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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Chromatin and DNA Transcription, Replication, Repair and Recombination

edited by Adam Yongxin Ye

submission deadline 15 Nov 2026 | Viewed by 287 | Submission Open

Keywords: chromatin structure; 3D genome organization; loop extrusion; DNA transcription; DNA replication; DNA repair; DNA recombination

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Analysis of the Microbiome and Its Role in Animal Health

edited by Xiang Li

submission deadline 15 Nov 2026 | Viewed by 108 | Submission Open

Keywords: precision animal health; microbiome and metagenomics; zoonotic pathogens; food safety; precision intervention; comparative genomics; molecular genetics

(This special issue belongs to the Section Animal Genetics and Genomics)

NGS Applications in Hereditary Kidney Diseases: From Diagnostics to Clinical Impact

edited by Ighli Di Bari

submission deadline 15 Nov 2026 | Viewed by 104 | Submission Open

Keywords: ADPKD; NGS; nephrogenetics; WES; renal pharmacogenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Harnessing Multi-Omics Approaches to Unravel Plant–Microbe Interactions in Cultivated Plants: Implications for Climate Resilience and Sustainable Agriculture

edited by Samathmika Ravi,

Maria Cristina Della Lucia

and

Piergiorgio Stevanato

submission deadline 20 Nov 2026 | 1 articles | Viewed by 2759 | Submission Open

Keywords: multi-omics; plant–microbe interactions; climate resilience; agricultural sustainability; microbial dynamics

(This special issue belongs to the Section Plant Genetics and Genomics)

Integrative Cancer Genomics: Unveiling Novel Biomarkers

edited by

Victor Jin

and

Shengtong Han

submission deadline 20 Nov 2026 | 3 articles | Viewed by 1373 | Submission Open

Keywords: cancer; integrative genomics; cancer biomarker; multi-omics; cancer genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Genetics and Genomics of Plant Light Regulation

edited by

Bo Zhou

submission deadline 20 Nov 2026 | Viewed by 178 | Submission Open

Keywords: light signal transduction; plant development; molecular genetics; genomics; photoreceptor; flowering regulation; fruit ripening; anthocyanin synthesis; multi-omics; crop breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Advances in Plant Evolutionary Genomics

edited by

Hui Wang

submission deadline 20 Nov 2026 | Viewed by 164 | Submission Open

Keywords: plant evolution; comparative genomics; phylogenomics; adaptation; population genomics; genome evolution; natural selection; genetic diversity; phenotypic variation; molecular evolution; environmental adaptation

(This special issue belongs to the Section Plant Genetics and Genomics)

Perspectives on Craniofacial Genomics, Genetics, and Development

edited by Michael Cunningham

submission deadline 20 Nov 2026 | Viewed by 138 | Submission Open

Keywords: craniofacial; genetics; development; patterning; evolution; malformation; animal model; sense organs; cranial nerves; cervical spine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Dissection and Molecular Mechanisms of Plant Metabolic Pathways

edited by

Fei Zhou

submission deadline 20 Nov 2026 | Viewed by 107 | Submission Open

Keywords: plant metabolism; specialized metabolism; multi-omics integration; functional genomics; metabolic pathway; transcriptional regulation; plant biochemistry; metabolic engineering

(This special issue belongs to the Section Plant Genetics and Genomics)

Novel Strategies in Forensic Genetics

edited by

Marie Allen

submission deadline 25 Nov 2026 | 6 articles | Viewed by 4932 | Submission Open

Keywords: foresic DNA analysis; sample collection; DNA extraction; novel DNA markers; MPS; bioinformatics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genetic and Molecular Mechanisms of Insect Resistance

edited by Fen Li and Shuqian Tan

submission deadline 25 Nov 2026 | 1 articles | Viewed by 911 | Submission Open

Keywords: insect resistance; molecular mechanisms; genetic basis; detoxification enzymes; cytochrome P450; target-site resistance; metabolic resistance; gene amplification; gene expression regulation; genomics; transcriptomics; gene editing; adaptive evolution; insecticide resistance management (IRM); pest management

(This special issue belongs to the Section Animal Genetics and Genomics)

