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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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AI and Neurogenomics: Innovations in Precision Medicine for Brain Disorders

edited by

Stefania Zampatti

and

Emiliano Giardina

submission deadline 5 Sep 2026 | 3 articles | Viewed by 6487 | Submission Open

Keywords: neurogenetics; genomics; artificial intelligence; brain disorders; neurodegenerative disease

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Epigenetic Dynamics in Cancer and Aging

edited by

Hayan Lee

submission deadline 10 Sep 2026 | 1 articles | Viewed by 2047 | Submission Open

Keywords: DNA methylation; histone modification; chromatin 3D modeling; non-coding RNA; long-read sequencing technology; single-cell epigenetics; cancer initiation and development; epigenetic alterations in the aging process; aging-specific epigenetic alterations; cancer-specific epigenetic alterations

(This special issue belongs to the Section Epigenomics)

Genetic Architecture of Wheat Domestication- and Improvement-Related Traits

edited by Panfeng Guan

submission deadline 10 Sep 2026 | 1 articles | Viewed by 981 | Submission Open

Keywords: wheat; origin and evolution; domestication syndrome; genetic diversity; genetic improvement; gene mapping and cloning; molecular mechanism and function; molecular breeding; pan-omics; new approaches

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics of Neuromuscular Disorders

edited by Nyamkhishig Sambuughin

submission deadline 10 Sep 2026 | Viewed by 349 | Submission Open

Keywords: hereditary neuromuscular disorders; functional studies; disease mechanisms; variant pathogenicity; animal and cell culture model of neuromuscular disorders

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Epigenetic Landscape of Neurodevelopmental Disorders

edited by Bimal Jana

submission deadline 10 Sep 2026 | Viewed by 309 | Submission Open

Keywords: epigenetics; neurodevelopmental disorders (NDDs); DNA methylation; 3D genome architecture; histone modifications; non-coding RNA; autism spectrum disorder (ASD); Rett syndrome; neurodevelopment; gene-environment interaction; epigenetic biomarkers; single-cell epigenomics; epigenetic therapy

(This special issue belongs to the Section Neurogenomics)

The Roles of Epigenetic Mechanisms in Neurological and Brain Diseases and Therapeutics

edited by Zahra Farzinpour

submission deadline 10 Sep 2026 | Viewed by 254 | Submission Open

Keywords: neuroepigenetics; histone modifications; non-coding RNAs; epigenetic biomarkers; novel therapeutics; non-opioid therapy; addiction; chronic pain; depression; stress

(This special issue belongs to the Section Epigenomics)

Genetics and Genomics of Endocrine Diseases in Children and Adolescents

edited by

Malgorzata Wasniewska

submission deadline 15 Sep 2026 | 3 articles | Viewed by 7072 | Submission Open

Keywords: endocrine disease; endocrine gland; genetic syndrome; genetic polymorphism; genetic pathomechanism

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Host–Pathogen Interactions

edited by

Transito Garcia-Garcia

and Sara Zaldívar López

submission deadline 15 Sep 2026 | 2 articles | Viewed by 3169 | Submission Open

Keywords: pathogen virulence factors; infection susceptibility; immune evasion; genomics of infectious diseases; host–pathogen co-evolution; host–pathogen dynamics; microbiome–host interactions; emerging infectious diseases; crispr and gene editing in host–pathogen studies; transcriptomics and gene expression profiling

(This special issue belongs to the Section Molecular Genetics and Genomics)

Reviews in RNA: Mechanisms and Roles

edited by

Laurent Metzinger

and

Valérie Metzinger-Le Meuth

submission deadline 15 Sep 2026 | 3 articles | Viewed by 2848 | Submission Open

Keywords: gene regulation; non-coding RNA; RNA world; RNA-related metabolism

(This special issue belongs to the Section RNA)

RNA Biology and Diseases

edited by Sharon Moshitch-Moshkovitz

submission deadline 15 Sep 2026 | 3 articles | Viewed by 2718 | Submission Open

Keywords: mechanisms of RNA processing; RNA modification and epitranscriptomics; regulatory RNAs; RNA-based therapy (ASOs, targeted modifications); RNA–protein interactions; non-coding RNAs and diseases; post-translational modifications in shaping the epitranscriptome; RNA structures and restructuring mechanisms

