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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Epigenetics and Multiple Sclerosis

edited by Lara Kular and

Sudheer Kumar Gara

submission deadline 20 Dec 2025 | Viewed by 133 | Submission Open

Keywords: epigenetics; multiple sclerosis; DNA methylation; histone posttranslational modifications; non-coding RNAs

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Genetics of Skeletal Development

edited by André M Travessa,

Zhousheng Xiao

and

Dragan Primorac

submission deadline 20 Dec 2025 | Viewed by 106 | Submission Open

Keywords: skeletal development; skeletal dysplasias; clinical genetics; human genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genotype/Phenotype Relationship Versus Therapy Optimization in a Monocentric Fabry Disease Cohort

edited by Marisa Santostefano

submission deadline 20 Dec 2025 | Viewed by 101 | Submission Open

Keywords: genotype; phenotype; genomic analysis; enzymatic therapy; gene therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Diagnosis and Treatment of Duchenne Muscular Dystrophy

edited by Liubov V. Gushchina

submission deadline 20 Dec 2025 | Viewed by 77 | Submission Open

Keywords: Duchenne muscular dystrophy; viral vectors; non-viral therapy; gene editing; common and rare mutations; biomarkers; methods of diagnosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Pediatric Neurology and Genetics

edited by

Roberta Milone

, Agatino Battaglia and Alberto Danieli

submission deadline 20 Dec 2025 | Viewed by 66 | Submission Open

Keywords: rare neurological diseases; genomics; next-generation sequencing; cytogenetics; child neurology

(This special issue belongs to the Section Neurogenomics)

Clinical Genetics of Diabetes

edited by Tuncay Delibasi

submission deadline 20 Dec 2025 | Viewed by 60 | Submission Open

Keywords: precision diabetology; genomics; β -cell dysfunction; insulin resistance; pharmacogenomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Functional Genomics Insights into the Genetic Improvement of Stress Resistance in Economic Crops

edited by

Mingku Zhu

and Xiaoqing Meng

submission deadline 20 Dec 2025 | Viewed by 45 | Submission Open

Keywords: economic crops; functional genomics; molecular biology; genetic improvement; agricultural biotechnology

(This special issue belongs to the Section Plant Genetics and Genomics)

Novel Biomarkers of Neurodegenerative Diseases

edited by Arash Salardini

submission deadline 20 Dec 2025 | Viewed by 31 | Submission Open

Keywords: neurodegenerative diseases; biomarker discovery; Alzheimer's disease; Parkinson's disease; precision medicine; machine learning

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Decoding the Epigenetic Language: Combinatorial Chromatin Modifications in Gene Regulation

edited by Kaur Gundeep and John R. Horton

submission deadline 20 Dec 2025 | Viewed by 21 | Submission Open

Keywords: epigenetics; gene regulation; chromatin modifications; chromatin architecture; computational epigenomics; CRISPR epigenome editing; epigenetic therapies

(This special issue belongs to the Section Epigenomics)

Genetics and Genomics of Pediatric Neurological Disorders

edited by Andrea L. Gropman

submission deadline 20 Dec 2025 | Viewed by 10 | Submission Open

Keywords: genomics; pediatric neurology; precision medicine; neurodevelopmental disorders; translational research

(This special issue belongs to the Section Neurogenomics)

Genomic Diversity and Biological Evolution Studies of Marine Bacteria

edited by

Pengxia Wang

submission deadline 20 Dec 2025 | Viewed by 9 | Submission Open

Keywords: gene; genetics; genomics; molecular biology; horizontal gene transfer; adaptation; evolution; metagenomic analysis

(This special issue belongs to the Section Microbial Genetics and Genomics)

Molecular Mechanisms Responsible for Radiation-Induced Toxicity of Normal Tissue

edited by

Rupak Pathak

submission deadline 25 Dec 2025 | 7 articles | Viewed by 24089 | Submission Open

Keywords: radioresponsive genes; inflammation; genetic markers of radiation damage; immunotherapy; radioprotectors; DNA damage and repair