Functional Genomics and Genetics in Insects

edited by

Ji-Feng Shi

submission deadline 25 Nov 2026 | 1 articles | Viewed by 592 | Submission Open

Keywords: insect functional genomics; insect genetics; RNA interference; CRISPR/Cas9; transcriptomics; cuticle biology; chitin metabolism; gene regulation; pest insects; molecular mechanisms

(This special issue belongs to the Section Animal Genetics and Genomics)

Molecular Genetics and Genomic Medicine in Rare Disease

edited by Gu-Hwan Kim

submission deadline 25 Nov 2026 | Viewed by 383 | Submission Open

Keywords: rare genetic diseases; inherited disorders; genetic testing; next-generation sequencing; variant interpretation; genotype–phenotype correlation; functional genomics; molecular diagnosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Epigenetic Insights in Autoimmune Diseases

edited by

Cinzia Ciccacci

and Andrea Latini

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1669 | Submission Open

Keywords: autoimmune disorders; genetic factors; epigenetic factors; polymorphisms; gene–gene interactions; gene–miRNA interactions; miRNA; methylation state; genetic susceptibility

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Forensic DNA Profiling: PCR Techniques and Innovations

edited by

António Amorim

and

Laura Mendes Cainé

submission deadline 5 Dec 2026 | 4 articles | Viewed by 6642 | Submission Open

Keywords: forensic DNA profiling; PCR-based forensics; DNA analysis; next-generation sequencing; short tandem repeat (STR); Y-STR; single-nucleotide polymorphisms (SNPs); Y-SNP

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Epigenetics of Colorectal Cancer

edited by Kevin Tong

submission deadline 5 Dec 2026 | Viewed by 203 | Submission Open

Keywords: colorectal cancer; genetics; epigenetics; targeted treatment; genome-wide association studies

(This special issue belongs to the Section Epigenomics)

Genetic and Breeding Improvement of Horticultural Crops

edited by

Zhiqiang Wu

and

Xiaoni Zhang

submission deadline 10 Dec 2026 | 5 articles | Viewed by 4854 | Submission Open

Keywords: chloroplast genome; mitochondrial genome; nuclear genome; gene family evolution; functional genomics; genome editing; molecular breeding; horticultural crops

(This special issue belongs to the Section Plant Genetics and Genomics)

The Role of Non-Coding RNA in Cancer

edited by Amil M. Shah

submission deadline 10 Dec 2026 | 3 articles | Viewed by 3161 | Submission Open

Keywords: non-coding RNA (ncRNA); ncRNA classification; ncRNA biogenesis; ncRNA functions; diagnostic and prognostic biomarkers; targeted therapy; nucleic acid-based therapy; cell regulatory networks; cancer attractor states; computational network models; omics technology (single-cell RNA-seq, spatial transcriptomics, and single-cell multi-omics)

(This special issue belongs to the Section RNA)

Genetics and Genomics in Physical Activity, Sports and Injury

edited by

Jon Brazier

, Mark Antrobus and

Alun Williams

submission deadline 10 Dec 2026 | Viewed by 363 | Submission Open

Keywords: sport genetics; musculoskeletal injury; athletic performance; physical activity; exercise; genomics; epigenetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Beyond Genomics: Leveraging Epigenomics for the Genetic Improvement of Crops

edited by Qiutao Xu and

Xuan Ma

submission deadline 10 Dec 2026 | Viewed by 105 | Submission Open

Keywords: epigenomics; DNA methylation; histone modifications; crop improvement; yield; abiotic stress resilience; transcriptional regulation; molecular breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Dissection of Plant Responses to Biotic and Abiotic Stresses: From Gene Discovery to Functional Mechanisms

edited by Wangsheng Zhu

submission deadline 15 Dec 2026 | 2 articles | Viewed by 1037 | Submission Open

Keywords: GWAS; genetic variation; gene identification; stress-responsive genes; plant–pathogen interaction

