Special Issue "Sleep Apnea and Intermittent Hypoxia"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 July 2019).
Prof. Dr. Shin Takasawa
Department of Biochemistry, Nara Medical University (NMU), 840Shijo-cho, Kashihara 634-8521, Nara, Japan
Interests: diabetes and its complication; sleep apnea; cancer cell biology; CD38-cyclic ADP-ribose signal system; insulin secretion; regeneration biology; regenerating gene (Reg) family
Sleep apnea syndrome (SAS) is a clinical syndrome characterized by repeated episodes of pharyngeal obstruction during sleep, that leads to intermittent hypoxia (IH), sleep fragmentation, and excessive daytime sleepiness. It is a highly prevalent disorder affecting about 14% of men and 5% of women, and its prevalence is rapidly rising because of the strong association of SAS with obesity. The major health burden in SAS patients is an increased risk of cardiovascular diseases, such as systemic arterial hypertension, coronary artery disease, heart failure, and stroke, which is an association that is corroborated by numerous large-scale epidemiological and prospective studies. Furthermore, there is increasing evidence of an independent association of SAS with metabolic dysfunction, and in particular, with alterations in glucose metabolism. Subjects with SAS seem to be at greater risk of developing type 2 diabetes mellitus, insulin resistance, and metabolic syndrome, an association that seems to be, at least in part, irrespective of the degree of obesity. Indeed, SAS and obesity may exert synergistic negative effects on glucose metabolisms. However, there are few molecular studies about SAS/IH. The aim of this Special Issue is to provide new findings regarding the molecular events in SAS/IH, as well as their mechanisms.
Prof. Dr. Shin Takasawa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Sleep apnea syndrome
- Intermittent hypoxia
- Oxidative stress
- Gene expression