Special Issues

Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Genotype/Phenotype Relationship and Therapy Optimization in a Monocentric Fabry Disease Cohort
edited by Marisa Santostefano
submission deadline 20 Dec 2025 | Viewed by 192 | Submission Open
Keywords: genotype; phenotype; genomic analysis; enzymatic therapy; gene therapy
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Clinical Genetics of Diabetes
edited by Tuncay Delibasi
submission deadline 20 Dec 2025 | Viewed by 173 | Submission Open
Keywords: precision diabetology; genomics; β -cell dysfunction; insulin resistance; pharmacogenomics
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Decoding the Epigenetic Language: Combinatorial Chromatin Modifications in Gene Regulation
edited by Kaur Gundeep and John R. Horton
submission deadline 20 Dec 2025 | Viewed by 86 | Submission Open
Keywords: epigenetics; gene regulation; chromatin modifications; chromatin architecture; computational epigenomics; CRISPR epigenome editing; epigenetic therapies
(This special issue belongs to the Section Epigenomics)
Genomic Diversity and Biological Evolution Studies of Marine Bacteria
edited by
submission deadline 20 Dec 2025 | Viewed by 57 | Submission Open
Keywords: gene; genetics; genomics; molecular biology; horizontal gene transfer; adaptation; evolution; metagenomic analysis
(This special issue belongs to the Section Microbial Genetics and Genomics)
Molecular Mechanisms Responsible for Radiation-Induced Toxicity of Normal Tissue
edited by
submission deadline 25 Dec 2025 | 7 articles | Viewed by 28235 | Submission Open
Keywords: radioresponsive genes; inflammation; genetic markers of radiation damage; immunotherapy; radioprotectors; DNA damage and repair
(This special issue belongs to the Section Toxicogenomics)
Single-Cell and Spatial Multi-Omics in Human Diseases
edited by
submission deadline 25 Dec 2025 | 3 articles | Viewed by 4823 | Submission Open
Keywords: single-cell omics; spatial multi-omics; pathogenesis of disease; biomarkers; computational tools; integrative biology
(This special issue belongs to the Section Bioinformatics)
Hereditary Traits and Diseases in Companion Animals submission deadline 25 Dec 2025 | 3 articles | Viewed by 2053 | Submission Open
Keywords: genetic traits; hereditary diseases; companion animals; spontaneous disease models; veterinary genetics; genetic selection; breed-specific diseases
(This special issue belongs to the Section Animal Genetics and Genomics)
Current Advances in Inherited Retinal Disease
edited by
submission deadline 25 Dec 2025 | 2 articles | Viewed by 1306 | Submission Open
Keywords: inherited retinal diseases; retinitis pigmentosa; macular dystrophy; cone dystrophy; genotype; gene therapy; clinical trial; imaging; genetic mechanism; genome editing; phenotype
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
The Function and Molecular Mechanism for Immune Responses in Human Diseases
edited by Zsofia Banlaki
submission deadline 25 Dec 2025 | 1 articles | Viewed by 672 | Submission Open
Keywords: leukocyte; cytokine; immune receptor; signal transduction; gene expression; antibody-antigen; major histocompatibility complex; complement system; inflammation
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Forage and Grass Genetics and Genomics
edited by Peizhi Yang, Jinghui Gao, and Tieyuan Liu
submission deadline 25 Dec 2025 | 1 articles | Viewed by 655 | Submission Open
Keywords: molecular genetics; proteomics; polyploid genomes; genotype– phenotype association analysis; forage gene editing; biotic or abiotic stress; inter-biological interactions
(This special issue belongs to the Section Plant Genetics and Genomics)
Research on Genetics and Breeding of Rice
edited by Xiaojin Luo
submission deadline 25 Dec 2025 | Viewed by 172 | Submission Open
Keywords: rice breeding; molecular genetics; rice germplasm; QTL identification and gene cloning; genetic function and genetic network; breeding technologies
