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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tuberculosis Detection and Diagnosis 2025

edited by

Kanagavel Murugesan

submission deadline 30 Dec 2025 | 3 articles | Viewed by 7429 | Submission Open

Keywords: immunological testing: TST; IGRA; microscopic testing: sputum smear microscopy; AFB staining; molecular testing: NAATs; including LAMP and GeneXpert MTB/RIF; fluorescence in situ hybridization (FISH); culture-based testing: BACTEC MGIT; imaging techniques: X-rays; CT; advanced testing technologies: NGS; mass spectrometry

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Advances in Anatomy—Third Edition

edited by

Kyu-ho Yi

submission deadline 31 Dec 2025 | 23 articles | Viewed by 131644 | Submission Open

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in the Diagnosis of Gastrointestinal Diseases—2nd Edition

edited by

Huarong Chen

submission deadline 31 Dec 2025 | 21 articles | Viewed by 72026 | Submission Open

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Machine-Learning-Based Disease Diagnosis and Prediction

edited by Fakhar Abbas

submission deadline 31 Dec 2025 | 25 articles | Viewed by 52941 | Submission Open

Keywords: development and validation of machine learning models for disease diagnosis and prediction; integration of multimodal data (e.g.; imaging; genomic; and clinical) for enhanced diagnostic accuracy; artificial intelligence in healthcare; ethical and regulatory considerations in the deployment of machine learning for healthcare applications; case studies and applications of machine learning in specific disease domains (e.g.; cancer; cardiovascular diseases; and neurodegenerative disorders); comparative studies and benchmarking of machine learning approaches for disease diagnosis and prediction; healthcare analytics; bioinformatics; medical imaging analysis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in the Diagnostic Imaging of Gastrointestinal Diseases

edited by

Adrian Saftoiu

Bogdan Silviu Ungureanu

and

Irina M. Cazacu

submission deadline 31 Dec 2025 | 14 articles | Viewed by 45062 | Submission Open

Keywords: gastrointestinal diseases; gastrointestinal malignancies; endoscopy; endoscopic ultrasound; confocal laser endomicroscopy; ERCP; ultrasound; CEUS; CT; MRI

(This special issue belongs to the Section Medical Imaging and Theranostics)

Assessment and Diagnosis of Cognitive Disorders

edited by

Elena Cecilia Rosca

submission deadline 31 Dec 2025 | 8 articles | Viewed by 32489 | Submission Open

Keywords: cognitive disorders; neurology; neuroimaging; biomarkers; diagnosis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Artificial Intelligence in Healthcare

edited by

Kelvin K. L. Wong

and

Dhanjoo N. Ghista

submission deadline 31 Dec 2025 | 8 articles | Viewed by 26746 | Submission Open

Keywords: artificial intelligence; AI-driven radiomics; healthcare; digital radiology; precision medicine

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Orthopedics and the Musculoskeletal System: Diagnosis, Prognosis, and Mechanisms

edited by Nahum Rosenberg

submission deadline 31 Dec 2025 | 11 articles | Viewed by 24149 | Submission Open

Keywords: muscle biology; muscle rehabilitation; orthopedic imaging; orthopedic diagnosis; orthopedic trauma; fracture healing

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

New Developments in the Diagnosis of Skin Tumors

edited by

Sorina Danescu

submission deadline 31 Dec 2025 | 7 articles | Viewed by 23133 | Submission Open

Keywords: basal cell carcinoma; melanoma; benign tumors; cutaneous squamous cell carcinoma; Bowen’ s disease; actinic keratosis; diagnosis; biomarkers; imaging techniques; molecular diagnostics; histopathology; precision medicine

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Fetal Diagnosis and Therapy

edited by Elisa Montaguti

submission deadline 31 Dec 2025 | 5 articles | Viewed by 20727 | Submission Open

Keywords: ultrasound; prenatal diagnosis; NIPT; fetal echocardiography; fetal therapy; fetal MRI

(This special issue belongs to the Section Medical Imaging and Theranostics)

Artificial Intelligence Advances for Medical Computer-Aided Diagnosis—2nd Edition

edited by

Mugahed A. Al-antari

submission deadline 31 Dec 2025 | 6 articles | Viewed by 19490 | Submission Open

Keywords: image classification; image segmentation; medical image processing; biomedical optical imaging; medical signal processing; artificial intelligence; deep learning; machine learning; computer-aided diagnosis; explainable artificial intelligence

