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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genomics and Functional Genetics of Marine Shrimp Adaptation and Breeding

edited by Jiajia Wang

submission deadline 15 Mar 2027 | Viewed by 356 | Submission Open

Keywords: shrimp; aquaculture; genomics; functional genetics; environmental adaptation; disease resistance; genetic breeding; stress response; molecular mechanisms; genomic selection

(This special issue belongs to the Section Animal Genetics and Genomics)

Molecular Basis and Gene Therapy of Cystic Fibrosis

edited by

Beate Illek

submission deadline 15 Mar 2027 | Viewed by 210 | Submission Open

Keywords: genomic medicine & cystic fibrosis; CFTR gene therapy; CRISPR-based editing (HDR/base/prime); mRNA & antisense oligonucleotide (ASO) therapeutics; NMD & miRNA inhibitors; viral vectors; SORT-LNPs (selective ORgan targeting); inhaled & systemic targeted delivery; vascularized & CF cell/animal models; inflammatory gene therapy barriers

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

From Pediatrics to Late-Onset Phenotypes: Closing the Diagnostic Gap in Rare Diseases Through Advanced Molecular Testing

edited by

Lǎcrǎmioara Ionela Butnariu

submission deadline 15 Mar 2027 | Viewed by 193 | Submission Open

Keywords: pediatric genetics; late-onset phenotypes; genetic diagnostic gap; Whole-Exome Sequencing (WES); Whole-Genome Sequencing (WGS); RNA-seq; variants of uncertain significance (VUSs); long-read sequencing; diagnostic odyssey; multi-omics integration

(This special issue belongs to the Section Genetic Diagnosis)

Application of Bioinformatics in Crop Genetic Improvement

edited by Jin Wang and Tongkun Liu

submission deadline 15 Mar 2027 | Viewed by 161 | Submission Open

Keywords: bioinformatics; genomics; crop genetic improvement; crop breeding; biotechnology

(This special issue belongs to the Section Plant Genetics and Genomics)

Molecular Genetics and Breeding Strategies in Crops

edited by Guanghui Guo

submission deadline 15 Mar 2027 | Viewed by 107 | Submission Open

Keywords: marker-assisted selection; genomic selection; genome editing; transgenic; stress; speed breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Environmental Genomics and Low-Dose Induced Adaptive Response: Underlying Mechanisms from Cells to Organisms

edited by

Stephka Chankova

, Michaela Beltcheva and

Teodora Todorova

submission deadline 20 Mar 2027 | 4 articles | Viewed by 3844 | Submission Open

Keywords: environmental genomics; ecotoxicology; low-dose induced adaptive response; low-dose radiation; genomic instability; environmental mutagenesis; DNA repair; radio-protection; stress response; toxicogenomics; antioxidant system; chaperone system

(This special issue belongs to the Section Genes & Environments)

Advances in Molecular Genetics of Rare Disorders

edited by Miriam Lucia Carriero

submission deadline 20 Mar 2027 | 4 articles | Viewed by 3096 | Submission Open

Keywords: rare diseases; molecular genetics; gene–disease associations; genotype–phenotype correlation; targeted gene therapy; next-generation sequencing; whole-genome sequencing; genome-wide association studies; functional genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Fetal Genetic Disorders: Diagnosis and Therapy

edited by Gianluca Campobasso

submission deadline 20 Mar 2027 | 2 articles | Viewed by 1712 | Submission Open

Keywords: fetal medicine; malformations,; genetic anomalies,; genomic sequencing,; syndromes; artificial intelligence

(This special issue belongs to the Section Genetic Diagnosis)

Decoding Male Infertility: Genomics, Non-Coding RNAs and Multi-Omics Approaches

edited by

Zissis Mamuris

and

Maria-Anna Kyrgiafini

submission deadline 20 Mar 2027 | 2 articles | Viewed by 834 | Submission Open

Keywords: male infertility; non-coding RNAs; genomics; multi-omics; precision reproductive medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Forest Tree Genetics: Genetic Improvement and Breeding

edited by

Hanbo Yang

and

Wenquan Bao

submission deadline 20 Mar 2027 | 1 articles | Viewed by 376 | Submission Open

Keywords: forest genetics; genetic improvement; tree breeding; germplasm resources; molecular markers; genomic selection; stress-resistance breeding; wood property improvement; genetic diversity; functional genomics