(This special issue belongs to the Section Plant Genetics and Genomics)
Genomic, Transcriptome Analysis in Animals
edited by and Mengxun Li
submission deadline 25 Dec 2025 | Viewed by 128 | Submission Open
Keywords: multi-omics methodologies; genetic and epigenetic regulation; mechanisms of the elucidation of domesticated animal physiological characteristics and economic traits
(This special issue belongs to the Section Animal Genetics and Genomics)
The 15th Anniversary of Genes: Feature Papers in the Human Genomics and Genetic Diseases Section submission deadline 31 Dec 2025 | 2 articles | Viewed by 2377 | Submission Open
Keywords: genetics of monogenic diseases and complex diseases; genotype– phenotype relationships; population genomics and genetic epidemiology; precision medicine; pharmacogenetics and pharmacogenomics; targeted genome editing; gene therapy and delivery systems; genetically engineered cell therapy; RNA- and small nucleic acid-based therapeutics; genetic testing and molecular diagnostics; biomarker development and application; genome-wide association studies; epigenetic therapy; developmental genetics; epigenetics; and epigenomics
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
The 15th Anniversary of Genes: Feature Papers in the "Animal Genetics and Genomics" Section submission deadline 31 Dec 2025 | 2 articles | Viewed by 1925 | Submission Open
Keywords: applied genetics and genomics in species of economic importance; companion animal genetics and genomics; breeding and genetic selection; genetics and genomics of aquaculture species; genetics of immune response and disease resistance; genome-edited animals and animal epigenetics; animal population genetics; polymorphisms and genome annotation; genetics applied to the interaction of microbiome and genetic traits of interest; bioinformatics analysis in animal genetics; genomics and evolution; cytogenomics
(This special issue belongs to the Section Animal Genetics and Genomics)
15th Anniversary of Genes: Feature Papers in the “Cytogenomics” Section
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1774 | Submission Open
Keywords: molecular cytogenetics; cytogenomics; microarray; chromosome biology; karyotyping; high-throughput cytogenetics; genome organization; comparative genomics; karyomapping; optical mapping
(This special issue belongs to the Section Cytogenomics)
15th Anniversary of Genes: Feature Papers in the “Plant Genetics and Genomics” Section submission deadline 31 Dec 2025 | 2 articles | Viewed by 1643 | Submission Open
Keywords: epigenetic editing; genetics; genomics; pangenome; plants; QTL mapping; QTL cloning; regulation of gene expression; transcriptome
(This special issue belongs to the Section Plant Genetics and Genomics)
Genome Assembly and Annotation in Biology
edited by , and Mika Sakamoto
submission deadline 31 Dec 2025 | Viewed by 992 | Submission Open
Keywords: genome assembly; genome annotation; structural gene prediction; functional gene prediction; reference genomes; annotation tools and pipelines; comparative genomics
(This special issue belongs to the Section Bioinformatics)
Research Updates in Forensic Genetics
edited by Massimo Lancia
submission deadline 31 Dec 2025 | 1 articles | Viewed by 479 | Submission Open
Keywords: next generation sequencing; single cell analysis; time since deposition; time since death; DNA phenotyping; biogeographic ancestry; age prediction; familial search; disaster victim identification; trace DNA contextualisation
(This special issue belongs to the Section Molecular Genetics and Genomics)
The 15th Anniversary of Genes: Feature Papers in the "Population and Evolutionary Genetics and Genomics" Section submission deadline 31 Dec 2025 | Viewed by 232 | Submission Open
Keywords: population genetics; evolutionary genomics; genetic diversity; adaptation; natural selection
(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)
Genomic Data Analysis in Human Health and Disease
edited by Ighli Di Bari and
