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Diagnostics
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Advanced Diagnosis and Integrated Management of Bone and Soft Tissue...
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Advanced Diagnosis and Integrated Management of Bone and Soft Tissue Tumors

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 989

Special Issue Editor

Dr. Tiao Lin

E-Mail Website
Guest Editor
1. Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
2. Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Interests: musculoskeletal neoplasms; diagnostic imaging; molecular pathology

Special Issue Information

Dear Colleagues,

This Special Issue will showcase cutting-edge research and clinical insights in the multidisciplinary field of bone and soft tissue tumor diagnosis and management, covering both benign and malignant tumors, such as osteosarcoma, chondrosarcoma, Ewing’s sarcoma, and liposarcoma. The main focus areas will include 1) novel diagnostic techniques, such as advanced imaging, molecular/genomic profiling, and AI-assisted pathological diagnosis; 2) unique case reports highlighting rare cases, diagnostic challenges, or innovative treatment approaches; and 3) translational research linking laboratory findings with clinical practice, prognostic markers, and personalized treatment strategies. We welcome original research, systematic reviews, clinical trials, and case studies, with an emphasis on multidisciplinary collaboration (orthopedic oncology, radiology, pathology, and medical oncology). This Special Issue will serve as a comprehensive resource for clinicians and researchers dedicated to improving the prognosis of patients with bone and soft tissue tumors. Additionally, we encourage submissions exploring the role of emerging technologies, such as liquid biopsy, circulating tumor cells, and single-cell sequencing, in the context of bone and soft tissue tumor diagnosis and management.

Dr. Tiao Lin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • musculoskeletal neoplasms
  • diagnostic imaging
  • molecular pathology
  • multidisciplinary treatment
  • personalized medicine
  • translational research
  • multidisciplinary collaboration

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Published Papers (2 papers)

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11 pages, 4202 KB  
Article
Pattern of Mandibular Bone Invasion as a Prognostic Factor
by Richard Pink, Jaroslav Michálek, Zdeněk Dvořák, Peter Tvrdý, Lenka Šašková, Michal Herman, Petr Heinz, Markéta Hermanová, Jana Zapletalová and Michal Mozoľa
Diagnostics 2025, 15(23), 2989; https://doi.org/10.3390/diagnostics15232989 - 25 Nov 2025
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Abstract
Background/Objectives: Mandibular bone invasion is a common and clinically relevant feature of OSCC, particularly in tumors of the lower alveolus, floor of mouth, and retromolar trigone. The prognostic value of the pattern of invasion—rather than its mere presence—remains insufficiently defined. Therefore, we evaluated [...] Read more.
Background/Objectives: Mandibular bone invasion is a common and clinically relevant feature of OSCC, particularly in tumors of the lower alveolus, floor of mouth, and retromolar trigone. The prognostic value of the pattern of invasion—rather than its mere presence—remains insufficiently defined. Therefore, we evaluated the prognostic relevance of erosive vs. infiltrative mandibular invasion and the diagnostic reliability of preoperative CT. Methods: This retrospective, single-center observational cohort study included 83 patients with OSCC involving or adjacent to the mandible who underwent surgical resection at the Department of Oral and Maxillofacial Surgery, University Hospital Olomouc (2008–2018). Bone invasion type was classified histopathologically as erosive or infiltrative. Survival outcomes were analyzed using Kaplan–Meier and Cox regression methods. Correlation between radiologic and histologic findings was assessed using Cohen’s kappa statistics. Results: Mandibular invasion was confirmed in 50.6% of cases, of which roughly two-thirds were infiltrative. DSS differed across invasion groups (log-rank p = 0.012): infiltrative had a median DSS of 14.5 months (95% CI 0.0–32.8), no invasion had 54.2 months (CI not estimable), while erosive did not reach the median (fewer than half experienced the event). In the adjusted model (covariates: invasion type, ENE, grade, margins), infiltrative vs. no invasion was associated with worse DSS (aHR 1.93, 95% CI 1.02–3.64; p = 0.042); for OS, erosive vs. no invasion showed a protective association (aHR 0.39, 95% CI 0.16–0.96; p = 0.041). Positive/close margins were independently adverse across endpoints (e.g., DSS aHR 3.30, 95% CI 1.74–6.22). CT–histology agreement for bone invasion was κ = 0.45, indicating moderate agreement. Conclusions: In this retrospective single-center cohort, the pattern of mandibular bone invasion was associated with survival: infiltrative invasion aligned with worse outcomes, whereas erosive behaved similarly to no invasion, particularly for OS. Prospective, multicenter validation is warranted before routine incorporation into risk stratification or treatment selection. Full article
(This article belongs to the Special Issue Advanced Diagnosis and Integrated Management of Bone and Soft Tissue Tumors)
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Perineurial Malignant Peripheral Nerve Sheath Tumor of the Cauda Equina: Diagnostic Challenge
by Tomonori Kawasaki, Tomoaki Torigoe, Takuya Watanabe, Satoshi Kanno, Masataka Hirasaki, Arisa Kokubo, Kojiro Onohara, Masanori Wako, Tetsuhiro Hagino and Jiro Ichikawa
Diagnostics 2025, 15(21), 2697; https://doi.org/10.3390/diagnostics15212697 - 24 Oct 2025
Viewed by 477
Abstract
Malignant peripheral nerve sheath tumors (MPNSTs) are rare sarcomas with an extremely rare perineurial subtype. Herein, we present a case of a perineurial MPNST in the cauda equina. Clinically and radiologically, a mass extending from within the spinal canal at the L5 level [...] Read more.
Malignant peripheral nerve sheath tumors (MPNSTs) are rare sarcomas with an extremely rare perineurial subtype. Herein, we present a case of a perineurial MPNST in the cauda equina. Clinically and radiologically, a mass extending from within the spinal canal at the L5 level to outside the intervertebral foramen was identified, raising suspicion of a neurogenic tumor as the primary diagnosis. Computed tomography-guided biopsy suggested an intermediate- to low-grade malignancy; however, a definitive diagnosis could not be established. Two years later, worsening neurological symptoms prompted further imaging, which revealed significant tumor growth and bone invasion. Open biopsy was performed to obtain a definitive diagnosis of perineurial MPNST. MPNSTs lack distinctive imaging features and are generally diagnosed based on a combination of radiological and histopathological findings. Although MPNSTs have a poor prognosis, the perineurial subtype is considered to have a relatively favorable outcome. Given these factors, early diagnosis followed by surgical resection or radiation therapy is recommended. Full article
(This article belongs to the Special Issue Advanced Diagnosis and Integrated Management of Bone and Soft Tissue Tumors)
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