Special Issue "The Diagnostic Value of Cerebrospinal Fluid"
Deadline for manuscript submissions: closed (31 December 2021).
Interests: neurodegenerative disease; biomarker discovery; CSF and plasma analysis; proteomics; mass spectrometry
Cerebrospinal fluid (CSF) is in direct contact with the brain and extends into the spinal cord. The main functions of CSF are to provide physical stability for the central nervous system (CNS), to actively regulate the CNS by supplying hormones and neuropeptides to it, and to remove various CNS metabolites. Due to its direct contact with the CNS, CSF is of great diagnostic importance. Thus, it can serve as a representative for the state of health of the CNS and provide important information on neurological diseases and disorders, which include for instance dementias (e.g. Alzheimer disease and Parkinson's disease), cerebrovascular diseases (e.g. stroke), neurotraum (e.g. spinal cord injury and traumatic brain injury), multiple sclerosis, neuroinfections and brain tumors. The early detection of neurological diseases as well as tools to assess the severity of destruction or predicting recovery is of utmost importance for optimal treatment. Biomarkers such as metabolites, lipids and proteins are suitable for such detections, which can be used as an indicator for biological and pathological processes but also for pharmacological responses to a therapeutic intervention. For a large number of neurological diseases such as meningitis or multiple sclerosis, the examination of CSF is already used for diagnosis and therapy decisions. For other neurological diseases and disorders, however, there is still a lack of diagnostic approaches and therefore there is a great interest in CSF in a scientific context.
In this Special Issue, we welcome contributions that provide an update on a wide range of topics in CSF diagnostics (e.g. milestones in CSF analysis or the current diagnostic standards). However, this issue also focuses on new and innovative approaches that are important for CSF-based diagnostics.
Dr. Katalin Barkovits
Prof. Dr. Katrin Marcus
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cerebrospinal fluid (CSF)
- neurological diseases and disorders
- central nervous system (CNS)
- multiple sclerosis
- brain tumors