(This special issue belongs to the Section Plant Genetics and Genomics)

Genomics and Computational Biology in Human Leukemia

edited by Veronique Voisin

submission deadline 20 Mar 2027 | Viewed by 164 | Submission Open

Keywords: leukemia genomics; single-cell transcriptomics; computational oncology; multi-omics integration; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Fungal Pathogen Genetics

edited by

Shuaishuai Huang

and

Víctor J. Cid

submission deadline 20 Mar 2027 | Viewed by 122 | Submission Open

Keywords: fungal pathogen; host–pathogen interaction; transcriptomics; genomics; epigenetics; multi-omics; evolution; stress response; development

(This special issue belongs to the Section Microbial Genetics and Genomics)

Integrative Multi-Omics Approaches in Disease Mapping: From Genetic Variation to Protein Regulation and Post-Translational Modifications

edited by

Shrabanti Chowdhury

submission deadline 20 Mar 2027 | Viewed by 106 | Submission Open

Keywords: proteogenomics; post-translational modifications; multi-omics integration; disease mapping; causal inference; machine learning in omics; biomarker discovery

(This special issue belongs to the Section Bioinformatics)

Advances in Genetics and Genomics of Medical Plants

edited by

Mingcheng Wang

submission deadline 25 Mar 2027 | 3 articles | Viewed by 2281 | Submission Open

Keywords: medicinal plant genomics; medicinal plant genetics; high-throughput sequencing; functional genomics; multi-omics integration

(This special issue belongs to the Section Plant Genetics and Genomics)

Forage Crop Genetics Improvement and Breeding

edited by Enjun Xu

submission deadline 25 Mar 2027 | Viewed by 155 | Submission Open

Keywords: forage crops; forage genomics; biomass yield; abiotic stress tolerance; forage quality/nutritional quality; genetic transformation; genome editing/gene editing; germplasm innovation

(This special issue belongs to the Section Plant Genetics and Genomics)

Innovations in Aquaculture Breeding via Genetic Technologies

edited by

Lei Liu

submission deadline 5 Apr 2027 | 2 articles | Viewed by 2367 | Submission Open

Keywords: aquaculture species; molecular breeding; genomic; behavioral traits; reproduction and development; genome editing; whole-genome sequencing

(This special issue belongs to the Section Animal Genetics and Genomics)

Abiotic Stress in Plant: Molecular Genetics and Genomics

edited by Weicong Qi and

Hongyan Wang

submission deadline 10 Apr 2027 | 10 articles | Viewed by 10023 | Submission Open

Keywords: abiotic stress; molecular genetics; genomics; plant stress response; epigenetics; crop improvement; sustainable agriculture

(This special issue belongs to the Section Plant Genetics and Genomics)

Molecular Evolution and Mitochondrial Genomics in Animals

edited by

Jiayong Zhang

submission deadline 10 Apr 2027 | 2 articles | Viewed by 1532 | Submission Open

Keywords: mitochondrial genome; gene arrangement; phylogenetic relationship; mitochondrial gene expression; molecular evolution

(This special issue belongs to the Section Animal Genetics and Genomics)

Epigenetic Regulation of Transcription in Eukaryotes

edited by Ralph Grand

submission deadline 10 Apr 2027 | Viewed by 347 | Submission Open

Keywords: epigenetics; nucleosomes; chromatin; transcription; development; disease

(This special issue belongs to the Section Epigenomics)

Computational Genomics and Bioinformatics of Cancer

edited by

Ilya Ioshikhes

submission deadline 15 Apr 2027 | 14 articles | Viewed by 25234 | Submission Open

Keywords: cancer; data analysis; bioinformatics; complex diseases; dimensionality reduction; genetics; epigenetics; gene regulation; molecular mechanism; environmental factors

