix promotes wound healing through multiple mechanisms: modulating inflammatory responses, enhancing antioxidant defenses, and supporting tissue regeneration. The results suggest this biomaterial has significant potential as an effective and versatile solution for clinical wound care applications. Full article
(This article belongs to the Special Issue Biomaterials for Wound Healing and Tissue Regeneration)
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15 pages, 2256 KiB  
Communication
Comparative Study of Placental Allografts with Distinct Layer Composition
by Pragya Singh, Acarizia Easley, Karla Tapia Menchaca, Victor Fanniel, Raymond Gomez, Joanna Marquez and Shauna Hill
Int. J. Mol. Sci. 2025, 26(7), 3406; https://doi.org/10.3390/ijms26073406 - 5 Apr 2025
Viewed by 906
Abstract
Human placental-derived allografts are biomaterials categorized as cellular, acellular, matrix-like products (CAMPs) that can serve as wound coverings due to placenta tissue’s innate barrier function. The placental membrane consists of three layers, the amnion, the intermediate layer (IL), and the chorion, each contributing [...] Read more.
Human placental-derived allografts are biomaterials categorized as cellular, acellular, matrix-like products (CAMPs) that can serve as wound coverings due to placenta tissue’s innate barrier function. The placental membrane consists of three layers, the amnion, the intermediate layer (IL), and the chorion, each contributing distinct functional and biological properties. This study investigates how variations in layer composition influence the Extracellular Matrix (ECM) and growth factor profiles of placental allografts. We compared Dual Layer (amnion–amnion), Full Thickness (amnion–intermediate–chorion, FT), and a novel four-layer allograft configuration (amnion–intermediate–chorion–amnion, ACA). Histological analyses using hematoxylin and eosin (H&E) and Masson’s trichrome staining revealed distinct structural architecture among the three allografts, with FT and ACA exhibiting 4.9 times and 5.7 times greater thickness as compared with the Dual Layer, respectively. Compositional studies revealed different concentrations of key ECM components (collagen, elastin, proteoglycans, hyaluronic acid) and growth factors (ANG-2, EGF, PDGF-AA, VEGF) across allografts. The collagen concentration was two times higher in ACA as compared with the Dual Layer and FT. Additionally, FT and ACA demonstrated higher levels of growth factors and other ECM components, underscoring their biochemical diversity. These findings highlight the fact that the structural and biochemical properties of placental-derived allografts depend on their layer composition. This study underscores the importance of tailoring layer configurations that are optimized for clinical applications of CAMPs, enabling clinicians to select the most suitable grafts for clinical use, such as for wound management. Full article
(This article belongs to the Special Issue Biomaterials for Wound Healing and Tissue Regeneration)
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