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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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AI‑Driven Innovations in Medical Imaging

edited by

Lulu Wang

submission deadline 30 Jan 2027 | 3 articles | Viewed by 1822 | Submission Open

Keywords: medical imaging; artificial intelligence; diagnostic imaging; deep learning; image analysis; clinical decision-making; precision medicine; translational research; trustworthy AI; human–AI collaboration

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Computational Approaches for Medical Diagnosis and Healthcare Settings

edited by

Chenkun Liaw

submission deadline 30 Jan 2027 | Viewed by 184 | Submission Open

Keywords: computer-aided diagnosis; computer-aided healthcare system; overly large healthcare computer system; innovation in health care algorithm

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Pathology and Diagnosis of Neurological Disorders, 2nd Edition

edited by James Yip

submission deadline 31 Jan 2027 | 4 articles | Viewed by 17253 | Submission Open

Keywords: stroke; CNS tumors; neurodegenerative diseases; traumatic brain injury

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Deep Learning in Biomedical Image and Signal Processing: Recent Advancements and Applications

edited by Narinder Singh Punn

submission deadline 31 Jan 2027 | 9 articles | Viewed by 14810 | Submission Open

Keywords: deep learning; biomedical image; signal processing; multimodal data fusion; explainable AI

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

New Insights into the Diagnosis of Pediatric Cholestasis

edited by Paola Francalanci

submission deadline 31 Jan 2027 | 4 articles | Viewed by 6715 | Submission Open

Keywords: extrahepatic cholestasis; intrahepatic cholestasis; biliary atresia; genetic liver disease; inborn errors of metabolism; jaundice; monogenic liver disease

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

AI-Driven Precision Medicine: Innovations in Diagnosis, Prognosis, and Management Response

edited by

Feng Gao

submission deadline 31 Jan 2027 | 6 articles | Viewed by 6610 | Submission Open

Keywords: precision medicine; artificial intelligence; clinical decision support; deep learning; large language models (LLMs); prognosis prediction; medical imaging

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Current Concepts in Fetal and Placental Pathology

edited by

Ovidiu Simion Cotoi

and

Diana-Maria Chiorean

submission deadline 31 Jan 2027 | 2 articles | Viewed by 6536 | Submission Open

Keywords: fetal pathology; placental pathology; perinatal outcomes; perinatal autopsy; maternal-fetal interface; intrauterine growth restriction; preeclampsia; stillbirth; villitis; chorioamnionitis; histopathology; molecular pathology; case reports

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Future Trends in Diagnostic and Interventional Radiology

edited by

Francesco Giurazza

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5519 | Submission Open

Keywords: diagnostic radiology; interventional radiology; medical imaging; artificial intelligence; minimally invasive therapy; radiomics; precision medicine; multidisciplinary research

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advanced Diagnosis and Integrated Management of Bone and Soft Tissue Tumors

edited by Tiao Lin

submission deadline 31 Jan 2027 | 6 articles | Viewed by 5435 | Submission Open

Keywords: musculoskeletal neoplasms; diagnostic imaging; molecular pathology; multidisciplinary treatment; personalized medicine; translational research; multidisciplinary collaboration

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Collaborative Robotics and Total Laboratory Automation in Clinical Diagnostics

edited by

Robert S. Ohgami

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4871 | Submission Open

Keywords: collaborative robotics; total laboratory automation (TLA); diagnostic medicine; clinical validation ; robotic liquid handling ; digital pathology ; clinical microbiology

(This special issue belongs to the Section Clinical Laboratory Medicine)

Advancements in Diagnosis of Colorectal Cancer

edited by

Piero Boraschi

submission deadline 31 Jan 2027 | 3 articles | Viewed by 4178 | Submission Open

Keywords: colorectal cancer; metastatic disease; colorectal liver metastases; chemotherapy; surgery; therapeutic response assessment; biomarkers; tumor regression grading; computed tomography; MRI; PET; intraoperative ultrasound; multidisciplinary management

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Beyond the Tipping Point: Advances in the Diagnosis and Management of Acute-on-Chronic Liver Failure and End-Stage Liver Disease

edited by Jonathan Soldera

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2942 | Submission Open

Keywords: liver cirrhosis; hepatorenal syndrome; acute-on-chronic liver failure; liver transplan-tation; biomarkers; diagnostic imaging; artificial intelligence; inflammation media-tors; prognosis; end-stage liver disease

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Novel Biomarkers for Clinical Diagnosis and Prognosis

edited by

Ji Hyun Park

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2827 | Submission Open

Keywords: biomarkers; personalized medicine; molecular signatures; prognosis predictive diagnostics; prognostic diagnostics; genetic biomarkers; blood analysis; liquid biopsy; tumor marker