(This special issue belongs to the Section RNA)

New Updates in the Area of Pig Genomics and Genetics

edited by

Katarzyna Piórkowska

submission deadline 15 Sep 2026 | 2 articles | Viewed by 1377 | Submission Open

Keywords: pig breeding; pig molecular genetics; genome-editing technologies; CRISPR/Cas9; functional genomics; transcriptomics; epigenomics; non-coding RNAs

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic and Epigenetic Architecture of Complex Cardiovascular Traits

edited by

Samantha L. Manna

and Mariana Bezamat Chappel

submission deadline 15 Sep 2026 | 1 articles | Viewed by 795 | Submission Open

Keywords: cardiovascular disease; genetics/genomics; epigenetics/epigenomics; omics; precision medicine; genotype–phenotype correlations; gene–gene interactions

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

RNA Interference—Small RNAs in Biomedicine

edited by

Tamas Orban

submission deadline 15 Sep 2026 | Viewed by 500 | Submission Open

Keywords: RNAi; miRNA; siRNA; piRNA; extracellular vesicle; vesicular miRNA; biofluids; blood miRNA; serum miRNA; urine miRNA; saliva miRNA; miRNA therapy; siRNA therapy

(This special issue belongs to the Section RNA)

Mitochondrial DNA Variation in Health and Disease

edited by Ludmiła A. Grzybowska-Szatkowska, Katarzyna Bartosik and Marzanna Ciesielka

submission deadline 15 Sep 2026 | Viewed by 353 | Submission Open

Keywords: mitochondrial DNA; single-nucleotide polymorphism; carcinogenesis; apoptosis; mitochondrial haplogroups

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genomic and Epigenomic Mechanisms in the Environmental Regulation of Stress-Related Neuropsychiatric Disorders

edited by

Richard Hunter

submission deadline 15 Sep 2026 | Viewed by 315 | Submission Open

Keywords: gene–environment interaction; behavioral genomics; social science genomics; behavioral genetics; stress-related aging; PTSD; depression; individual vulnerability

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomic Insights into Animal Evolution: From Phylogeny to Adaptation

edited by

Baosheng Wu

and Chenguang Feng

submission deadline 15 Sep 2026 | Viewed by 246 | Submission Open

Keywords: comparative genomics; evolutionary developmental biology (Evo-Devo); molecular adaptation; regulatory evolution; animal phylogeny; genotype–phenotype mapping

(This special issue belongs to the Section Animal Genetics and Genomics)

Canine Genomics and Disease Research

edited by

Jeffrey Kidd

submission deadline 20 Sep 2026 | 1 articles | Viewed by 6930 | Submission Open

Keywords: canine genetics; trait mapping; genome structure and function; population genetics; association studies; canine evolution; canine disease

(This special issue belongs to the Section Animal Genetics and Genomics)

Advances in Prenatal and Postnatal Genetic Testing: Precision Diagnosis for Genetic Disorders

edited by

Spiros Vittas

and Eirini Louizou

submission deadline 20 Sep 2026 | 4 articles | Viewed by 3829 | Submission Open

Keywords: genetic testing; prenatal diagnosis; postnatal diagnosis; precision medicine

(This special issue belongs to the Section Genetic Diagnosis)

New Insight into the Genetic and Molecular Aspects of Yeast Nutrient Metabolism

edited by Roman Maslanka and

Renata Zadrag-Tecza

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1274 | Submission Open

Keywords: yeasts as a model organism; yeast metabolism; nutrient sensing; sugar/hexose transport; central carbon metabolism; catabolite repression; nutrient availability; resource allocation; calorie restriction; cAMP-PKA signaling; metabolic flux; metabolic adaptation; genetic and transcriptional regulation; cellular homeostasis; molecular biology of yeast

(This special issue belongs to the Section Molecular Genetics and Genomics)