submission deadline 31 Dec 2025 | Viewed by 202 | Submission Open
Keywords: protein modeling and structure-function prediction; variant pathogenicity prediction tools; functional annotation of genetic variants; machine learning in genomics
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
The 15th Anniversary of Genes: Feature Papers in the "RNA" Section submission deadline 31 Dec 2025 | Viewed by 159 | Submission Open
Keywords: tRNAs; rRNAs; mRNAs; miRNAs; lncRNAs; sRNAs; siRNAs; RNA epigenetics; RNA modifications; RNA secondary and tertiary structure; viral RNAs; RNA binding proteins; RNA transcription; RNA translation
(This special issue belongs to the Section RNA)
The Development of Genetic Assessment for Neurotoxicity submission deadline 31 Dec 2025 | Viewed by 156 | Submission Open
Keywords: neurotoxicity; genetics; neurodegenerative disorders; mental disorders
(This special issue belongs to the Section Toxicogenomics)
Advances and Challenges in Forensic Genetics submission deadline 5 Jan 2026 | 2 articles | Viewed by 878 | Submission Open
Keywords: DNA analysis; DNA methylation applications; biogeographic ancestry; age estimation approaches; discrimination of monozygotic twins; discrimination of tissues; next-generation sequencing; forensic cases
(This special issue belongs to the Section Molecular Genetics and Genomics)
Insights into RNA Coding and Transcriptional Regulation
edited by Zihua Hu
submission deadline 5 Jan 2026 | Viewed by 251 | Submission Open
Keywords: RNA coding; transcriptomics; non-coding RNAs (ncRNA); long non-coding RNA (lncRNA); microRNA (miRNA); RNA modifications; RNA splicing; RNA editing; RNA in transcriptional and post-transcriptional regulation; gene expression regulation; scRNA
(This special issue belongs to the Section RNA)
Fragile X Syndrome and Fragile X Premutation Associated Conditions submission deadline 10 Jan 2026 | 1 articles | Viewed by 672 | Submission Open
Keywords: FMR1 gene; FMRP; fragile X syndrome; fragile X premutation-associated conditions (FXPAC); molecular mechanisms; targeted treatment and gene therapy
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Structural and Evolutionary Perspectives on Immunogenetic Variation in Autoimmune and Related Disorders
edited by Athena Andreou and Catriona Kelly
submission deadline 10 Jan 2026 | Viewed by 215 | Submission Open
Keywords: gene polymorphisms; exonic and intronic variants; structural biology; biophysical analysis; structural evolution; protein molecular function and evolution; immunological biomarkers; human genetic diseases; evolutionary genomics
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Epigenetic Mechanisms of Stem Cell Aging
edited by Romeo Blanc
submission deadline 10 Jan 2026 | Viewed by 213 | Submission Open
Keywords: stem cell aging; epigenetics; DNA methylation; histone modifications; chromatin remodeling; single-cell omics; transcriptomics; regenerative decline; cell fate decisions; tissue homeostasis
(This special issue belongs to the Section Epigenomics)
Advances in Genetic Variants in Neurological and Psychiatric Diseases
edited by
submission deadline 10 Jan 2026 | Viewed by 193 | Submission Open
Keywords: pleiotropy; comorbidity; meta-analysis; polygenic risk score; transcriptome; network analysis; psychiatric; neurology
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Germplasm Resource Evaluation and Genetic Breeding of Sheep and Goats
edited by Huihua Wang and
submission deadline 10 Jan 2026 | Viewed by 151 | Submission Open
Keywords: sheep; goat; conservation germplasm resources; genetic breeding; genomic selection; reproductive biotechnology; functional genomics
(This special issue belongs to the Section Animal Genetics and Genomics)
Cytogenetics and Cytogenomics in Clinical Diagnostics: Innovations and Applications
edited by
submission deadline 15 Jan 2026 | 6 articles | Viewed by 7606 | Submission Open