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Inflammatory Pathologies

edited by Uday Nagesh Shivaji

submission deadline 31 Dec 2025 | 7 articles | Viewed by 18985 | Submission Open

Keywords: systemic chronic inflammation; biomarkers of inflammation; imaging in inflammatory pathology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Artificial Intelligence in Pathological Image Analysis—2nd Edition

edited by

Masayuki Tsuneki

submission deadline 31 Dec 2025 | 7 articles | Viewed by 17369 | Submission Open

Keywords: histopathology; cytopathology; molecular pathology; surgical pathology; digital pathology; microscopy; whole slide image (WSI); clinical data; computer vision; deep learning; machine learning; computation; mathematics; domain adaptation; segmentation; classification; pattern recognition; explainable AI; reconstruction

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Latest Advances and Prospects in Cardiovascular Imaging

edited by Carlo Liguori

submission deadline 31 Dec 2025 | 6 articles | Viewed by 17230 | Submission Open

Keywords: cardiovascular imaging; cardiovascular magnetic resonance; coronary angiography; echocardiography; artificial intelligence

(This special issue belongs to the Section Medical Imaging and Theranostics)

Artificial Intelligence for Clinical Diagnostic Decision Making

edited by

Md Mohaimenul Islam

and

Ming-Chin Lin

submission deadline 31 Dec 2025 | 5 articles | Viewed by 16696 | Submission Open

Keywords: artificial intelligence; machine learning; clinical decision support systems; health disparity; medical imaging; disease diagnosis; medical errors; patient safety

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Neurological Diseases: Biomarkers, Diagnosis and Prognosis

edited by

Theodosis Kalamatianos

submission deadline 31 Dec 2025 | 10 articles | Viewed by 15410 | Submission Open

Keywords: biomarkers; neurological diseases; multiple sclerosis; traumatic brain injury; peripheral neuropathies; COVID-19 neurological-associated damage; diagnosis; prognosis.

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Current Challenges and Perspectives of Ultrasound, 2nd Edition

edited by

Christoph Frank Dietrich

submission deadline 31 Dec 2025 | 5 articles | Viewed by 14394 | Submission Open

Keywords: ultrasound; contrast-enhanced ultrasound (CEUS); endoscopic ultrasound; strain imaging; shear wave elastography; fusion imaging; endoscopic ultrasound

(This special issue belongs to the Section Medical Imaging and Theranostics)

The Role of AI in Ultrasound

edited by

Hyuksool Kwon

submission deadline 31 Dec 2025 | 6 articles | Viewed by 13930 | Submission Open

Keywords: artificial intelligence; medical ultrasound; diagnostic imaging; automated image interpretation; predictive modeling; personalized medicine; clinical workflow optimization; healthcare access; multidisciplinary innovation

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Clinical Presentation, Management and Prognosis of Infective Endocarditis

edited by

Arian Arjomandi Rad

, Alexander Weymann and Thanos Athanasiou

submission deadline 31 Dec 2025 | 2 articles | Viewed by 13737 | Submission Open

Keywords: infective endocarditis; clinical presentation; diagnostic modalities; antibiotic stewardship; surgical interventions; prognostic indicators

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Optical Imaging: Trends, Impact, and Application in Medical and Biomedical Diagnostics

edited by

Naresh Kumar Ravichandran

submission deadline 31 Dec 2025 | 7 articles | Viewed by 13454 | Submission Open

Keywords: vascular and tumor imaging; drug testing; blood flow characterization; tissue characterization and cell migration analysis; fluorescence microscopy (FM); optical coherence tomography (OCT); ultrasound imaging (sonography); multiphoton microscopy (MPM); photoacoustic tomography (PAT); computed tomography (CT); conebeam computed tomography (CBCT); magnetic resonance imaging (MRI); endoscopy; scanning laser ophthalmoscopy; super-resolution microscopy; hyperspectral imaging; diffuse optical tomography; spectroscopy; structured illumination microscopy (SIM); laser doppler imaging; artificial intelligence; machine learning; algorithm development

(This special issue belongs to the Section Biomedical Optics)

Advances in the Diagnosis and Management of Neuropsychiatric Disorders—2nd Edition

edited by

Jesús Ramírez-Bermúdez

submission deadline 31 Dec 2025 | 4 articles | Viewed by 12507 | Submission Open

Keywords: neuropsychiatric disorders; autism; mania; depression; imaging; diagnosis; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Recent Advances and Challenges in Gastrointestinal Endoscopy

edited by

Toshiro Iizuka

submission deadline 31 Dec 2025 | 6 articles | Viewed by 12126 | Submission Open

Keywords: diagnosis at an early stage; endoscopy; precancerous lesion

(This special issue belongs to the Section Biomedical Optics)