(This special issue belongs to the Section Toxicogenomics)

Single-Cell and Spatial Multi-Omics in Human Diseases

edited by

Xin Wang

submission deadline 25 Dec 2025 | 2 articles | Viewed by 1051 | Submission Open

Keywords: single-cell omics; spatial multi-omics; pathogenesis of disease; biomarkers; computational tools; integrative biology

(This special issue belongs to the Section Bioinformatics)

Current Advances in Inherited Retinal Disease

edited by

Se Joon Woo

submission deadline 25 Dec 2025 | 1 articles | Viewed by 325 | Submission Open

Keywords: inherited retinal diseases; retinitis pigmentosa; macular dystrophy; cone dystrophy; genotype; gene therapy; clinical trial; imaging; genetic mechanism; genome editing; phenotype

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Hereditary Traits and Diseases in Companion Animals

edited by

Lucie Chevallier

and

Marie Abitbol

submission deadline 25 Dec 2025 | Viewed by 85 | Submission Open

Keywords: genetic traits; hereditary diseases; companion animals; spontaneous disease models; veterinary genetics; genetic selection; breed-specific diseases

(This special issue belongs to the Section Animal Genetics and Genomics)

Research on Genetics and Breeding of Rice

edited by Xiaojin Luo

submission deadline 25 Dec 2025 | Viewed by 73 | Submission Open

Keywords: rice breeding; molecular genetics; rice germplasm; QTL identification and gene cloning; genetic function and genetic network; breeding technologies

(This special issue belongs to the Section Plant Genetics and Genomics)

The Function and Molecular Mechanism for Immune Responses in Human Diseases

edited by Zsofia Banlaki

submission deadline 25 Dec 2025 | Viewed by 67 | Submission Open

Keywords: leukocyte; cytokine; immune receptor; signal transduction; gene expression; antibody-antigen; major histocompatibility complex; complement system; inflammation

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Forage and Grass Genetics and Genomics

edited by Peizhi Yang, Jinghui Gao,

Yuman Cao

and Tieyuan Liu

submission deadline 25 Dec 2025 | Viewed by 47 | Submission Open

Keywords: molecular genetics; proteomics; polyploid genomes; genotype– phenotype association analysis; forage gene editing; biotic or abiotic stress; inter-biological interactions

(This special issue belongs to the Section Plant Genetics and Genomics)

Genomic, Transcriptome Analysis in Animals

edited by

Min Yang

and Mengxun Li

submission deadline 25 Dec 2025 | Viewed by 41 | Submission Open

Keywords: multi-omics methodologies; genetic and epigenetic regulation; mechanisms of the elucidation of domesticated animal physiological characteristics and economic traits

(This special issue belongs to the Section Animal Genetics and Genomics)

The 15th Anniversary of Genes: Feature Papers in the Human Genomics and Genetic Diseases Section

edited by

Gil Atzmon

and

Mariarosa Anna Beatrice Melone

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1010 | Submission Open

Keywords: genetics of monogenic diseases and complex diseases; genotype– phenotype relationships; population genomics and genetic epidemiology; precision medicine; pharmacogenetics and pharmacogenomics; targeted genome editing; gene therapy and delivery systems; genetically engineered cell therapy; RNA- and small nucleic acid-based therapeutics; genetic testing and molecular diagnostics; biomarker development and application; genome-wide association studies; epigenetic therapy; developmental genetics; epigenetics; and epigenomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genome Assembly and Annotation in Biology

edited by

Yasukazu Nakamura

Hidemasa Bono

and Mika Sakamoto

submission deadline 31 Dec 2025 | Viewed by 810 | Submission Open

Keywords: genome assembly; genome annotation; structural gene prediction; functional gene prediction; reference genomes; annotation tools and pipelines; comparative genomics

(This special issue belongs to the Section Bioinformatics)