Keywords: karyotyping; cytogenomics; chromosome territory (CT); nuclear architecture; clinical oncology; germline; development; neuropsychiatry; artificial intelligence (AI)
(This special issue belongs to the Section Cytogenomics)
Phenotypic Variability of Genetic Diseases in Children
edited by Ben Pode-Shakked
submission deadline 15 Jan 2026 | 2 articles | Viewed by 2501 | Submission Open
Keywords: phenotypic variability; genetic disorders; rare diseases; neurodevelopmental disorders; craniofacial anomalies; next-generation sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Function and Regulatory Mechanism of MicroRNAs in Cancers submission deadline 15 Jan 2026 | 1 articles | Viewed by 1591 | Submission Open
Keywords: microRNAs (miRNAs); cancer biomarkers; gene regulation; miRNA-based therapies; tumor microenvironment; cancer progression; drug resistance; non-coding RNAs; epigenetic regulation; cancer immunology
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Veterinary Genetics and Genomics
edited by and
submission deadline 15 Jan 2026 | 1 articles | Viewed by 483 | Submission Open
Keywords: veterinary genetics; animal genomics; infectious diseases and disease resistance; pathogenetics; genomic selection and livestock improvement; conservation genetics; epigenetics; CRISPR gene editing; next-generation sequencing (NGS); forensic genetics; LAMP method
(This special issue belongs to the Section Animal Genetics and Genomics)
Systems Biology of Single Cells: Bridging Genomics and Functional Insights submission deadline 15 Jan 2026 | Viewed by 468 | Submission Open
Keywords: systems biology; graph theory; single-cell RNA-Seq; spatial transcriptomics; molecular networks; complex networks
(This special issue belongs to the Section Bioinformatics)
Multi-Omics in Psychiatric Disorders submission deadline 15 Jan 2026 | Viewed by 455 | Submission Open
Keywords: methylomics; transcriptomics; epigenomics; genomics; proteomics; metabolomics; multi-omics; psychiatric disorders
(This special issue belongs to the Section Neurogenomics)
The Molecular Footprint of Fetal Alcohol Spectrum Disorders and Prenatal Alcohol Exposure: Genetics, Epigenetics, Oxidative Stress and Neurodevelopement
edited by
submission deadline 15 Jan 2026 | Viewed by 286 | Submission Open
Keywords: fetal alcohol spectrum disorders; FASD; molecular biology; genetics; epigenetics; oxidative stress; neuroinflammation; neurodevelopment; pathways; diagnosis; management
(This special issue belongs to the Section Epigenomics)
Immunotherapy in Glioblastoma: Genetic Insights and Innovations submission deadline 15 Jan 2026 | Viewed by 250 | Submission Open
Keywords: glioblastoma; treatment strategy; genetic mutations; immunotherapies; checkpoint inhibitors
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Animal Virus Immunology and Genomics
edited by and
submission deadline 15 Jan 2026 | Viewed by 218 | Submission Open
Keywords: epidemiology; gene editing; genome; transcriptome; and proteome; synthetic biology; high-throughput sequencing; multi-omics; transcription factor; immunology
(This special issue belongs to the Section Animal Genetics and Genomics)
Integrating Traditional and Modern Technology for Cattle Genetic Improvement
edited by and
submission deadline 15 Jan 2026 | Viewed by 213 | Submission Open
Keywords: cattle breeding; animal genetics; genomic selection; functional genomics; epigenetics and epigenomics; functional genes; Quantitative Trait Loci (QTL)
(This special issue belongs to the Section Animal Genetics and Genomics)
Next-Generation Diagnosis and Treatment of Hematologic Diseases submission deadline 15 Jan 2026 | Viewed by 202 | Submission Open
Keywords: hematologic disease; hematology; thrombosis and hemostasis; bleeding disorders; artificial intelligence; next-generation theranostics; therapeutics; diagnostics; peptide design; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetic and Epigenetic Mechanisms Underlying Cancer Stem Cells and Their Implications for Novel Therapeutic Approaches submission deadline 15 Jan 2026 | Viewed by 197 | Submission Open