Novel Methods and Devices for Monitoring and Diagnosing in Critical Care

edited by

Zhongheng Zhang

submission deadline 31 Dec 2025 | 7 articles | Viewed by 11634 | Submission Open

Keywords: hemodynamic monitoring; perfusion; heart-lung interactions; novel biomarkers; machine learning; ultrasound; therapeutic drug monitoring; wearable sensors

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Advances in Computed Tomography Imaging for Clinical Diagnosis—2nd Edition

edited by Ibrahim Yel

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11574 | Submission Open

Keywords: computed tomography imaging; clinical diagnosis; dual-energy CT; photon-counting CT; image analysis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Genetic and Genomic Biomarkers in Cancer Diagnosis, Prognosis, and Treatment Prediction

edited by

Jianli Dong

submission deadline 31 Dec 2025 | 7 articles | Viewed by 10816 | Submission Open

Keywords: cancer genetics and genomics; diagnostic tests; prognostic tests; predictive tests; nucleic acid; companion diagnostics; targeted therapy

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Current Issues on Kidney Diseases Diagnosis and Management 2025

edited by

Luis Yu

submission deadline 31 Dec 2025 | 6 articles | Viewed by 10778 | Submission Open

Keywords: kidney diseases; renal involvement; AKI; CKD; glomerulopathies; diagnosis; treatment; dialysis; epidemiology; nephritic syndrome; nephrotic syndrome; biomarkers; urinalysis; oliguria; poliuria; electrolytes; acid-base balance

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advancements in Diagnostic Tools in the Emergency Department (ED): A Possible Help to Avoid Overcrowding

edited by Jacopo M. Legramante

submission deadline 31 Dec 2025 | 2 articles | Viewed by 10552 | Submission Open

Keywords: critical care; emergency medicine; diagnostics

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnostic and Prognostic Markers in Liver Diseases

edited by

Dávid Tornai

submission deadline 31 Dec 2025 | 5 articles | Viewed by 10392 | Submission Open

Keywords: diagnostic and prognostic markers; non-invasive biomarkers; hepatology; liver disease; therapeutic response; disease progression; fibrosis; mortality; decompensation; infection

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in the Diagnosis of Infectious Diseases and Microorganisms: 2nd Edition

edited by

Philippe Colson

submission deadline 31 Dec 2025 | 7 articles | Viewed by 10282 | Submission Open

Keywords: clinical microbiology; antimicrobial resistance; diagnostic microbiology; molecular microbiology; HIV; infectious diseases

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Nephrology: Diagnosis and Management

edited by Elio Antonucci

submission deadline 31 Dec 2025 | 6 articles | Viewed by 10250 | Submission Open

Keywords: kidney disease; nephropathy; diagnosis management; renal disease

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in the Diagnosis and Management of Breast Cancer

edited by

Fulvio Borella

and

Isabella Castellano

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10235 | Submission Open

Keywords: prognostic and predictive factors; breast carcinoma; phylloid tumor; immunohistochemistry; diagnosis; breast cancer

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Skin and Cutaneous Adnexal Tumors: Diagnosis and Management—2nd Edition

edited by

Andreas Manios

and

Dimitra Koumaki

submission deadline 31 Dec 2025 | 2 articles | Viewed by 9618 | Submission Open

Keywords: cutaneous adnexal tumors; follicular and sebaceous tumors; sweat gland tumors

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Pathology and Diagnosis of Gynecologic Diseases, 3rd Edition

edited by

Cinzia Giacometti

and Mariateresa Mirandola

submission deadline 31 Dec 2025 | 5 articles | Viewed by 9549 | Submission Open

Keywords: gynecologic pathology; breast pathology; placental pathology; diagnostic pitfalls; differential diagnosis; molecular biology; immunohistochemistry; in situ hybridization

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Ultrasound Diagnosis and Guided Intervention of Musculoskeletal/Neuromuscular Pathology, Second Edition

edited by

Ke-Vin Chang

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8700 | Submission Open

Keywords: diagnosis; ultrasound; pain; muscle; tendon; nerve; rehabiltation

(This special issue belongs to the Section Medical Imaging and Theranostics)

