Sleep Apnea and Intermittent Hypoxia 4.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 May 2024 | Viewed by 1859
Special Issue Editor
Interests: diabetes and its complication; sleep apnea; cancer cell biology; CD38-cyclic ADP-ribose signal system; insulin secretion; regeneration biology; regenerating gene (Reg) family
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issues “Sleep Apnea and Intermittent Hypoxia”, “Sleep Apnea and Intermittent Hypoxia 2.0” and “Sleep Apnea and Intermittent Hypoxia 3.0”.
Sleep apnea syndrome (SAS) is a clinical syndrome characterized by repeated episodes of pharyngeal obstruction during sleep that leads to intermittent hypoxia (IH), sleep fragmentation, and excessive daytime sleepiness. It is a highly prevalent disorder, affecting about 14% of men and 5% of women, and its prevalence is rapidly rising because of its strong association with obesity. The major health burden in SAS patients is an increased risk of cardiovascular diseases, such as systemic arterial hypertension, coronary artery disease, heart failure, and stroke, which is an association that is corroborated by numerous large-scale epidemiological and prospective studies. Furthermore, there is increasing evidence of an independent association of SAS with metabolic dysfunction, and in particular, with alterations in glucose metabolism. Subjects with SAS seem to be at a greater risk of developing type 2 diabetes mellitus, insulin resistance, and metabolic syndrome, an association that seems to be, at least in part, irrespective of the degree of obesity. Indeed, SAS and obesity may exert synergistic negative effects on glucose metabolism. However, there are few molecular studies about SAS/IH. The aim of this Special Issue is to provide new findings regarding the molecular events in SAS/IH, as well as their mechanisms.
Prof. Dr. Shin Takasawa
Guest Editor
Manuscript Submission Information
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Keywords
- sleep apnea syndrome
- intermittent hypoxia
- oxidative stress
- gene expression
- diabetes
- appetite
- obesity
- hypertension
