Chromatin and DNA Transcription, Replication, Repair and Recombination
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 15 May 2026 | Viewed by 3
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chromatin serves as the central platform orchestrating the essential processes of DNA transcription, replication, repair and recombination. Recent advances in chromosome conformation capture and high-resolution imaging have revealed that chromatin structure and 3D genome organization are highly dynamic and tightly regulated across cellular contexts. Loop extrusion, mediated by cohesin and other proteins, underlies genome partitioning and brings regulatory DNA elements into contact with trans-acting protein factors to coordinate gene expression and DNA maintenance. Understanding how these multilayered chromatin architectures modulate DNA-associated processes is fundamental to elucidating the mechanisms that safeguard genomic integrity and to revealing how their dysregulation contributes to diseases.
This Special Issue aims to bring together original research articles and reviews that explore the interplay among chromatin structure, 3D genome organization, loop extrusion and DNA transcription, replication, repair and recombination, spanning from mechanistic investigations to evolutionary perspectives. Contributions addressing genome instability, chromatin- and loop-extrusion–associated diseases as well as emerging technologies for probing chromatin dynamics, are particularly welcome.
Dr. Yongxin Adam Ye
Guest Editor
Manuscript Submission Information
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Keywords
- chromatin structure
- 3D genome organization
- loop extrusion
- DNA transcription
- DNA replication
- DNA repair
- DNA recombination
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