Clinical Impacts and Challenges in Capsule Endoscopy

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Biomedical Optics".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 777

Special Issue Editor


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Guest Editor

Special Issue Information

Dear Colleagues,

I would like to invite you to contribute to an upcoming Special Issue titled "Clinical Impacts and Challenges in Capsule Endoscopy".

This Special Issue explores the evolving landscape of capsule endoscopy (CE) technology.

Since its inception, CE has significantly expanded the horizons of diagnostic endoscopy, particularly in small bowel evaluation. It has enabled the non-invasive exploration of the gastrointestinal tract, transforming our approach to diagnosing a range of conditions, from obscure GI bleeding to Crohn’s disease.

However, along with this progress come new hurdles—technical limitations, interpretative complexity, and real-world integration into everyday clinical practice remain pressing issues.

This Special Issue aims to provide a platform for clinicians, scientists and researchers to do the following:

  • Critically assess the clinical impact of capsule endoscopy on patient management and outcomes;
  • Share insights into technological advances that are pushing the boundaries of what capsule endoscopy can achieve;
  • Discuss limitations and persistent diagnostic blind spots, as well as ways to overcome them
  • Explore the current challenges faced in image interpretation and the practicalities of large-scale implementation in clinical workflows.

We welcome original research, insightful reviews, case reports, and expert perspectives that shed light on these aspects.

Your expertise could provide key contributions to the ongoing dialogue on how to refine and optimize this invaluable diagnostic tool further.

I encourage you to consider submitting your work and helping us shape the future of capsule endoscopy, an area that continues to challenge and inspire us all.

Prof. Dr. Anastasios Koulaouzidis
Guest Editor

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Keywords

  • capsule endoscopy
  • diagnostic endoscopy
  • small bowel evaluation
  • non-invasive exploration

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Published Papers (2 papers)

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Review

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11 pages, 1776 KiB  
Review
Unmet Needs of Artificial Intelligence in Small Bowel Capsule Endoscopy
by Stefania Piccirelli, Daniele Salvi, Cecilia Lina Pugliano, Enrico Tettoni, Antonio Facciorusso, Emanuele Rondonotti, Alessandro Mussetto, Lorenzo Fuccio, Paola Cesaro and Cristiano Spada
Diagnostics 2025, 15(9), 1092; https://doi.org/10.3390/diagnostics15091092 - 25 Apr 2025
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Abstract
Small bowel capsule endoscopy (SBCE) has emerged in the past two decades as the cornerstone for assessing small bowel disorders, and its use is supported by several guidelines. However, there are several limitations, such as the considerable time required for gastroenterologists to review [...] Read more.
Small bowel capsule endoscopy (SBCE) has emerged in the past two decades as the cornerstone for assessing small bowel disorders, and its use is supported by several guidelines. However, there are several limitations, such as the considerable time required for gastroenterologists to review these videos and reach a diagnosis. To address these limitations, researchers have explored the integration of artificial intelligence in the interpretation of these videos. In our review, we explore the evolving and emerging role of artificial intelligence in SBCE and examine the latest advancements and ongoing studies in these areas, aiming at overcoming current limitations. Full article
(This article belongs to the Special Issue Clinical Impacts and Challenges in Capsule Endoscopy)
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8 pages, 207 KiB  
Conference Report
The Future of Minimally Invasive GI and Capsule Diagnostics (REFLECT), October 2024
by Lea Østergaard Hansen, Alexandra Agache and Anastasios Koulaouzidis
Diagnostics 2025, 15(7), 859; https://doi.org/10.3390/diagnostics15070859 - 27 Mar 2025
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Abstract
The fifth annual REFLECT (The futuRE oF MinimalLy InvasivE GI and Capsule diagnosTics) symposium, held in October 2024 in Nyborg, Denmark, focused on advancements in minimally invasive gastrointestinal (GI) diagnostics, particularly capsule endoscopy (CE) technologies. Key discussions included clinical updates, innovations in hardware [...] Read more.
The fifth annual REFLECT (The futuRE oF MinimalLy InvasivE GI and Capsule diagnosTics) symposium, held in October 2024 in Nyborg, Denmark, focused on advancements in minimally invasive gastrointestinal (GI) diagnostics, particularly capsule endoscopy (CE) technologies. Key discussions included clinical updates, innovations in hardware and software, and the growing role of colon CE (CCE) in colorectal cancer screening. The event provided a platform for clinicians, engineers, industry representatives, and scientists to exchange knowledge and present the latest advancements in the field. Discussions covered clinical studies, future research protocols, and technological innovations, with also a notable focus on commercial solutions and expansion of the implementation of capsule endoscopy. The symposium also highlighted the significance of predictive models for patient selection and developments in panenteric CE. Innovative technologies presented included robotics for drug delivery and magnetic endoscopic guidance systems. AI advancements were discussed for their potential to reduce diagnostic fatigue and standardize image interpretation, but ethical concerns and the need for transparent algorithms remain. The importance of multidisciplinary collaboration was emphasized to bridge innovation and clinical practice. Home-based CCE delivery emerged as a promising model, despite mixed results from environmental impact assessments. Overall, REFLECT 2024 reinforced the clinical utility and challenges of capsule-based diagnostics, advocating for ongoing interdisciplinary research to support safe and effective integration into healthcare systems. Full article
(This article belongs to the Special Issue Clinical Impacts and Challenges in Capsule Endoscopy)
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