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Applications of Machine Learning in Obstetrics and Gynecology

edited by Valentina Emilia Balas

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2110 | Submission Open

Keywords: machine learning; obstetrics and gynecology; pregnancy; pregnancy-related complications; reproductive medicine

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Lung Cancer: Screening, Diagnosis and Survival Outcomes

edited by

Nagashree Seetharamu

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1878 | Submission Open

Keywords: lung cancer; screening; diagnostic modalities; survival outcomes; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis of Corneal and Retinal Diseases

edited by

Cristina Nicula

and Alina Popa-Cherecheanu

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1798 | Submission Open

Keywords: imaging diagnosis; corneal diseases; retinal diseases; optical coherence tomography (OCT); ultrasound

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Current Status and Challenges of Heart Disease Diagnosis

edited by

Giuseppe Sgarito

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1792 | Submission Open

Keywords: heart disease; cardiovascular diagnosis; cardiac imaging; artificial intelligence; biomarkers; end-stage heart failure; electrophysiology; sudden cardiac death; tissue characterization; personalized medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Disease Prediction—2nd Edition

edited by

Chi-Chang Chang

and Chalong Cheewakriangkrai

submission deadline 31 Jan 2027 | 3 articles | Viewed by 1782 | Submission Open

Keywords: early diagnostics; medical big data analytics; intelligent diagnostic models in public health; survival analysis and health hazard evaluations; machine learning and generative intelligence; intelligent digital twins; automated/intelligent laboratory recommendation systems

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Diagnosis and Management of Liver Tumors

edited by

Marija Radmilović-Radjenović

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1447 | Submission Open

Keywords: liver tumors; hepatocellular carcinoma; immunotherapy; imaging; oncology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Brain Radiation Necrosis: Emerging Insights in Pathophysiology, Diagnosis, and Management

edited by

Nam P. Nguyen

and Gokoulakrichenane Loganadane

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1168 | Submission Open

Keywords: brain radiation necrosis; radiation therapy; multimodal imaging; differential diagnosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Ultrasound and Multimodal Diagnostics in Personalized Medicine

edited by

Ştefan Cristian Vesa

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1143 | Submission Open

Keywords: ultrasound; imaging; diagnostics; elastography; contrast-enhanced ultrasound; multimodal imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Sudden Unexpected Death in Infancy: Advances in Diagnostics and Multidisciplinary Investigation

edited by Maria P. Bonasoni

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1040 | Submission Open

Keywords: sudden unexpected death in infancy (SUDI); sudden infant death syndrome (SIDS); post‑mortem diagnostics; multidisciplinary investigation; medicolegal assessment

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Management of Contemporary Issues in Maternal-Fetal Medicine, 2nd Edition

edited by

Ioannis Tsakiridis

submission deadline 31 Jan 2027 | 1 articles | Viewed by 972 | Submission Open

Keywords: maternal-fetal medicine; high-risk pregnancy; pregnancy outcome; pregnancy complications

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Lung Cancer Diagnosis and Prognosis Prediction

edited by

Jieke Liu

and

Zhigang Chu

submission deadline 31 Jan 2027 | 1 articles | Viewed by 888 | Submission Open

Keywords: lung cancer; CT; artificial intelligence; deep learning; radiomics; habitat imaging; early detection; precision diagnosis; risk stratification; treatment response; prognosis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Precision Diagnostics in Lung and Respiratory Diseases

edited by

Evgeni Gershman

submission deadline 31 Jan 2027 | 1 articles | Viewed by 779 | Submission Open

Keywords: obstructive airway disease; interstitial lung disease; molecular diagnosis; thoracic imaging; biopsy of lung lesion

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Molecular Mechanisms in Ophthalmology

edited by Deepshikha Tewari

submission deadline 31 Jan 2027 | Viewed by 526 | Submission Open

Keywords: ophthalmology; molecular mechanisms; cellular processes; pathophysiology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Laboratory Diagnosis: Biomarker Validation and Diagnostic Performance

edited by

Ivana Lapić

submission deadline 31 Jan 2027 | Viewed by 511 | Submission Open

Keywords: biomarkers; validation; diagnostic accuracy; clinical performance; patient safety

(This special issue belongs to the Section Clinical Laboratory Medicine)