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics of Head and Neck Disorders

edited by Christos Yapijakis

submission deadline 15 Dec 2026 | Viewed by 266 | Submission Open

Keywords: head and neck pathology; craniofacial genetics; orofacial genetics; developmental genetics; neurogenetics; cancer genetics; genomics and gene variation; epigenetics; personalized medicine and dentistry; genetic counseling and ethics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Breeding in Forest Trees

edited by Liwen Wu

submission deadline 15 Dec 2026 | 1 articles | Viewed by 249 | Submission Open

Keywords: germplasm utilization; tree genetics; tree breeding; genomics; molecular breeding; genomic selection; gene editing; trait improvement; genetic function and genetic network

(This special issue belongs to the Section Plant Genetics and Genomics)

Rare Genetic Disorders: Molecular Diagnosis, Pathogenesis Insights and Precision Medicine Treatment

edited by

Francesca Clementina Radio

submission deadline 15 Dec 2026 | Viewed by 111 | Submission Open

Keywords: genetic disorders; rare disease; neurodevelopmental disorder; genotype-phenotype correlations; precision medicine; genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Molecular Mechanisms of Rare Monogenic Disorders

edited by

Massimiliano Chetta

submission deadline 15 Dec 2026 | Viewed by 95 | Submission Open

Keywords: rare monogenic disorders; functional genomics; genotype–phenotype correlation; next-generation sequencing; multi-omics integration; epigenetic regulation; RNA splicing defects; gene therapy; precision medicine; molecular pathogenesis

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Ophthalmic Genetics

edited by

Se Joon Woo

submission deadline 20 Dec 2026 | Viewed by 221 | Submission Open

Keywords: inherited eye diseases; inherited retinal diseases; retinitis pigmentosa; macular dystrophy; cone dystrophy; genotype; gene therapy; clinical trial; imaging; genetic mechanism; genome editing; phenotype

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Genomics in Aquaculture and Fisheries

edited by

Hongyan Wang

submission deadline 20 Dec 2026 | Viewed by 163 | Submission Open

Keywords: genetics and genomics; aquaculture; disease resistance; genomic selection/breeding; functional genomics/multi-omics; sustainable aquatic food production

(This special issue belongs to the Section Animal Genetics and Genomics)

Feature Papers in Toxicogenomics

edited by

Gary Hardiman

submission deadline 20 Dec 2026 | Viewed by 162 | Submission Open

Keywords: single-cell, spatial, and multi-omics toxicogenomics; adverse outcome pathways (AOPs) and mechanism-based toxicity frameworks; translational toxicogenomics and regulatory science applications

(This special issue belongs to the Section Toxicogenomics)

Feature Papers in "Neurogenetics and Neurogenomics": 2026

edited by

Claudia Ricci

and Micheal Palladino

submission deadline 25 Dec 2026 | 8 articles | Viewed by 6531 | Submission Open

Keywords: genomics; neurological diseases; multi-omics studies; brain development and function; precision medicine; pathogenic mechanisms

(This special issue belongs to the Section Neurogenomics)

Feature Papers: Molecular Genetics and Genomics 2026

edited by

Albert Jeltsch

and

Paolo Cinelli

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1534 | Submission Open

Keywords: single-cell and spatial omics; genome-targeted RNA therapeutics and diagnostics; next-generation CRISPR genome and epigenome editing; chromatin remodeling and dynamics; epigenetics, DNA methylation, histone modification, histone code; DNA replication, repair, recombination, mobile DNA, mitochondrial DNA; RNA biology and molecular regulation; molecular mechanisms of cell signaling, signal transduction, cell cycle, cell death, and stem cell regulation; post-transcriptional regulation of gene expression; developmental genetics; AI-powered genomics and genetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gene Family Evolution and Functional Genomics in Medicinal, Aromatic, and Tropical Plants

edited by

Xiao-Lu Chen

and

Ying Liu

submission deadline 25 Dec 2026 | Viewed by 103 | Submission Open

Keywords: gene family evolution; gene family analysis; functional genomics; genome-wide identification; comparative genomics; medicinal plants; aromatic plants; tropical and subtropical plants; transcriptomics; metabolomics; specialized metabolite biosynthesis; terpenoid biosynthesis; stress response; environmental adaptation; developmental regulation

(This special issue belongs to the Section Plant Genetics and Genomics)