15th Anniversary of Genes: Feature Papers in the “Plant Genetics and Genomics” Section

edited by

Jacqueline Batley

and

Roberto Tuberosa

submission deadline 31 Dec 2025 | 2 articles | Viewed by 734 | Submission Open

Keywords: epigenetic editing; genetics; genomics; pangenome; plants; QTL mapping; QTL cloning; regulation of gene expression; transcriptome

(This special issue belongs to the Section Plant Genetics and Genomics)

The 15th Anniversary of Genes: Feature Papers in the "Animal Genetics and Genomics" Section

edited by

Antonio Figueras

and

Pedro Lorite Martínez

submission deadline 31 Dec 2025 | Viewed by 195 | Submission Open

Keywords: applied genetics and genomics in species of economic importance; companion animal genetics and genomics; breeding and genetic selection; genetics and genomics of aquaculture species; genetics of immune response and disease resistance; genome-edited animals and animal epigenetics; animal population genetics; polymorphisms and genome annotation; genetics applied to the interaction of microbiome and genetic traits of interest; bioinformatics analysis in animal genetics; genomics and evolution; cytogenomics

(This special issue belongs to the Section Animal Genetics and Genomics)

The Development of Genetic Assessment for Neurotoxicity

edited by

and

submission deadline 31 Dec 2025 | Viewed by 102 | Submission Open

Keywords: neurotoxicity; genetics; neurodegenerative disorders; mental disorders

(This special issue belongs to the Section Toxicogenomics)

Genomic Data Analysis in Human Health and Disease

edited by Ighli Di Bari and

Zhaohui S. Qin

submission deadline 31 Dec 2025 | Viewed by 101 | Submission Open

Keywords: protein modeling and structure-function prediction; variant pathogenicity prediction tools; functional annotation of genetic variants; machine learning in genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The 15th Anniversary of Genes: Feature Papers in the Population and Evolutionary Genetics and Genomics Section

edited by

Zissis Mamuris

and

Maria-Anna Kyrgiafini

submission deadline 31 Dec 2025 | Viewed by 80 | Submission Open

Keywords: population genetics; evolutionary genomics; genetic diversity; adaptation; natural selection

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Research Updates in Forensic Genetics

edited by Massimo Lancia

submission deadline 31 Dec 2025 | Viewed by 67 | Submission Open

Keywords: next generation sequencing; single cell analysis; time since deposition; time since death; DNA phenotyping; biogeographic ancestry; age prediction; familial search; disaster victim identification; trace DNA contextualisation

(This special issue belongs to the Section Molecular Genetics and Genomics)

15th Anniversary of Genes: Feature Papers in the “Cytogenomics” Section

edited by

Monica Bullejos

submission deadline 31 Dec 2025 | Viewed by 64 | Submission Open

Keywords: molecular cytogenetics; cytogenomics; microarray; chromosome biology; karyotyping; high-throughput cytogenetics; genome organization; comparative genomics; karyomapping; optical mapping

(This special issue belongs to the Section Cytogenomics)

The 15th Anniversary of Genes: Feature Papers in the RNA Section

edited by

Christiane Branlant

submission deadline 31 Dec 2025 | Viewed by 59 | Submission Open

Keywords: tRNAs; rRNAs; mRNAs; miRNAs; lncRNAs; sRNAs; siRNAs; RNA epigenetics; RNA modifications; RNA secondary and tertiary structure; viral RNAs; RNA binding proteins; RNA transcription; RNA translation

(This special issue belongs to the Section RNA)

Insights into RNA Coding and Transcriptional Regulation

edited by Zihua Hu

submission deadline 5 Jan 2026 | Viewed by 10 | Submission Open

Keywords: RNA coding; transcriptomics; non-coding RNAs (ncRNA); long non-coding RNA (lncRNA); microRNA (miRNA); RNA modifications; RNA splicing; RNA editing; RNA in transcriptional and post-transcriptional regulation; gene expression regulation; scRNA

