Advanced Diagnosis and Integrated Management of Bone and Soft Tissue Tumors

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 412

Special Issue Editor


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Guest Editor
1. Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
2. Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Interests: musculoskeletal neoplasms; diagnostic imaging; molecular pathology

Special Issue Information

Dear Colleagues,

This Special Issue will showcase cutting-edge research and clinical insights in the multidisciplinary field of bone and soft tissue tumor diagnosis and management, covering both benign and malignant tumors, such as osteosarcoma, chondrosarcoma, Ewing’s sarcoma, and liposarcoma. The main focus areas will include 1) novel diagnostic techniques, such as advanced imaging, molecular/genomic profiling, and AI-assisted pathological diagnosis; 2) unique case reports highlighting rare cases, diagnostic challenges, or innovative treatment approaches; and 3) translational research linking laboratory findings with clinical practice, prognostic markers, and personalized treatment strategies. We welcome original research, systematic reviews, clinical trials, and case studies, with an emphasis on multidisciplinary collaboration (orthopedic oncology, radiology, pathology, and medical oncology). This Special Issue will serve as a comprehensive resource for clinicians and researchers dedicated to improving the prognosis of patients with bone and soft tissue tumors. Additionally, we encourage submissions exploring the role of emerging technologies, such as liquid biopsy, circulating tumor cells, and single-cell sequencing, in the context of bone and soft tissue tumor diagnosis and management.

Dr. Tiao Lin
Guest Editor

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Keywords

  • musculoskeletal neoplasms
  • diagnostic imaging
  • molecular pathology
  • multidisciplinary treatment
  • personalized medicine
  • translational research
  • multidisciplinary collaboration

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Published Papers (1 paper)

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6 pages, 2063 KB  
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Perineurial Malignant Peripheral Nerve Sheath Tumor of the Cauda Equina: Diagnostic Challenge
by Tomonori Kawasaki, Tomoaki Torigoe, Takuya Watanabe, Satoshi Kanno, Masataka Hirasaki, Arisa Kokubo, Kojiro Onohara, Masanori Wako, Tetsuhiro Hagino and Jiro Ichikawa
Diagnostics 2025, 15(21), 2697; https://doi.org/10.3390/diagnostics15212697 - 24 Oct 2025
Viewed by 309
Abstract
Malignant peripheral nerve sheath tumors (MPNSTs) are rare sarcomas with an extremely rare perineurial subtype. Herein, we present a case of a perineurial MPNST in the cauda equina. Clinically and radiologically, a mass extending from within the spinal canal at the L5 level [...] Read more.
Malignant peripheral nerve sheath tumors (MPNSTs) are rare sarcomas with an extremely rare perineurial subtype. Herein, we present a case of a perineurial MPNST in the cauda equina. Clinically and radiologically, a mass extending from within the spinal canal at the L5 level to outside the intervertebral foramen was identified, raising suspicion of a neurogenic tumor as the primary diagnosis. Computed tomography-guided biopsy suggested an intermediate- to low-grade malignancy; however, a definitive diagnosis could not be established. Two years later, worsening neurological symptoms prompted further imaging, which revealed significant tumor growth and bone invasion. Open biopsy was performed to obtain a definitive diagnosis of perineurial MPNST. MPNSTs lack distinctive imaging features and are generally diagnosed based on a combination of radiological and histopathological findings. Although MPNSTs have a poor prognosis, the perineurial subtype is considered to have a relatively favorable outcome. Given these factors, early diagnosis followed by surgical resection or radiation therapy is recommended. Full article
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