Feature Papers in the Population and Evolutionary Genetics and Genomics Field 2026

edited by

Zissis Mamuris

and

Maria-Anna Kyrgiafini

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2581 | Submission Open

Keywords: population genetics; evolutionary genomics; genetic diversity; adaptation; natural selection

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Feature Papers in Microbial Genetics and Genomics 2026

edited by

Jose María Requena

submission deadline 31 Dec 2026 | 1 articles | Viewed by 866 | Submission Open

Keywords: virus; bacteria; protists; parasites; genomics; transcriptomics; genetics; drug resistance; molecular evolution; data re-analysis

(This special issue belongs to the Section Microbial Genetics and Genomics)

Feature Papers in Human Genomics and Genetic Diseases 2026

edited by

Mariarosa Anna Beatrice Melone

and

Gil Atzmon

submission deadline 31 Dec 2026 | Viewed by 339 | Submission Open

Keywords: genetics of monogenic diseases and complex diseases, genotype–phenotype relationships; population genomics and genetic epidemiology; precision medicine, pharmacogenetics and pharmacogenomics; targeted genome editing, gene therapy and delivery systems, genetically engineered cell therapy; RNA- and small nucleic acid-based therapeutics; genetic testing and molecular diagnostics, biomarker development and application, genome-wide association studies; epigenetic therapy; developmental genetics, epigenetics, and epigenomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Feature Papers in the RNA Field

edited by

Isabelle Behm-Ansmant

and

Christiane Branlant

submission deadline 31 Dec 2026 | Viewed by 331 | Submission Open

Keywords: tRNAs; rRNAs; mRNAs; miRNAs; lncRNAs; sRNAs; siRNAs; RNA epigenetics; RNA modifications; RNA secondary and tertiary structure; viral RNAs; RNA binding proteins; RNA transcription; RNA translation

(This special issue belongs to the Section RNA)

Virus Ecology, Diversity and Evolution Through the Lens of Genomics

edited by

Ken Stedman

and Ignacio de la Higuera

submission deadline 31 Dec 2026 | Viewed by 264 | Submission Open

Keywords: virus ecology; viral diversity; virus evolution; viromics; eco-genomics; metagenomics

(This special issue belongs to the Section Viral Genomics)

Feature Papers in the ‘Animal Genetics and Genomics’ Section—2026

edited by

Antonio Figueras

and

Pedro Lorite Martínez

submission deadline 31 Dec 2026 | Viewed by 174 | Submission Open

Keywords: applied genetics and genomics in species of economic importance; companion animal genetics and genomics; breeding and genetic selection; genetics and genomics of aquaculture species; genetics of immune response and disease resistance; genome-edited animals and animal epigenetics; animal population genetics, polymorphisms and genome annotation; genetics applied to the interaction of the microbiome and genetic traits of interest; bioinformatics analysis in animal genetics; genomics and evolution; cytogenomics

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Regulation and Molecular Basis of Plant Abiotic Stress Tolerance

edited by

Zhiming Yu

and

Yifeng Wang

submission deadline 31 Dec 2026 | Viewed by 147 | Submission Open

Keywords: abiotic stress; receptors; calcium channels; secondary messengers; reactive oxygen species; phytohormone metabolism; transcription factors; epigenetic mechanism; RNA signaling; hormone-signaling pathways; functional genomics; genome-wide association studies; precise genome-editing tools; integrated multi-omics; systems biology

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic and Genomic Insights into the Pathogenesis of Kidney Disease

edited by Grazia Maria Virzi

submission deadline 10 Jan 2027 | Viewed by 233 | Submission Open

Keywords: kidney disease; genomics; genetics; molecular pathogenesis; precision medicine; rare nephropathies; common nephropathies; omics technologies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Single-Cell and Spatial Multi-Omics in Human Diseases

edited by

Xin Wang

submission deadline 15 Jan 2027 | 6 articles | Viewed by 12538 | Submission Open

Keywords: single-cell omics; spatial multi-omics; pathogenesis of disease; biomarkers; computational tools; integrative biology

(This special issue belongs to the Section Bioinformatics)

