Innate Immunity and Genetics of Liver Diseases

Dear Colleagues,

Research on innate immunity is rapidly evolving and the impact of various immune cells and molecular pathways on the development and progression of chronic liver diseases is currently being investigated. The innate immune system represents the first line of defense against bacterial and viral infections in the liver but also contributes to inflammatory processes. Hepatic inflammation triggers the development of chronic liver diseases and is the main driver of fibrogenesis and hepatocarcinogenesis. Host genetic factors can also affect hepatic signaling components of the innate immune system, leading to an imbalance in immune responses. Gaining a better understanding of the mechanisms by which cellular responses, signaling pathways and genetic variants affect the pathophysiology of liver diseases and cause liver injury is of great importance. Targeting innate immune meachisms represents a promising tool for the diagnosis of liver diseases and new treatment approaches in personalized medicine.

We welcome submissions on the following topics:

• Identification and characterization of genetic variants;
• Investigations into the functional relevance of genetic variations and simulations of the in vivo effects of possible response genes in cell culture, especially in the context of clinically relevant liver diseases;
• Investigations into either the complete signaling pathway of the innate immune responses or its individual components;
• New therapeutic strategies targeting innate immunity. 

Dr. Janett Fischer
Guest Editor

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