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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Diagnostic and Prognostic Tools in Gynecological Cancer

edited by

Ahmad Sayasneh

submission deadline 31 Dec 2026 | Viewed by 446 | Submission Open

Keywords: gynaecological cancer; diagnostic imaging; artificial intelligence; molecular biomarkers; prognostic models; surgical navigation; precision oncology; translational research

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Pathogenesis, Diagnosis, and Management of Rheumatic Disease: Progress and Challenges

edited by Miguel Ángel González-Gay

submission deadline 31 Dec 2026 | Viewed by 444 | Submission Open

Keywords: rheumatic disease; systemic vasculitis; rheumatoid arthritis; metabolic syndrome; atherosclerosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Selected Papers From the 1st International Online Conference on Diagnostics [IOCDi 2026]

edited by

Giorgio Treglia

submission deadline 31 Dec 2026 | Viewed by 405 | Submission Open

Keywords: imaging diagnosis; pathology diagnosis; molecular diagnosis; clinical diagnosis; laboratory medicine; point-of-care diagnosis; artificial intelligence

Machine Learning in Disease Diagnosis

edited by

Chi-Jie Lu

and

Yi-Wei Kao

submission deadline 31 Dec 2026 | Viewed by 388 | Submission Open

Keywords: machine learning; disease diagnosis; medical/healthcare informatics; multimodal learning; explainable AI (XAI); federated learning; clinical decision support

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Data Science and Artificial Intelligence in Laboratory Medicine

edited by

Fernando Marques-Garcia

submission deadline 31 Dec 2026 | Viewed by 352 | Submission Open

Keywords: artificial intelligence; data science; algorithm; laboratory medicine

(This special issue belongs to the Section Clinical Laboratory Medicine)

Liquid Biopsy and Molecular Diagnostics in Neuro-Oncology

edited by Santiago Cabezas-Camarero and Juan Manuel Sepúlveda-Sánchez

submission deadline 31 Dec 2026 | Viewed by 344 | Submission Open

Keywords: liquid biopsy; biofluids; biomarkers; molecular techniques; gliomas; neuro-oncology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Endoscopic Diagnosis and Management of Tumors

edited by

Longjun He

submission deadline 31 Dec 2026 | Viewed by 326 | Submission Open

Keywords: endoscopy; tumor diagnosis; endoscopic therapy; endoscopic ultrasound; artificial intelligence; early cancer detection; minimally invasive surgery; precision oncology; molecular imaging; translational research

(This special issue belongs to the Section Biomedical Optics)

Precision Diagnostics in Renal Transplantation and Transplant Complications

edited by

Cheng Yang

submission deadline 31 Dec 2026 | Viewed by 304 | Submission Open

Keywords: renal transplantation; precision diagnostics; allograft rejection; non-invasive monitoring; biomarkers; multi-omics; kidney transplant complications; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Precision Diagnosis in Musculoskeletal Disorders: Current and Future Directions

edited by

Yuichi Yoshii

submission deadline 31 Dec 2026 | Viewed by 276 | Submission Open

Keywords: precision diagnosis; musculoskeletal imaging; artificial intelligence; quantitative imaging biomarkers; automated morphological analysis; predictive modeling; 3D patient-specific modeling; digital twin; image-guided diagnosis; personalized musculoskeletal care

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

New Perspectives in the Diagnosis of Gastroenterological Diseases

edited by Reena Sidhu

submission deadline 31 Dec 2026 | Viewed by 249 | Submission Open

Keywords: small bowel; bleeding; Crohn’s disease; endoscopy; coeliac disease; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Diagnosis, Prognosis, and Management of Urinary Disease—2nd Edition

edited by

Nicola Longo

and

Massimiliano Creta

submission deadline 31 Dec 2026 | Viewed by 248 | Submission Open

Keywords: urinary disease; diagnosis; prognosis; kidney disease; prostate disease; malignant diseases like kidney cancer, bladder cancer and prostate cancer

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Point-of-Care and At-Home Diagnostics for Infectious Diseases

edited by Gregory J. Tobin and Ke Du

submission deadline 31 Dec 2026 | Viewed by 238 | Submission Open

Keywords: infectious agents; at-home diagnostic; point-of-care diagnostic; pathogen surveillance; digital health; novel detection technologies; low-resource settings