Genetic Insights and Molecular Pathways in Alzheimer's Disease: Unveiling the Complexity of Neurodegeneration

edited by

Marta Rusek

and

Alessandro Romano

submission deadline 15 Jan 2027 | 2 articles | Viewed by 1776 | Submission Open

Keywords: Alzheimer’s disease; neurodegeneration; amyloid-β pathology; tau pathology; APOE ε4; APP; PSEN1; PSEN2; GWAS; neuroinflammation; mitochondrial dysfunction; oxidative stress; proteostasis; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Mitochondrial Genetics in Health and Disease

edited by Jing Wang

submission deadline 15 Jan 2027 | 1 articles | Viewed by 639 | Submission Open

Keywords: primary mitochondrial disorders; mitochondrial DNA; mitochondrial dysfunction; diagnosis; therapeutic approaches

(This special issue belongs to the Section Molecular Genetics and Genomics)

Plant Genetics, Evolution, Cytogenetics and Cytogenomics for Biodiversity Conservation

edited by

Eric Javier Martínez

Ana Isabel Honfi

and

Anna Reutemann

submission deadline 20 Jan 2027 | 3 articles | Viewed by 4583 | Submission Open

Keywords: plant conservation; cytogenetics; cytogenomics; plant evolution; population genetics; genome evolution; chromosomal variation; polyploidy; biodiversity; genomic resources

(This special issue belongs to the Section Plant Genetics and Genomics)

Targeting RNA Coding Mechanisms in Disease Molecular Pathways

edited by

Wangyong Yang

submission deadline 20 Jan 2027 | 1 articles | Viewed by 643 | Submission Open

Keywords: RNA therapeutics; RNA modifications (epitranscriptomics); non-coding RNA (ncRNA); alternative splicing; RNA-binding proteins (RBPs); RNA-targeted small molecules; gene therapy; molecular pathways; disease biomarkers; RNA vaccines

(This special issue belongs to the Section RNA)

Application of Molecular or Genetic Markers in Liquid Biopsy for Urogenital Cancers

edited by

Guorong Li

submission deadline 25 Jan 2027 | 1 articles | Viewed by 3004 | Submission Open

Keywords: liquid biopsy; extracellular vesicle; exosome; biotechnology; precision medicine/personalized medicine; diagnosis/screening; urogenital cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Epidemiology of Multifactorial Diseases

edited by

Maria Tziastoudi

and Ioannis Stefanidis

submission deadline 25 Jan 2027 | 2 articles | Viewed by 2689 | Submission Open

Keywords: genetic association studies; polygenic risk scores; functional genomics; causal inference; mendelian randomization; translational applications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Mechanisms and Therapeutic Strategies in Ovarian Cancer

edited by Aimee Stablewski

submission deadline 25 Jan 2027 | Viewed by 389 | Submission Open

Keywords: epithelial ovarian cancer (EOC); genetic alterations; epigenetic regulation; tumor microenvironment; therapeutic strategies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Basis and Molecular Mechanism of Plant Immunity

edited by

Aijun Wang

and Desuo Yin

submission deadline 25 Jan 2027 | Viewed by 373 | Submission Open

Keywords: plant; phytopathogens; immune responses; molecular mechanisms; regulatory pathways; interactions mechanisms

(This special issue belongs to the Section Plant Genetics and Genomics)

Epigenetic Drivers of Cancer: Enhancing Diagnosis, Prevention, and Treatment

edited by

Robert Philibert

and Steven R. H. Beach

submission deadline 25 Jan 2027 | Viewed by 37 | Submission Open

Keywords: precision medicine; quantitative methylation; prevention; cancer; screening; health behavior; side-effects; recurrence; health disparities; mortality; morbidity; clinical utility/acceptability

(This special issue belongs to the Section Epigenomics)

Molecular Biomarkers in Cancer Diagnosis, Prognosis and Therapy

edited by

Antonis Giakountis

submission deadline 25 Jan 2027 | Viewed by 24 | Submission Open

Keywords: molecular biomarkers; cancer diagnosis and prognosis; precision oncology; next-generation sequencing (NGS); liquid biopsy; circulating tumor cells (CTCs)

(This special issue belongs to the Section Genetic Diagnosis)

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