Current Status and Challenges of Heart Disease Diagnosis

Dear Colleagues,

Heart disease remains a leading cause of illness and death globally, underscoring the urgent need for ongoing improvements in diagnostic strategies. This Special Issue aims to examine the current status and evolving challenges in diagnosing heart disease, focusing on foundational knowledge and recent innovations. It highlights emerging tools and approaches that are transforming cardiovascular care.

This Special Issue aims to discuss novel biomarkers, advanced imaging techniques, and the integration of artificial intelligence to improve diagnostic accuracy. We also aim to examine subspecialty areas that are increasingly significant in modern cardiovascular care. For instance, end-stage heart failure presents diagnostic challenges due to overlapping comorbidities and nonspecific symptoms, requiring refined tools for timely referrals to advanced therapies, such as ventricular assistance devices or heart transplantation.

Innovations in cardiac imaging—including cardiac MRI, CT, and advanced echocardiographic techniques—are becoming essential for the early detection, risk stratification, and ongoing assessment of various cardiac conditions. In particular, quantitative imaging and tissue characterization enhance our ability to identify subclinical disease and inform clinical decision-making.

The field of cardiac electrophysiology is rapidly advancing, with a growing focus on the early identification of arrhythmic risk through ECG analysis, genetic testing, and electroanatomic mapping. These tools are crucial for preventing sudden cardiac death and customizing treatments for inherited and acquired arrhythmia syndromes.

By integrating technological innovation, clinical expertise, and translational research, this Special Issue aims to inspire meaningful advancements in the early and accurate diagnosis of cardiovascular disease. The goal is to develop personalized diagnostic pathways tailored to each patient’s risk profile and clinical context.

Dr. Giuseppe Sgarito
Guest Editor

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