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Advances in Diagnosis and Treatment of Thyroid Cancer

edited by

Chang Myeon Song

submission deadline 31 Dec 2026 | Viewed by 204 | Submission Open

Keywords: thyroid cancer; diagnosis; robotic thyroid surgery; thyroidectomy; molecular diagnostics; minimally invasive surgery; risk stratification; precision medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Early Diagnosis and Imaging-Guided Management of Oral Diseases: Advances and Perspectives

edited by

Matthieu Renaud

submission deadline 31 Dec 2026 | Viewed by 201 | Submission Open

Keywords: early diagnosis; oral diseases; medical imaging; artificial intelligence; biomarkers; multimodal diagnosis; inflammation; tissue monitoring

(This special issue belongs to the Section Medical Imaging and Theranostics)

Lung Monitoring in Critical Care

edited by Lorenzo Ball

submission deadline 31 Dec 2026 | Viewed by 201 | Submission Open

Keywords: lung monitoring; critical care; mechanical ventilation; diagnosis; imaging

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Innovative Diagnostic Strategies for Inherited Metabolic Diseases

edited by Radha Ramachandran

submission deadline 31 Dec 2026 | Viewed by 188 | Submission Open

Keywords: inherited metabolic; diagnostic; prognostic monitoring; personalised genetic functional omics

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

AI‑Driven Innovations in Medical Imaging

edited by

Lulu Wang

submission deadline 30 Jan 2027 | 3 articles | Viewed by 2626 | Submission Open

Keywords: medical imaging; artificial intelligence; diagnostic imaging; deep learning; image analysis; clinical decision-making; precision medicine; translational research; trustworthy AI; human–AI collaboration

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Computational Approaches for Medical Diagnosis and Healthcare Settings

edited by

Chenkun Liaw

submission deadline 30 Jan 2027 | Viewed by 253 | Submission Open

Keywords: computer-aided diagnosis; computer-aided healthcare system; overly large healthcare computer system; innovation in health care algorithm

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Pathology and Diagnosis of Neurological Disorders, 2nd Edition

edited by James Yip

submission deadline 31 Jan 2027 | 4 articles | Viewed by 18920 | Submission Open

Keywords: stroke; CNS tumors; neurodegenerative diseases; traumatic brain injury

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Deep Learning in Biomedical Image and Signal Processing: Recent Advancements and Applications

edited by Narinder Singh Punn

submission deadline 31 Jan 2027 | 9 articles | Viewed by 16129 | Submission Open

Keywords: deep learning; biomedical image; signal processing; multimodal data fusion; explainable AI

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

New Insights into the Diagnosis of Pediatric Cholestasis

edited by Paola Francalanci

submission deadline 31 Jan 2027 | 4 articles | Viewed by 8101 | Submission Open

Keywords: extrahepatic cholestasis; intrahepatic cholestasis; biliary atresia; genetic liver disease; inborn errors of metabolism; jaundice; monogenic liver disease

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

AI-Driven Precision Medicine: Innovations in Diagnosis, Prognosis, and Management Response

edited by

Feng Gao

submission deadline 31 Jan 2027 | 7 articles | Viewed by 8077 | Submission Open

Keywords: precision medicine; artificial intelligence; clinical decision support; deep learning; large language models (LLMs); prognosis prediction; medical imaging

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Current Concepts in Fetal and Placental Pathology

edited by

Ovidiu Simion Cotoi

and

Diana-Maria Chiorean

submission deadline 31 Jan 2027 | 2 articles | Viewed by 7257 | Submission Open

Keywords: fetal pathology; placental pathology; perinatal outcomes; perinatal autopsy; maternal-fetal interface; intrauterine growth restriction; preeclampsia; stillbirth; villitis; chorioamnionitis; histopathology; molecular pathology; case reports

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advanced Diagnosis and Integrated Management of Bone and Soft Tissue Tumors

edited by Tiao Lin

submission deadline 31 Jan 2027 | 6 articles | Viewed by 6259 | Submission Open

Keywords: musculoskeletal neoplasms; diagnostic imaging; molecular pathology; multidisciplinary treatment; personalized medicine; translational research; multidisciplinary collaboration

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Future Trends in Diagnostic and Interventional Radiology

edited by

Francesco Giurazza

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5908 | Submission Open

Keywords: diagnostic radiology; interventional radiology; medical imaging; artificial intelligence; minimally invasive therapy; radiomics; precision medicine; multidisciplinary research