(This special issue belongs to the Section Bioinformatics)

Genetic and Genomic Mechanisms of Heat Stress in Disease Modulation: From Molecular Pathways to Clinical Manifestations

edited by

Hisahide Nishio

and

Hiroyuki Awano

submission deadline 15 Apr 2027 | 1 articles | Viewed by 2608 | Submission Open

Keywords: heatstroke; global warming; heat stress; neurodegenerative diseases; molecular pathogenesis; gene–environment interactions

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Systems Biology of Single Cells: Bridging Genomics and Functional Insights

edited by

Guilherme Targino Valente

submission deadline 15 Apr 2027 | 2 articles | Viewed by 2605 | Submission Open

Keywords: systems biology; graph theory; single-cell RNA-Seq; spatial transcriptomics; molecular networks; complex networks

(This special issue belongs to the Section Bioinformatics)

Genetics and Breeding of Tea Tree and Tea Plant

edited by Lianyu Yuan

submission deadline 15 Apr 2027 | 2 articles | Viewed by 1822 | Submission Open

Keywords: gene function analysis; genome analysis; biotechnological breeding; genetic diversity; breeding technology; multi-omics analysis; tea plant

(This special issue belongs to the Section Plant Genetics and Genomics)

Regulation of DNA Integrity

edited by

Luciano D'Agostino

and

Karen M. Vasquez

submission deadline 15 Apr 2027 | 1 articles | Viewed by 919 | Submission Open

Keywords: preservation of gene functions; genomic protection; functioning of DNA structures; epigenomics; gene integrity in DNA engineering; genomic artificial structures; DNA damaging; DNA repairing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gene Regulatory Networks in Hematologic Malignancies and Cancer

edited by Renee M. Demarest

submission deadline 15 Apr 2027 | 2 articles | Viewed by 842 | Submission Open

Keywords: gene regulatory networks; hematologic malignancies; cancer genomics; transcriptional regulation; epigenetic regulation; hematopoiesis; single-cell sequencing; systems biology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Telomere Biology: From Mechanisms of Genome Stability to Cancer

edited by Marta Dratwa-Kuzmin and Katarzyna Bogunia-Kubik

submission deadline 15 Apr 2027 | 1 articles | Viewed by 491 | Submission Open

Keywords: telomeres; genome stability; chromosomal instability; telomerase; alternative lengthening of telomeres (ALT); DNA damage response; DNA repair; replication stress; cellular senescence; cancer biology; tumor progression; ageing; chromatin organization; telomere dysfunction; cancer therapeutics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Decoding the Epigenomic Basis of Gene Regulation in Cancer

edited by Alireza Lorzadeh

submission deadline 15 Apr 2027 | 1 articles | Viewed by 471 | Submission Open

Keywords: epigenetic enhancer dynamics; epigenetic stem cell plasticity; epigenetic single-cell multi-omics; epigenetic disease heterogeneity; epigenetic gene regulatory networks; AI-driven epigenetic analysis; epigenetic precision medicine

(This special issue belongs to the Section Epigenomics)

Molecular and Genomic Testing in Hematology: From Diagnosis to Disease Monitoring

edited by

Rina Kansal

submission deadline 15 Apr 2027 | Viewed by 71 | Submission Open

Keywords: hematology; pathology; genomics; next-generation sequencing; hematologic malignancies; anemia; measurable residual disease; circulating tumor DNA; machine learning

(This special issue belongs to the Section Genetic Diagnosis)

Genomics, Climate Adaptation and Precision Breeding in Animals

edited by

Themistoklis Giannoulis

submission deadline 20 Apr 2027 | 1 articles | Viewed by 409 | Submission Open

Keywords: climate adaptation; genomic selection; livestock genomics; heat stress; precision breeding; sustainability

(This special issue belongs to the Section Animal Genetics and Genomics)

Epigenomic and Genomic Studies of Cancers

edited by Yuxiang Wang

submission deadline 20 Apr 2027 | Viewed by 306 | Submission Open

Keywords: cancer; mutation; amplification; deletion; epigenetics; 3D epigenetics; next-generation sequencing; ChIP-seq; Hi-C; DamID; sequential FISH; SPRITE; GAM