Artificial Intelligence in Dermatology

edited by Choon Chiat Oh

submission deadline 31 Dec 2025 | 4 articles | Viewed by 8407 | Submission Open

Keywords: dermatology; artificial intelligence; deep learning; skin cancers; diagnostic imaging

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnostic Techniques in Obstetrics and Gynecology: Current Practices and Future Directions

edited by Giuseppina Porcaro

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7899 | Submission Open

Keywords: diagnosis; prognosis; obstetrics and gynecology markers; clinical practice and patient care

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Diagnosis and Management of Bone Diseases in 2025

edited by Hans-Christof Schober

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7788 | Submission Open

Keywords: osteoporosis; diagnostic; morphology; forces; muscle strength; therapy

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Echocardiography

edited by Grazia Canciello

submission deadline 31 Dec 2025 | 2 articles | Viewed by 7640 | Submission Open

Keywords: echocardiography; cardiovascular imaging; three-dimensional echocardiography; strain imaging; TrueVue imaging; cardiac function assessment; clinical applications; non-invasive cardiology; artificial intelligence

(This special issue belongs to the Section Medical Imaging and Theranostics)

Liquid Biopsy: Cancer Diagnostic Biomarkers of the Future

edited by

Dario Marchetti

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7491 | Submission Open

Keywords: liquid biopsy; circulating tumor cells (CTCs); ctDNA testing; exosomes; blood analytes

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Lung Cancer: Screening, Diagnosis and Management: 2nd Edition

edited by

Fu-Zong Wu

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7370 | Submission Open

Keywords: lung cancer; LDCT; overdiagnosis; artificial intelligence; deep learning; prognosis; radiomics; texture analysis; thoracic surgery

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Pathology and Diagnosis of Neurological Disorders, 2nd Edition

edited by James Yip

submission deadline 31 Dec 2025 | 2 articles | Viewed by 7081 | Submission Open

Keywords: stroke; CNS tumors; neurodegenerative diseases; traumatic brain injury

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Pathology and Diagnosis of Head and Neck Diseases

edited by

Eliano Cascardi

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6916 | Submission Open

Keywords: head and neck disease; histopathology; oral tumors; cancer; biomarkers; digital pathology; AI applications; personalized medicine

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Recent Advances in Sepsis

edited by

Zoran Todorovic

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6847 | Submission Open

Keywords: sepsis; biomarkers; diagnosis; personalized medicine

(This special issue belongs to the Section Clinical Laboratory Medicine)

Clinical Diagnosis and Management in Emergency and Hospital Medicine

edited by

Nin-Chieh Hsu

submission deadline 31 Dec 2025 | 6 articles | Viewed by 6791 | Submission Open

Keywords: diagnosis; treatment; management; hospital medicine; emergency medicine; point-of-care ultrasound; decision making; transitional care; palliative care; quality improvement

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Recent Advances in Epidemiological Diagnostics: Detecting and Controlling Infectious Diseases

edited by

Sri Banerjee

and W. Sumner Davis

submission deadline 31 Dec 2025 | 6 articles | Viewed by 6717 | Submission Open

Keywords: epidemiological diagnostics; disease control; clinical practice and patient care; public health; infectious diseases

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Recent Advances in Hearing and Audiology Science: Diagnosis and Management

edited by

Yu Sun

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5977 | Submission Open

Keywords: hearing loss; genetic deafness; cochlear implants; hair cell regeneration; central auditory processing; vestibular disorders; tinnitus intervention

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Clinical Impacts and Challenges in Capsule Endoscopy

edited by

Anastasios Koulaouzidis

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5675 | Submission Open

Keywords: capsule endoscopy; diagnostic endoscopy; small bowel evaluation; non-invasive exploration

(This special issue belongs to the Section Biomedical Optics)

Advances in Dental Diagnostics

edited by

Dirk Ziebolz

and Margherita Fontana

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5645 | Submission Open

Keywords: diagnosis; diagnostic imaging; artificial intelligence; caries; periodontitis; stomatognathic diseases

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Metabolic Diseases: Diagnosis, Management, and Pathogenesis

edited by Dee Pei

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5418 | Submission Open

Keywords: metabolic disease; obesity; aging; machine learning; pathophysiology; prevalence; ethnic differences

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis and Management of Musculoskeletal Disorders

edited by

Yuichi Yoshii

and

Takeshi Ogawa

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5271 | Submission Open

Keywords: musculoskeletal diseases; MRI; shoulder and elbow; Bone Necrosis; Wrist Arthroscopy

(This special issue belongs to the Section Medical Imaging and Theranostics)

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