(This special issue belongs to the Section Medical Imaging and Theranostics)

Collaborative Robotics and Total Laboratory Automation in Clinical Diagnostics

edited by

Robert S. Ohgami

submission deadline 31 Jan 2027 | 2 articles | Viewed by 5658 | Submission Open

Keywords: collaborative robotics; total laboratory automation (TLA); diagnostic medicine; clinical validation ; robotic liquid handling ; digital pathology ; clinical microbiology

(This special issue belongs to the Section Clinical Laboratory Medicine)

Current Diagnosis and Management of Oral Cancer: Challenges, Advances, and Multidisciplinary Integration

edited by Eleni A. Georgakopoulou

submission deadline 31 Jan 2027 | 6 articles | Viewed by 4761 | Submission Open

Keywords: oral cancer; early diagnosis; oral squamous cell carcinoma; artificial intelligence; oral potentially malignant disorders; multidisciplinary management; tumor board; oral pathology; misinformation; dental screening

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advancements in Diagnosis of Colorectal Cancer

edited by

Piero Boraschi

submission deadline 31 Jan 2027 | 3 articles | Viewed by 4605 | Submission Open

Keywords: colorectal cancer; metastatic disease; colorectal liver metastases; chemotherapy; surgery; therapeutic response assessment; biomarkers; tumor regression grading; computed tomography; MRI; PET; intraoperative ultrasound; multidisciplinary management

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Beyond the Tipping Point: Advances in the Diagnosis and Management of Acute-on-Chronic Liver Failure and End-Stage Liver Disease

edited by Jonathan Soldera

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3638 | Submission Open

Keywords: liver cirrhosis; hepatorenal syndrome; acute-on-chronic liver failure; liver transplan-tation; biomarkers; diagnostic imaging; artificial intelligence; inflammation media-tors; prognosis; end-stage liver disease

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Novel Biomarkers for Clinical Diagnosis and Prognosis

edited by

Ji Hyun Park

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3452 | Submission Open

Keywords: biomarkers; personalized medicine; molecular signatures; prognosis predictive diagnostics; prognostic diagnostics; genetic biomarkers; blood analysis; liquid biopsy; tumor marker

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Applications of Machine Learning in Obstetrics and Gynecology

edited by Valentina Emilia Balas

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2300 | Submission Open

Keywords: machine learning; obstetrics and gynecology; pregnancy; pregnancy-related complications; reproductive medicine

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Disease Prediction—2nd Edition

edited by

Chi-Chang Chang

and Chalong Cheewakriangkrai

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2242 | Submission Open

Keywords: early diagnostics; medical big data analytics; intelligent diagnostic models in public health; survival analysis and health hazard evaluations; machine learning and generative intelligence; intelligent digital twins; automated/intelligent laboratory recommendation systems

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Lung Cancer: Screening, Diagnosis and Survival Outcomes

edited by

Nagashree Seetharamu

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2176 | Submission Open

Keywords: lung cancer; screening; diagnostic modalities; survival outcomes; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis of Corneal and Retinal Diseases

edited by

Cristina Nicula

and Alina Popa-Cherecheanu

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2158 | Submission Open

Keywords: imaging diagnosis; corneal diseases; retinal diseases; optical coherence tomography (OCT); ultrasound

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Current Status and Challenges of Heart Disease Diagnosis

edited by

Giuseppe Sgarito

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2008 | Submission Open

Keywords: heart disease; cardiovascular diagnosis; cardiac imaging; artificial intelligence; biomarkers; end-stage heart failure; electrophysiology; sudden cardiac death; tissue characterization; personalized medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Laboratory Diagnosis: Biomarker Validation and Diagnostic Performance

edited by

Ivana Lapić

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1906 | Submission Open

Keywords: biomarkers; validation; diagnostic accuracy; clinical performance; patient safety

(This special issue belongs to the Section Clinical Laboratory Medicine)