Clinical Research Advances in Pharmacogenetics and Pharmacogenomics

edited by Martina Hahn

submission deadline 20 Sep 2026 | 1 articles | Viewed by 943 | Submission Open

Keywords: pharmacogenetics; pharmacogenomics; personalized medicine; gender medicine; genetic testing; drug response; therapeutic outcomes; adverse drug reactions; clinical research; genetic markers; precision therapeutics

(This special issue belongs to the Section Pharmacogenetics)

Horticultural Functional Genomics and Breeding

edited by

Hanqiang Liu

submission deadline 20 Sep 2026 | 1 articles | Viewed by 526 | Submission Open

Keywords: functional genomics; multi-omics integration; epigenetic regulation; gene regulatory networks; forward genetics; GWAS; genome engineering; molecular breeding; precision breeding; trait dissection

(This special issue belongs to the Section Plant Genetics and Genomics)

Wheat Genomic Study

edited by

Xiaoyan Li

submission deadline 20 Sep 2026 | Viewed by 336 | Submission Open

Keywords: Triticum aestivum; pangenome; QTL mapping; GWAS; stress tolerance; yield; genomic selection; breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Mechanisms and Therapeutics in Autism: From Genes to Clinical Practice

edited by Iliyana Pacheva

submission deadline 20 Sep 2026 | Viewed by 247 | Submission Open

Keywords: autism; autistic spectrum disorder; epilepsy and autism; pathogenesis; mitochondrial dysfunction; inflammation; genes and autism; comorbidities; biomarkers; precise medicine; treatment

(This special issue belongs to the Section Neurogenomics)

Physiological and Molecular Mechanisms of Plant Stress Response

edited by

Yakupjan Haxim

submission deadline 25 Sep 2026 | 4 articles | Viewed by 5866 | Submission Open

Keywords: drought stress; heat stress; cold stress; salinity stress; pathogen infection; multi-omic approaches; gene expression; plant resistance

(This special issue belongs to the Section Plant Genetics and Genomics)

The Genetic Lens: A New Era in Ophthalmology

edited by

Stefania Zampatti

and

Emiliano Giardina

submission deadline 25 Sep 2026 | 4 articles | Viewed by 4537 | Submission Open

Keywords: ophthalmology; genomics; artificial intelligence; inherited retinal disease; blindness

(This special issue belongs to the Section Genetic Diagnosis)

Epigenetic Regulation in Tumors

edited by

Anca Botezatu

submission deadline 25 Sep 2026 | 2 articles | Viewed by 4009 | Submission Open

Keywords: cancer epigenetics; epigenetic mechanisms; tumor microenvironment; epigenetic biomarkers; multi-omics and bioinformatics

(This special issue belongs to the Section Epigenomics)

Livestock Germplasm Resources, Genetics, and Breeding

edited by

Enrico D’ Alessandro

and Marco Tolone

submission deadline 25 Sep 2026 | 2 articles | Viewed by 1961 | Submission Open

Keywords: animal genetics; genomics; animal production; metagenomics; genome-wide association study (GWAS); product quality; fertility; health; coat color; molecular traceability; biodiversity

(This special issue belongs to the Section Animal Genetics and Genomics)

Gene-Regulated Signaling Pathways in Cancer

edited by Alexander Damalas

submission deadline 25 Sep 2026 | 1 articles | Viewed by 1314 | Submission Open

Keywords: caveolin-1 (CAV1); caveolae; Ras; EMT; invasion; MAPK; PI3K-Akt; membrane curvature (MC)

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Epigenetic Drivers of Lung Cancer Heterogeneity and Therapy Resistance

edited by Maria Palmieri and Viola Bianca Serio

submission deadline 25 Sep 2026 | 1 articles | Viewed by 572 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); intratumor heterogeneity; acquired resistance; DNA methylation; histone modifications; non-coding RNAs (ncRNAs); epithelial–mesenchymal transition (EMT); single-cell sequencing; liquid biopsy; targeted therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Mechanisms of Obesity

edited by

Thangiah Geetha

submission deadline 25 Sep 2026 | Viewed by 513 | Submission Open

Keywords: obesity; genetic mechanisms; epigenetics; DNA methylation; genome-wide association studies; multi-omics; transcriptomics; foundtional genomics; gene–environment interactions; childhood obesity; energy metabolism; precision medicine; gut microbiota

