Application of Neuroimaging Biomarkers in the Diagnosis and Treatment of Mental Diseases, 2nd Edition
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".
Deadline for manuscript submissions: 25 August 2025 | Viewed by 3421
Special Issue Editors
2. Rocky Mountain MIRECC (Mental Illness Research and Clinical Center), VISN 19 VA Health Care System, Salt Lake City, VA, USA
Interests: bipolar disorder; suicide; MR imaging; neurocircuitry; traumatic brain injury; neurocognition
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2. Rocky Mountain MIRECC (Mental Illness Research and Clinical Center), VISN 19 VA Health Care System, Salt Lake City, VA, USA
Interests: translational neuroimaging; mechanistic; clinical trials; mood disorders; brain bioenergetics; veterans; children; suicide
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2. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
Interests: biomarkers; bipolar depression; augmentation treatments; clinical trials; pharmacogenomics
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2. Rocky Mountain MIRECC (Mental Illness Research and Clinical Center), VISN 19 VA Health Care System, Salt Lake City, VA, USA
Interests: magnetic resonance spectroscopy; brain bioenergetics; mood disorders; drug abuse disorders; natural products; novel treatment interventions
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Interests: neuroscience; clinical psychiatry; neuroimaging; psychotic disorders
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Special Issue Information
Dear Colleagues,
This Special Issue will focus on recent advances in the use of magnetic resonance imaging (MRI) for the diagnosis and pharmacological treatment of mental diseases. In recent years, the field has made extraordinary efforts to identify imaging biomarkers as potential tools to improve the prevention, diagnosis and treatment of mental diseases. For example, different studies have attempted to use neuroimaging biomarkers for treatment responses in psychiatric disorders, such as major depressive disorders, using brain volumetric magnetic resonance imaging (MRI), functional MRI (resting-state and affective tasks), diffusion tensor imaging, magnetic resonance spectroscopy, near-infrared spectroscopy and molecular imaging (i.e., positron emission tomography and single-photon emission computed tomography). Some plausible regions for therapeutic responses in major depressive disorders with their subsequent activation or structural normalization effects after treatment have emerged, namely the prefrontal cortex, the anterior cingulate cortex, hippocampus, amygdala and insula. However, issues related to sample size and differences in imagining techniques have had inconclusive findings.
Potentially, the use of neuroimaging biomarkers can be clinically useful in also being applied to new biostatistical methods, including machine learning. This integration of artificial intelligence into 1H-MRS and 31P-MRS Brain Spectroscopy data could be pivotal concerning personalized medicine. Consequently, this would allow us not only to evaluate treatment outcomes and to develop new treatment strategies enable us to tailor impactful treatment strategies to improve patients’ overall wellbeing.
In this Special Issue, we welcome preclinical and clinical studies that underscore the application of neuroimaging biomarkers in the diagnosis and treatment of mental diseases as potential biomarkers. Our aim is to provide a better understanding of the pathophysiology and effective ways to personalize treatment in mental diseases.
You may choose our Joint Special Issue in Pharmaceuticals.
Prof. Dr. Deborah A. Yurgelun-Todd
Dr. Douglas Kondo
Dr. Nicolas A Nunez
Dr. Perry Franklin Renshaw
Prof. Dr. Dost Öngür
Guest Editors
Manuscript Submission Information
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Keywords
- neuroimaging
- biomarkers
- 1H-MRS
- 31P-MRS
- brain spectroscopy
- mood disorders
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