Keywords: cancer stem cell; metastasis; cancer-associated gene; model organism for cancer research; therapeutics
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetic Insights into Aortic Aneurysm Disease
edited by and Bulat A. Ziganshin
submission deadline 15 Jan 2026 | Viewed by 196 | Submission Open
Keywords: aneurysm; thoracic aortic aneurysm; abdominal aortic aneurysm; aorta; thoracic aorta; genetics; aortic syndromes; Marfan; Loeys– Dietz; Ehlers– Danlos; aortopathy; medial degeneration; aneurysm genes
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Next-Gen Omics in Animal and Microbial Science
edited by Loan To Nguyen
submission deadline 15 Jan 2026 | Viewed by 120 | Submission Open
Keywords: Oxford nanopore technologies; genomics; transcriptomics; metagenomics; microbiome
(This special issue belongs to the Section Animal Genetics and Genomics)
Molecular and Genetic Mechanisms of Floral Development
edited by Kaifeng Ma
submission deadline 16 Jan 2026 | Viewed by 89 | Submission Open
Keywords: floral induction and differentiation; flower bud formation and dormancy; floral organ; flower pattern; flower color and fragrance; blooming period; molecular and genetic mechanism
(This special issue belongs to the Section Plant Genetics and Genomics)
Genetic Studies on Cotton Stress Resistance, Quality Traits, and Drought Response Mechanisms
edited by Xueyuan Li, Juyun Zheng, and Fenglei Sun
submission deadline 20 Jan 2026 | 1 articles | Viewed by 798 | Submission Open
Keywords: cotton; drought stress; growth and development; gene editing; molecular marker-assisted selection
(This special issue belongs to the Section Plant Genetics and Genomics)
Advances in Molecular Genetics of Psychiatric Diseases
edited by Fotis Tsetsos
submission deadline 20 Jan 2026 | 1 articles | Viewed by 547 | Submission Open
Keywords: psychiatric genetics; molecular psychiatry; GWAS; rare variants; transcriptomics; epigenetics; gene-environment interactions; precision psychiatry; schizophrenia; bipolar disorder; depression; autism spectrum disorder; anxiety; functional genomics; neurodevelopmental disorders
(This special issue belongs to the Section Molecular Genetics and Genomics)
Cytogenetics/Cytogenomics and Functional Genomics in Human Health and Disease submission deadline 20 Jan 2026 | Viewed by 291 | Submission Open
Keywords: functional genomics; cytogenetics; cytogenomics; microarray; optical genome mapping (OGM); Hi-C; genomic proximity mapping (GPM); intergenic; topologically associating domains (TAD); expression
(This special issue belongs to the Section Cytogenomics)
New Insight into the Genetic and Molecular Aspects of Yeast Nutrient Metabolism
edited by Roman Maslanka and
submission deadline 20 Jan 2026 | Viewed by 277 | Submission Open
Keywords: yeasts as a model organism; yeast metabolism; nutrient sensing; sugar/hexose transport; central carbon metabolism; catabolite repression; nutrient availability; resource allocation; calorie restriction; cAMP-PKA signaling; metabolic flux; metabolic adaptation; genetic and transcriptional regulation; cellular homeostasis; molecular biology of yeast
(This special issue belongs to the Section Molecular Genetics and Genomics)
Reviews in Genetic Bioinformatics: Tools and Analyses
edited by
submission deadline 20 Jan 2026 | Viewed by 247 | Submission Open
Keywords: genetics; genomics; machine learning; computational biology; big data; bioinformatics
(This special issue belongs to the Section Bioinformatics)
Application of Bioinformatics in Complex Traits
edited by
submission deadline 20 Jan 2026 | Viewed by 143 | Submission Open
Keywords: complex traits; bioinformatics; multi-omics integration; gene– environment interactions; polygenic risk scores; machine learning; systems biology; network analysis; statistical genetics; causal inference
(This special issue belongs to the Section Bioinformatics)
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