Feature Papers in Microbial Genetics and Genomics 2026

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 779

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Guest Editor
Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Universidad Autonoma de Madrid, 28049 Madrid, Spain
Interests: Leishmania; Trypanosoma; heat shock proteins; RNA binding proteins; regulation of gene expression; genomics; transcriptomics
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Dear Colleagues,

Microbiology encompasses several interlinked sub-disciplines, including virology, bacteriology, protistology, mycology and parasitology. This Special Issue aims to collect outstanding advances in the molecular aspects of microorganisms. There is no restriction regarding whether the organism is a pathogen or not, but the published studies should contribute significant advances in our knowledge regarding the molecular biology of microorganisms. 

High-throughput omics techniques (genomics, transcriptomics, proteomics, metabolomics, epigenomics, etc.) are providing a huge amount of data. In this regard, this Special Issue also welcomes data articles in which datasets are reported with the sole condition that data have to be deposited in dedicated repositories and that the samples and methods are described in a detailed manner. 

Thus, this Special Issue plans to provide an overview of the most recent advances in the field of Molecular Microbiology. These topics include but are not limited to microbial genomics, environmental microbiology, host–microbe interaction, microbial pathogens, omics-based datasets, molecular taxonomy and any other topics in which the molecular biology of microorganisms is the guiding thread. Review articles are also welcome.

Dr. Jose María Requena
Guest Editor

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Keywords

  • virus
  • bacteria
  • protists
  • parasites
  • genomics
  • transcriptomics
  • genetics
  • drug resistance
  • molecular evolution
  • data re-analysis

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Published Papers (1 paper)

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Research

16 pages, 1814 KB  
Article
Transfer RNA (tRNA) Genes, Codon Usage and Translational Efficiency in Leishmania infantum
by Ariel Nájera-Peso, Andrés Carrazco-Montalvo, Javier Adán-Jiménez and Jose M. Requena
Genes 2026, 17(6), 620; https://doi.org/10.3390/genes17060620 - 29 May 2026
Viewed by 305
Abstract
Background/Objectives: Protozoan parasites of the genus Leishmania are causative agents of a group of devastating human diseases, known as leishmaniasis. These microorganisms possess very unusual mechanisms of gene expression that are poorly understood. This study was aimed at analyzing the tRNA repertoire [...] Read more.
Background/Objectives: Protozoan parasites of the genus Leishmania are causative agents of a group of devastating human diseases, known as leishmaniasis. These microorganisms possess very unusual mechanisms of gene expression that are poorly understood. This study was aimed at analyzing the tRNA repertoire encoded in the Leishmania infantum genome, a species responsible for the most severe form of disease, visceral leishmaniasis. tRNAs are adaptor molecules aimed at decoding mRNAs into proteins. Results: A total of 92 tRNA genes, dispersed on 38 loci, were identified, often located in regions where unidirectional gene arrays converge. Putative intronic sequences were inferred for three tRNA genes, and, remarkably, nine tRNAs were found to overlap with the protein-coding sequences of annotated genes. According to structural predictions, the L. infantum tRNA repertoire covers 49 out of the 61 possible anticodons, but because of the well-documented wobble phenomenon, these are enough to decode all codons in the 8532 protein-coding genes currently annotated in its genome. As illustrated in this study, codon usage is a well-conserved trait among different Leishmania species but it differs substantially regarding its human host. Finally, we analyzed tRNA adaptation index (tAI) parameters, codon usage metrics, and relative protein expression levels. Conclusions: Apart from providing the tRNA gene repertoire and its genome distribution, we have shown the existence of a statistically significant, positive correlation between the tAI scores and protein expression levels in L. infantum promastigotes. Full article
(This article belongs to the Special Issue Feature Papers in Microbial Genetics and Genomics 2026)
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