(This special issue belongs to the Section Epigenomics)

Application of Genetics and Genomics in Plant–Pathogen Interactions

edited by Wei Jiang and

Zengtao Zhong

submission deadline 20 Apr 2027 | Viewed by 43 | Submission Open

Keywords: genetics; genomics; adaptive evolution; biological control; molecular plant–microbe interactions; stress resistance; comparative genomics

(This special issue belongs to the Section Plant Genetics and Genomics)

Advances in Genetic Insights into Cardiovascular Diseases

edited by

John Alex Elefteriades

submission deadline 25 Apr 2027 | 2 articles | Viewed by 561 | Submission Open

Keywords: cardiovascular genetics; causative genes; whole exome sequencing; genotype–phenotype correlation; precision therapy; pharmacogenetics in CVD; gender medicine in CVD

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

3D Chromatin Architecture: From Computational Algorithms to Biological Functions

edited by

Minji Kim

submission deadline 25 Apr 2027 | Viewed by 273 | Submission Open

Keywords: 3D genomics; computational algorithm; genome organization; gene regulation; molecular mechanism; functional elements

(This special issue belongs to the Section Bioinformatics)

Genetics and Gene Regulation of Atrial Fibrillation and Other Cardiology

edited by Weijia Luo

submission deadline 25 Apr 2027 | Viewed by 84 | Submission Open

Keywords: atrial fibrillation; cardiac arrhythmias; cardiomyopathies and heart failure; functional genomics; gene regulatory networks epigenetics and epigenomics; multi-omics integration; genome editing and CRISPR applications; biomarker discovery; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Bioinformatics of Genome Regulation

edited by

Kenta Nakai

Hongyan Xu

and

Martin Loza

submission deadline 25 Apr 2027 | Viewed by 73 | Submission Open

Keywords: epigenomics; transcriptional regulation; single-cell multi-omics; deep learning; gene regulatory networks; chromatin architecture; genome grammar

(This special issue belongs to the Section Bioinformatics)

DNA Replication Fidelity and Dynamics in Cancer

edited by

Francesca Citron

submission deadline 25 Apr 2027 | Viewed by 71 | Submission Open

Keywords: DNA replication; DNA damage and repair; epigenetics; genomic instability; immune response; immunotherapy; tumor evolution

(This special issue belongs to the Section Molecular Genetics and Genomics)

Abiotic Stress in Plants: Genetics and Genomics

edited by

Jing Xu

submission deadline 25 Apr 2027 | Viewed by 61 | Submission Open

Keywords: abiotic stress; genetics; genomics; molecular mechanisms; plant hormones; plant growth and development; multi-omics; stress tolerance; molecular breeding; population

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Mechanisms of Hormonal Regulation in Insect Development and Metamorphosis

edited by

Tao Geng

submission deadline 25 Apr 2027 | Viewed by 57 | Submission Open

Keywords: insect development; insect metamorphosis; hormonal regulation; gene regulation; behavior; epigenetics

(This special issue belongs to the Section Animal Genetics and Genomics)

Approaches to Genome and Epigenome Sequencing Data Analysis: From Innovation to Application

edited by Yao Yang and Wanqiong Qiao

submission deadline 5 May 2027 | 1 articles | Viewed by 1326 | Submission Open

Keywords: genome; epigenome; next-generation sequencing (NGS); long-read sequencing; single-cell sequencing; whole-genome sequencing; epigenome sequencing; DNA methylation; methylome

(This special issue belongs to the Section Technologies and Resources for Genetics)

RNA Interference—Small RNAs in Biomedicine

edited by

Tamas Orban

submission deadline 5 May 2027 | Viewed by 518 | Submission Open

Keywords: RNAi; miRNA; siRNA; piRNA; extracellular vesicle; vesicular miRNA; biofluids; blood miRNA; serum miRNA; urine miRNA; saliva miRNA; miRNA therapy; siRNA therapy

(This special issue belongs to the Section RNA)