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Epigenetic Control of Animal Reproduction and Key Traits

edited by

Enqi Liu

submission deadline 25 Sep 2026 | Viewed by 464 | Submission Open

Keywords: animal reproduction; epigenetics; spermatogenesis; oogenesis; heterosis; transgenerational inheritance; early embryonic development; DNA methylation; histone modification; non-coding RNA; chromatin remodeling; genomic imprinting; molecular breeding; genomic imprinting; economic traits

(This special issue belongs to the Section Animal Genetics and Genomics)

Cytogenetics and Cytogenomics in Clinical Diagnostics: Innovations and Applications—2nd Edition

edited by

Jinglan Liu

submission deadline 25 Sep 2026 | Viewed by 427 | Submission Open

Keywords: karyotyping; cytogenomics; chromosome territory (CT); nuclear architecture; clinical oncology; germline; development; neuropsychiatric; artificial intelligence (AI)

(This special issue belongs to the Section Cytogenomics)

Genomic Mutations and Susceptibility in Breast Cancer

edited by Balaji Virassamy

submission deadline 25 Sep 2026 | Viewed by 307 | Submission Open

Keywords: genetic variants; somatic mutation landscape; morphological variation; oncogenic timing; next-generation sequencing; targeted therapies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomic Responses to Rapid Environmental Change in Biodiversity Hotspots

edited by Diana Daniela Moreno-Santillan and Diana Aguilar Gomez

submission deadline 25 Sep 2026 | Viewed by 263 | Submission Open

Keywords: population genetics; phylogenetics; adaptation; environmental change; conservation genetics

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Corn Breeding for Disease Resistance

edited by Xuanjun Feng

submission deadline 25 Sep 2026 | Viewed by 236 | Submission Open

Keywords: maize; disease resistance; corn breeding; resistance gene; QTL mapping; genomic-assisted breeding; gene functional analysis; plant–pathogen interaction; genetic diversity; molecular genetics; crop genetic improvement; cereal crop

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics, Breeding and Genomic Improvement of Aquaculture Fish

edited by Tianqing Huang

submission deadline 25 Sep 2026 | Viewed by 224 | Submission Open

Keywords: aquaculture; fish breeding; genetics; polyploidy; molecular biology; gonadal development

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Aspects of Autoimmune Diseases

edited by Cheuk Wun Li

submission deadline 10 Oct 2026 | 7 articles | Viewed by 10659 | Submission Open

Keywords: autoimmune diseases; genetics; genetic variants; polygenic; therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Abiotic Stress in Crop: Molecular Genetics and Genomics

edited by Xuke Lu

submission deadline 10 Oct 2026 | 4 articles | Viewed by 2213 | Submission Open

Keywords: plants; abiotic stresses; molecular mechanism; differentially expressed genes (DEGs); regulatory network

(This special issue belongs to the Section Plant Genetics and Genomics)

Sperm DNA Changes: Causes, Diagnostics, and Implications for Fertility and Offspring Health

edited by

Jonatan Axelsson

and

Humaira Gowher

submission deadline 10 Oct 2026 | 1 articles | Viewed by 1406 | Submission Open

Keywords: sperm DNA; sperm DNA fragmentation; germ cell mutations; de novo mutations; offspring effects; infertility; sperm chromatin structure; epigenetics; lifestyle; environmental effects; error-corrected sequencing; aneuploidy; chromosome aberrations; pregnancy; child

(This special issue belongs to the Section Genetic Diagnosis)