Lung Cancer Diagnosis and Prognosis Prediction

edited by

Jieke Liu

and

Zhigang Chu

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1886 | Submission Open

Keywords: lung cancer; CT; artificial intelligence; deep learning; radiomics; habitat imaging; early detection; precision diagnosis; risk stratification; treatment response; prognosis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Diagnosis and Management of Liver Tumors

edited by

Marija Radmilović-Radjenović

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1686 | Submission Open

Keywords: liver tumors; hepatocellular carcinoma; immunotherapy; imaging; oncology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Ultrasound and Multimodal Diagnostics in Personalized Medicine

edited by

Ştefan Cristian Vesa

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1392 | Submission Open

Keywords: ultrasound; imaging; diagnostics; elastography; contrast-enhanced ultrasound; multimodal imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnosis and Management of Contemporary Issues in Maternal-Fetal Medicine, 2nd Edition

edited by

Ioannis Tsakiridis

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1381 | Submission Open

Keywords: maternal-fetal medicine; high-risk pregnancy; pregnancy outcome; pregnancy complications

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Brain Radiation Necrosis: Emerging Insights in Pathophysiology, Diagnosis, and Management

edited by

Nam P. Nguyen

and Gokoulakrichenane Loganadane

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1346 | Submission Open

Keywords: brain radiation necrosis; radiation therapy; multimodal imaging; differential diagnosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Sudden Unexpected Death in Infancy: Advances in Diagnostics and Multidisciplinary Investigation

edited by Maria P. Bonasoni

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1305 | Submission Open

Keywords: sudden unexpected death in infancy (SUDI); sudden infant death syndrome (SIDS); post‑mortem diagnostics; multidisciplinary investigation; medicolegal assessment

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Management of Pancreatic Cancer, Second Edition

edited by Nikolaos A. Chatzizacharias and Sarah F. Powell-Brett

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1086 | Submission Open

Keywords: pancreatic cancer; genetic sequencing; diagnosis; circulating tumour cells; imaging; neoadjuvant treatment; personalised systemic treatment; survival; recurrence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Imaging‑Guided Oral and Maxillofacial Diagnosis

edited by Aleksa Janović

submission deadline 31 Jan 2027 | Viewed by 1072 | Submission Open

Keywords: cone-beam computed tomography; dental MRI; ultrasound; computed tomography; image-based 3D modeling; artificial intelligence; digital image analysis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Precision Diagnostics in Lung and Respiratory Diseases

edited by

Evgeni Gershman

submission deadline 31 Jan 2027 | 1 articles | Viewed by 947 | Submission Open

Keywords: obstructive airway disease; interstitial lung disease; molecular diagnosis; thoracic imaging; biopsy of lung lesion

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Kidney Disease: Biomarkers, Diagnosis, and Prognosis—4th Edition

edited by

Akito Maeshima

submission deadline 31 Jan 2027 | 1 articles | Viewed by 849 | Submission Open

Keywords: primary/secondary glomerulonephritis; rapidly progressive glomerulonephritis; nephrotic syndrome; acute kidney injury; chronic kidney disease; diabetic nephropathy/diabetic kidney disease; chronic renal failure; kidney transplantation; renal fibrosis; polycystic kidney

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Innovations in Tuberculosis Diagnostics

edited by

Kanagavel Murugesan

submission deadline 31 Jan 2027 | 1 articles | Viewed by 760 | Submission Open

Keywords: whole genome sequencing (WGS); targeted NGS; computer-aided detection (CAD); digital radiography; exosomes; volatile organic compounds; loop-mediated isothermal amplification (LAMP); NAAT; transcriptomics; proteomics; lateral flow assays

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Advances in Oral and Maxillofacial Tumors and Salivary Gland Diseases

edited by

Maria Cristofaro

submission deadline 31 Jan 2027 | 1 articles | Viewed by 605 | Submission Open

Keywords: salivary gland tumors; oral squamous cell carcinoma; maxillofacial surgery; intraoperative nerve monitoring; prognostic biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Molecular Mechanisms in Ophthalmology

edited by Deepshikha Tewari

submission deadline 31 Jan 2027 | Viewed by 549 | Submission Open

Keywords: ophthalmology; molecular mechanisms; cellular processes; pathophysiology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

AI and Explainable Intelligence for Medical Diagnosis: Emerging Trends and Future Directions

edited by

Olamilekan Shobayo

submission deadline 31 Jan 2027 | 1 articles | Viewed by 547 | Submission Open

Keywords: artificial intelligence; deep learning; vision transformers (ViTs); generative AI (GANs, VAEs, diffusion models); multimodal learning; radiology AI; image segmentation and classification; explainable AI (XAI); clinical decision support; medical image analysis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

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