Special Issue "Computational Analysis of RNA Structure and Function"
Deadline for manuscript submissions: closed (30 April 2018)
RNA, the matter of transcripts, is being intensively studied across all living organisms in numerous ways, ranging from analysis of its structure and folding properties to high-throughput sequencing (HTS) and its applications, including those targeting interactions and structure itself. Indeed, RNA often folds into complex structures central to its function by, which, for example, function through binding to other RNAs and proteins. Hence, the relevance of predicting both RNA structure and RNA interactions does not only concern structure determination of single sequences, but do also addresses analysis of large-scale data sets. Efficient algorithms and implementations are also essential to meet the demand of large-scale applications. Another challenge is that algorithms for RNA structure and interaction analysis are relatively computational expensive, for example when compared to their counterpart of sequence alignments. Furthermore, the vast majority of trait and disease related mutations in higher eukaryotes are located in non-coding regions of the genome and since most of the genome is transcribed into RNA, the mutations hold the potential impact structure and thereby function of the RNA molecules. This Special Issue includes computational strategies for analysis of RNA structure and function covering both algorithmic aspects, as well as bioinformatic analysis large-scale related data sets.
Prof. Dr. Jan Gorodkin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- RNA structure (2D and 3D)
- RNA folding and dynamics
- RNA interactions
- Comparative structure analysis
- Analysis of large scale data sets related to RNA structure
- RNA structure and mutations
- RNA modification
- RNA structure and expression