Identifying Fertility Biomarkers Using Omics Approach

edited by

Muhammet Rasit Ugur

submission deadline 10 Oct 2026 | 1 articles | Viewed by 1151 | Submission Open

Keywords: fertility; infertility; biomarker; omics; multi-omics; genomics; transcriptomics; proteomics; metabolomics; epigenomics; lipidomic; microbiomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genome Sequencing and Genetic Testing for Cancer

edited by

Kapila Gunasekera

submission deadline 10 Oct 2026 | 1 articles | Viewed by 880 | Submission Open

Keywords: next-generation sequencing (NGS); precision oncology; liquid biopsy and ctDNA; whole-genome sequencing (WGS); cancer susceptibility genes; somatic mutation profiling; pharmacogenomics; machine learning and AI in omics; multi-omics integration; biomarker discovery; targeted therapy; molecular diagnostics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Utilizing Animal Disease Models to Understand Human Genetics

edited by

Tiziana Orsini

submission deadline 10 Oct 2026 | 1 articles | Viewed by 543 | Submission Open

Keywords: animal models of human disease; genotype-phenotype correlation; functional genomics; developmental biology; translational genetics; variant validation; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Cancer Driver Mutations and Tumor Evolution

edited by Yusi Fu

submission deadline 10 Oct 2026 | Viewed by 266 | Submission Open

Keywords: driver mutations; tumor evolution; clonal dynamics; intratumor heterogeneity; somatic mosaicism; single-cell genomics; mutational signatures; clonal hematopoiesis; tumor microenvironment

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Diagnosis, Management and Therapy of Rare Diseases

edited by Giorgia Girotto

submission deadline 15 Oct 2026 | 8 articles | Viewed by 9975 | Submission Open

Keywords: rare and ultrarare genetic diseases; genetic mechanisms; gene-tailored management; personalized therapeutic approaches

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Morphological Diversity in Plants

edited by

P. Roxanne Kellar

submission deadline 15 Oct 2026 | 7 articles | Viewed by 9273 | Submission Open

Keywords: biodiversity; conservation; genetic structure; genetics; genotype; germplasm; haplotype; high-throughput sequencing; invasive species; microsatellites; molecular markers; morphological characters; morphology; morphometrics; morphotype; next-generation sequencing; phenotype; systematics; taxonomy; variation

(This special issue belongs to the Section Plant Genetics and Genomics)

The Function and Molecular Mechanism for Immune Responses in Human Diseases

edited by Zsofia Banlaki

submission deadline 15 Oct 2026 | 5 articles | Viewed by 4779 | Submission Open

Keywords: leukocyte; cytokine; immune receptor; signal transduction; gene expression; antibody-antigen; major histocompatibility complex; complement system; inflammation

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Epigenetic Factors for Autoimmune Diseases

edited by

Ulises De La Cruz-Mosso

submission deadline 15 Oct 2026 | 2 articles | Viewed by 4624 | Submission Open

Keywords: single nucleotide variants; polymorphism; mutations; microRNAs; HLA genes; cytokine gene; DNA methylation; rheumatoid arthritis; systemic lupus erythematosus; exposome

(This special issue belongs to the Section Epigenomics)

Molecular Mechanisms and Applications of Forensic Genetics

edited by Sara C Zapico

submission deadline 15 Oct 2026 | 2 articles | Viewed by 2976 | Submission Open

Keywords: forensic biology ; forensic genetic genealogy; next-generation sequencing (NGS); epigenetic markers/DNA methylation/non-coding RNAs; microbiome forensics; biomarker detection; DNA phenotyping; DNA degradation and preservation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Human Reproductive and Prenatal Genetics

edited by Edith Said

submission deadline 15 Oct 2026 | 1 articles | Viewed by 2453 | Submission Open

Keywords: reproductive genetics; female infertility; male infertility; recurrent pregnancy loss; preconception genetic testing; pre-implantation genetic testing; prenatal genetics; non-invasive prenatal testing; molecular genetics; cytogenetics; molecular cytogenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Aquatic Germplasm Resources and Genetic Breeding

edited by Wei Song

submission deadline 15 Oct 2026 | 2 articles | Viewed by 1655 | Submission Open

Keywords: fish; shrimp; shellfish; algae; geographical population; morphological difference; cytochrome oxidase subunit I (COI); microsatellites; genetic structure; genetic diversity; gene cloning; cellular localization; RNAi; gene overexpression

(This special issue belongs to the Section Animal Genetics and Genomics)

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