(This special issue belongs to the Section RNA)

Structural and Evolutionary Perspectives on Immunogenetic Variation in Autoimmune and Related Disorders

edited by Athena Andreou and Catriona Kelly

submission deadline 10 Jan 2026 | Viewed by 87 | Submission Open

Keywords: gene polymorphisms; exonic and intronic variants; structural biology; biophysical analysis; structural evolution; protein molecular function and evolution; immunological biomarkers; human genetic diseases; evolutionary genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Epigenetic Mechanisms of Stem Cell Aging

edited by Romeo Blanc

submission deadline 10 Jan 2026 | Viewed by 81 | Submission Open

Keywords: stem cell aging; epigenetics; DNA methylation; histone modifications; chromatin remodeling; single-cell omics; transcriptomics; regenerative decline; cell fate decisions; tissue homeostasis

(This special issue belongs to the Section Epigenomics)

Advances in Genetic Variants in Neurological and Psychiatric Diseases

edited by

Evelina Mocci

submission deadline 10 Jan 2026 | Viewed by 15 | Submission Open

Keywords: pleiotropy; comorbidity; meta-analysis; polygenic risk score; transcriptome; network analysis; psychiatric; neurology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Germplasm Resource Evaluation and Genetic Breeding of Sheep and Goats

edited by Huihua Wang

submission deadline 10 Jan 2026 | Viewed by 7 | Submission Open

Keywords: sheep; goat; conservation germplasm resources; genetic breeding; genomic selection; reproductive biotechnology; functional genomics

(This special issue belongs to the Section Animal Genetics and Genomics)

Advances in Veterinary Genetics and Genomics

edited by

Petra Zenke

and

Enikő Fehér

submission deadline 15 Jan 2026 | Viewed by 141 | Submission Open

Keywords: veterinary genetics; animal genomics; infectious diseases and disease resistance; pathogenetics; genomic selection and livestock improvement; conservation genetics; epigenetics; CRISPR gene editing; next-generation sequencing (NGS); forensic genetics; LAMP method

(This special issue belongs to the Section Animal Genetics and Genomics)

Next-Generation Diagnosis and Treatment of Hematologic Diseases

edited by

Thomas David Daniel Kazmirchuk

and

Ashkan Golshani

submission deadline 15 Jan 2026 | Viewed by 121 | Submission Open

Keywords: hematologic disease; hematology; thrombosis and hemostasis; bleeding disorders; artificial intelligence; next-generation theranostics; therapeutics; diagnostics; peptide design; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Integrating Traditional and Modern Technology for Cattle Genetic Improvement

edited by

Xibi Fang

and

Tianyu Deng

submission deadline 15 Jan 2026 | Viewed by 114 | Submission Open

Keywords: cattle breeding; animal genetics; genomic selection; functional genomics; epigenetics and epigenomics; functional genes; Quantitative Trait Loci (QTL)

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic and Epigenetic Mechanisms Underlying Cancer Stem Cells and Their Implications for Novel Therapeutic Approaches

edited by

Fumihiko Kakizaki

and

Frank Buchholz

submission deadline 15 Jan 2026 | Viewed by 101 | Submission Open

Keywords: cancer stem cell; metastasis; cancer-associated gene; model organism for cancer research; therapeutics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Animal Virus Immunology and Genomics

edited by

Huijun Lu

and

Changzhan Xie

submission deadline 15 Jan 2026 | Viewed by 89 | Submission Open

Keywords: epidemiology; gene editing; genome; transcriptome; and proteome; synthetic biology; high-throughput sequencing; multi-omics; transcription factor; immunology

(This special issue belongs to the Section Animal Genetics and Genomics)

Immunotherapy in Glioblastoma: Genetic Insights and Innovations

edited by

Richard J. Tancredi

submission deadline 15 Jan 2026 | Viewed by 17 | Submission Open

Keywords: glioblastoma; treatment strategy; genetic mutations; immunotherapies; checkpoint inhibitors