Advanced Research in Forensic Genetics—2nd Edition

edited by

Mauro Pesaresi

submission deadline 10 May 2027 | 4 articles | Viewed by 1873 | Submission Open

Keywords: forensic genetics; massive parallel sequencing (MPS); DNA quantification methods; DNA extraction methods; sudden cardiac death; post-mortem interval; microRNA; DNA phenotyping; individual identification; genetic markers; short tandem repeats (STR); single nucleotide polymorphism (SNP); mitochondrial DNA (mtDNA); microhaplotype; forensic statistics; artificial intelligence; activity level in forensics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Alternative Splicing in Genetic Disorders and Cancer

edited by

Giuseppina Covello

submission deadline 10 May 2027 | 2 articles | Viewed by 1374 | Submission Open

Keywords: alternative splicing (AS); genetic disorders; key cancer-related genes; aberrant splicing; therapeutic approaches

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in CRISPR-Cas Genome Editing

edited by Lijun Cheng

submission deadline 10 May 2027 | Viewed by 64 | Submission Open

Keywords: CRISPR-Cas genome editing; CRISPR screening; functional genomics; CRISPR interference (CRISPRi); CRISPR activation (CRISPRa); synthetic lethality; artificial intelligence; precision medicine; single-cell genomics; spatial transcriptomics; drug discovery; RNA target discovery

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genomic and Molecular Mechanisms of Inherited Retinal Diseases: From Molecular Insights to Clinical Practice and Diagnosis

edited by

Raffaella Cascella

submission deadline 10 May 2027 | Viewed by 57 | Submission Open

Keywords: IRDs; genomics; molecular mechanisms; genetic diagnosis; genotype–phenotype correlation; high-throughput technologies (NSG, LRS); precision medicine; clinical translation; therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

New Advances in Computational Regulatory Genomics

edited by

Sourav Roy

submission deadline 10 May 2027 | Viewed by 55 | Submission Open

Keywords: promoters; gene expression; gene regulation; GWAS; computational algorithms

(This special issue belongs to the Section Bioinformatics)

Hereditary Traits and Diseases in Companion Animals

edited by

Lucie Chevallier

and

Marie Abitbol

submission deadline 15 May 2027 | 5 articles | Viewed by 10384 | Submission Open

Keywords: genetic traits; hereditary diseases; companion animals; spontaneous disease models; veterinary genetics; genetic selection; breed-specific diseases

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic and Molecular Mechanisms of Aging and Their Role in Cancer

edited by Eleni A. Georgakopoulou and

Konstantinos Evangelou

submission deadline 15 May 2027 | Viewed by 375 | Submission Open

Keywords: aging; cancer; cellular senescence; immunosenescence; senescence-associated secretory phenotype (SASP); DNA damage response; genomic instability; chronic inflammation (inflammaging); senolytics and senomorphics; healthy longevity; mtDNA mutations in aging; sex differences in lifespan

(This special issue belongs to the Section Molecular Genetics and Genomics)

RNA Processing and Regulation in Human Inherited Disorders

edited by Mallory A. Havens and

Laurent Metzinger

submission deadline 15 May 2027 | Viewed by 68 | Submission Open

Keywords: antisense oligonucleotides; splicing switch oligonucleotides; pre-mRNA alternative splicing in disease; non-canonical RNA in genetics disorders; RNA processing

(This special issue belongs to the Section RNA)

Pathogenic Variants and Genomic Mechanisms in Diseases

edited by Arpad M. Danos

submission deadline 15 May 2027 | Viewed by 66 | Submission Open

Keywords: variant interpretation; bioinformatics; mathematical biology; CIViC knowledgebase

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Genetics and Genomics of Complex Traits and Diseases

edited by Irman Forghani

submission deadline 15 May 2027 | Viewed by 65 | Submission Open

Keywords: complex traits and diseases; polygenic risk and prediction; genome‑wide and sequencing‑based studies; multi‑omics and integrative genomics; functional genomics and variant interpretation; gene–environment interactions; translational genomics and clinical implementation; precision medicine and risk stratification; diverse populations and health equity

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

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