Diagnosis and Management of Pancreatic Cancer, Second Edition

edited by Nikolaos A. Chatzizacharias and Sarah F. Powell-Brett

submission deadline 31 Jan 2027 | 1 articles | Viewed by 509 | Submission Open

Keywords: pancreatic cancer; genetic sequencing; diagnosis; circulating tumour cells; imaging; neoadjuvant treatment; personalised systemic treatment; survival; recurrence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Oral and Maxillofacial Tumors and Salivary Gland Diseases

edited by

Maria Cristofaro

submission deadline 31 Jan 2027 | 1 articles | Viewed by 421 | Submission Open

Keywords: salivary gland tumors; oral squamous cell carcinoma; maxillofacial surgery; intraoperative nerve monitoring; prognostic biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Innovations in Tuberculosis Diagnostics

edited by

Kanagavel Murugesan

submission deadline 31 Jan 2027 | Viewed by 406 | Submission Open

Keywords: whole genome sequencing (WGS); targeted NGS; computer-aided detection (CAD); digital radiography; exosomes; volatile organic compounds; loop-mediated isothermal amplification (LAMP); NAAT; transcriptomics; proteomics; lateral flow assays

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Advances in Imaging‑Guided Oral and Maxillofacial Diagnosis

edited by Aleksa Janović

submission deadline 31 Jan 2027 | Viewed by 402 | Submission Open

Keywords: cone-beam computed tomography; dental MRI; ultrasound; computed tomography; image-based 3D modeling; artificial intelligence; digital image analysis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Breakthroughs in Advanced Medical X-Ray and CT Imaging: From Technology to Clinical Application

edited by Joyoni Dey

submission deadline 31 Jan 2027 | Viewed by 364 | Submission Open

Keywords: advanced X-ray CT imaging; X-ray CT interferometry; phase-contrast X-ray; photon-counting detectors

(This special issue belongs to the Section Medical Imaging and Theranostics)

Imaging in Heart Failure: Advances, Applications, and Future Directions

edited by

Attila Frigy

submission deadline 31 Jan 2027 | Viewed by 325 | Submission Open

Keywords: heart failure; echocardiography; cardiovascular magnetic resonance (CMR); computed tomography (CT); nuclear imaging (PET/SPECT); prognosis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advanced Meta-Analytical Approaches and Novel Diagnostic Technologies in Cardiovascular Medicine

edited by

Raheel Ahmed

submission deadline 31 Jan 2027 | Viewed by 317 | Submission Open

Keywords: meta-analysis; evidence synthesis; cardiovascular diagnosis; clinical evidence; evidence-based medicine; diagnostic accuracy; systematic review

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Biomarkers and Biodiagnostics in Neurodegenerative Diseases

edited by

Ludmilla Morozova-Roche

submission deadline 31 Jan 2027 | 1 articles | Viewed by 307 | Submission Open

Keywords: neurodegenerative diseases; biomarkers; biodiagnostics; protein misfolding

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Cardiovascular Diseases: Diagnosis and Management, Second Edition

edited by Hezzy Shmueli

submission deadline 31 Jan 2027 | Viewed by 287 | Submission Open

Keywords: real-time imaging; cardiovascular disease; cardiovascular imaging; echocardiography; cardiac CT; cardiac MRI; cardiac nuclear scan; acute cardiac care; artificial intelligence; cardiomyopathy

(This special issue belongs to the Section Medical Imaging and Theranostics)

Updated in Endocrine Pathology: From New Diagnosis Tools to Cross-Disciplinary Teams

edited by

Mara Carsote

submission deadline 31 Jan 2027 | Viewed by 282 | Submission Open

Keywords: adrenal; adrenalectomy; thyroid; thyroid cancer; thyroidectomy; pituitary gland; prolactin; hormone; endocrine; dynamic testing; biomarker; computer tomography; magnetic resonance imaging; scintigraphy; DXA; osteoporosis; bone; muscle

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Kidney Disease: Biomarkers, Diagnosis, and Prognosis—4th Edition

edited by

Akito Maeshima

submission deadline 31 Jan 2027 | 1 articles | Viewed by 256 | Submission Open

Keywords: primary/secondary glomerulonephritis; rapidly progressive glomerulonephritis; nephrotic syndrome; acute kidney injury; chronic kidney disease; diabetic nephropathy/diabetic kidney disease; chronic renal failure; kidney transplantation; renal fibrosis; polycystic kidney