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Systems Biology of Single Cells: Bridging Genomics and Functional Insights

edited by

Guilherme Targino Valente

submission deadline 15 Jan 2026 | Submission Open

Keywords: systems biology; graph theory; single-cell RNA-Seq; spatial transcriptomics; molecular networks; complex networks

(This special issue belongs to the Section Bioinformatics)

Function and Regulatory Mechanism of MicroRNAs in Cancers

edited by

Alicja Petniak

Paulina Gil-Kulik

and

Janusz Kocki

submission deadline 15 Jan 2026 | Submission Open

Keywords: microRNAs (miRNAs); cancer biomarkers; gene regulation; miRNA-based therapies; tumor microenvironment; cancer progression; drug resistance; non-coding RNAs; epigenetic regulation; cancer immunology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Genetic Mechanisms of Floral Development

edited by Kaifeng Ma

submission deadline 16 Jan 2026 | Submission Open

Keywords: floral induction and differentiation; flower bud formation and dormancy; floral organ; flower pattern; flower color and fragrance; blooming period; molecular and genetic mechanism

(This special issue belongs to the Section Plant Genetics and Genomics)

Cytogenetics/Cytogenomics and Functional Genomics in Human Health and Disease

edited by

Patrick R. Gonzales

submission deadline 20 Jan 2026 | Viewed by 77 | Submission Open

Keywords: functional genomics; cytogenetics; cytogenomics; microarray; optical genome mapping (OGM); Hi-C; genomic proximity mapping (GPM); intergenic; topologically associating domains (TAD); expression

(This special issue belongs to the Section Cytogenomics)

New Insight into the Genetic and Molecular Aspects of Yeast Nutrient Metabolism

edited by Roman Maslanka and

Renata Zadrag-Tecza

submission deadline 20 Jan 2026 | Submission Open

Keywords: yeasts as a model organism; yeast metabolism; nutrient sensing; sugar/hexose transport; central carbon metabolism; catabolite repression; nutrient availability; resource allocation; calorie restriction; cAMP-PKA signaling; metabolic flux; metabolic adaptation; genetic and transcriptional regulation; cellular homeostasis; molecular biology of yeast

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genomics and Proteomics-Based Molecular Diagnostics and Targeted Therapies in Cancer

edited by

Hilal Arnouk

submission deadline 25 Jan 2026 | Viewed by 62 | Submission Open

Keywords: molecular diagnostics; targeted therapies; biomarkers; precision medicine oncology; chemotherapy; small-molecule drugs; monoclonal antibodies; cancer immunotherapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Environmental Factors in Psychiatric Disorders

edited by

Sarah Tosato

submission deadline 25 Jan 2026 | Viewed by 32 | Submission Open

Keywords: PGS; environmental factors; epigenetics; prenatal environmental exposures; GWAS; GxE interactions

(This special issue belongs to the Section Genes & Environments)

Novel Insights into Forensic Genetics

edited by

Simone Grassi

Sarah Gino

and

Paola A. Magni

submission deadline 31 Jan 2026 | Viewed by 125 | Submission Open

Keywords: forenscic genetics; molecular autopsy; forensic omics; post-mortem genetic testing; legal medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics and Genomics of Pancreatitis

edited by

Jian-Min Chen

submission deadline 10 Feb 2026 | Viewed by 118 | Submission Open

Keywords: recurrent acute pancreatitis; chronic pancreatitis; gene– environment interaction; genetics; genomics; pharmacogenomics; personalized medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Identifying Fertility Biomarkers Using Omics Approach

edited by

Muhammet Rasit Ugur

submission deadline 10 Feb 2026 | Viewed by 14 | Submission Open

Keywords: fertility; infertility; biomarker; omics; multi-omics; genomics; transcriptomics; proteomics; metabolomics; epigenomics; lipidomic; microbiomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

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