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

AI and Explainable Intelligence for Medical Diagnosis: Emerging Trends and Future Directions

edited by

Olamilekan Shobayo

submission deadline 31 Jan 2027 | Viewed by 211 | Submission Open

Keywords: artificial intelligence; deep learning; vision transformers (ViTs); generative AI (GANs, VAEs, diffusion models); multimodal learning; radiology AI; image segmentation and classification; explainable AI (XAI); clinical decision support; medical image analysis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Machine Learning for Computer-Aided Diagnosis in Biomedical Imaging—3rd Edition

edited by

Farhan Akram

submission deadline 31 Jan 2027 | Viewed by 203 | Submission Open

Keywords: cancer diagnosis; medical images; electronic health records; machine learning; deep learning; artificial intelligence; explainable AI models; multi-modal analysis; federated learning; CAD systems

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

AI-Driven Diagnosis and Management in Otolaryngology

edited by

Zhiyu Wan

, Hui Yang and

Yike Li

submission deadline 22 Feb 2027 | Viewed by 67 | Submission Open

Keywords: artificial intelligence; otolaryngology; precision medicine; human voice; multimodal data; digital biomarkers; medical imaging; physiologic signal analysis; clinical decision support; translational medicine; responsible AI

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnosis and Management of Adverse Drug Reactions in Precision Medicine and Big Data

edited by

Elena Ramírez

submission deadline 28 Feb 2027 | 2 articles | Viewed by 18612 | Submission Open

Keywords: adverse drug reactions; pharmacovigilance; drug safety; risk factors; causality assessment; big data; precision medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Ultrasound Diagnosis and Guided Intervention of Musculoskeletal/Neuromuscular Pathology, Second Edition

edited by

Ke-Vin Chang

submission deadline 28 Feb 2027 | 7 articles | Viewed by 17842 | Submission Open

Keywords: diagnosis; ultrasound; pain; muscle; tendon; nerve; rehabiltation

(This special issue belongs to the Section Medical Imaging and Theranostics)

Artificial Intelligence in Diagnosis and Management of Cardiovascular Diseases

edited by

Corina Maria Vasile

and Xavier Iriart

submission deadline 28 Feb 2027 | 5 articles | Viewed by 8113 | Submission Open

Keywords: cardiovascular diseases; artificial intelligence; deep learning; machine learning; wearable devices; imaging techniques; personalized medicine; risk prediction; telemedicine; remote monitoring; ethical considerations

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advanced Role of Endoscopic Ultrasound in Clinical Medicine

edited by

Germana De Nucci

submission deadline 28 Feb 2027 | 3 articles | Viewed by 7716 | Submission Open

Keywords: endoscopic ultrasound (EUS); diagnostic imaging; fine needle aspiration (FNA); contrast-enhanced EUS; elastography techniques

(This special issue belongs to the Section Medical Imaging and Theranostics)

Application of Ultrasound Imaging in Clinical Diagnosis

edited by

Jinbum Kang

submission deadline 28 Feb 2027 | 6 articles | Viewed by 7021 | Submission Open

Keywords: diagnostic ultrasound imaging and systems; doppler ultrasound techniques and applications; elastography for tissue characterization; contrast-enhanced ultrasound (CEUS); artificial intelligence in diagnostic ultrasound; point-of-care ultrasound (POCUS); ultrasound-guided interventions

(This special issue belongs to the Section Medical Imaging and Theranostics)

Clinical Anatomy and Diagnosis of Peripheral Nervous System—2nd Edition

edited by

Alexandra Diana Vrapciu

submission deadline 28 Feb 2027 | 2 articles | Viewed by 5852 | Submission Open

Keywords: anatomy; peripheral nervous system; imaging

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Artificial Intelligence in Alzheimer’s Disease Diagnosis—2nd Edition

edited by

Mohammad Shahadat Hossain

submission deadline 28 Feb 2027 | 6 articles | Viewed by 5560 | Submission Open

Keywords: Alzheimer’s disease; artificial intelligence; machine learning; explainable AI; expert systems; computer vision; deep learning; diagnosis; cognition; brain informatics; neurodegenerative disorder

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Endoscopy in Gynecology and Gynecologic Oncology

edited by

Rudolf Lampé

submission deadline 28 Feb 2027 | 1 articles | Viewed by 4660 | Submission Open

Keywords: gynecology; endoscopy; operative gynecology

(This special issue belongs to the Section Medical Imaging and Theranostics)

Fetal Doppler Assessment: From Basic Research to Clinical Practice

edited by Luís Guedes-Martins

submission deadline 28 Feb 2027 | 1 articles | Viewed by 4054 | Submission Open

Keywords: fetal Doppler; fetal growth restriction; preeclampsia; fetal-placental hemodynamics; fetal death; placental abruption; placental circulation; fetal cerebral circulation; fetal hepatic circulation; fetal heart function

(This special issue belongs to the Section Medical Imaging and Theranostics)

Displaying special issue 451-500 on page 10 of 13.

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