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Immunotherapy in Extensive-Stage Small Cell Lung Cancer

Centre Hospitalier de Université de Montreal, Montreal, QC H2X 0C1, Canada
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Curr. Oncol. 2021, 28(5), 4093-4108; https://doi.org/10.3390/curroncol28050347
Received: 16 September 2021 / Revised: 30 September 2021 / Accepted: 1 October 2021 / Published: 12 October 2021
(This article belongs to the Special Issue Current State of Immunotherapy for Lung Cancer)
Small cell lung cancer (SCLC) remains a poorly understood disease with aggressive features, high relapse rates, and significant morbidity as well as mortality, yet persistently limited treatment options. For three decades, the treatment algorithm of SCLC has been stagnant despite multiple attempts to find alternative therapeutic options that could improve responses and increase survival rates. On the other hand, immunotherapy has been a thriving concept that revolutionized treatment options in multiple malignancies, rendering previously untreatable diseases potentially curable. In extensive stage SCLC, immunotherapy significantly altered the course of disease and is now part of the treatment algorithm in the first-line setting. Nevertheless, the important questions that arise are how best to implement immunotherapy, who would benefit the most, and finally, how to enhance responses. View Full-Text
Keywords: immunotherapy; small cell lung cancer; checkpoint inhibitors; PD-1; PD-L1; CTLA-4 immunotherapy; small cell lung cancer; checkpoint inhibitors; PD-1; PD-L1; CTLA-4
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MDPI and ACS Style

El Sayed, R.; Blais, N. Immunotherapy in Extensive-Stage Small Cell Lung Cancer. Curr. Oncol. 2021, 28, 4093-4108. https://doi.org/10.3390/curroncol28050347

AMA Style

El Sayed R, Blais N. Immunotherapy in Extensive-Stage Small Cell Lung Cancer. Current Oncology. 2021; 28(5):4093-4108. https://doi.org/10.3390/curroncol28050347

Chicago/Turabian Style

El Sayed, Rola, and Normand Blais. 2021. "Immunotherapy in Extensive-Stage Small Cell Lung Cancer" Current Oncology 28, no. 5: 4093-4108. https://doi.org/10.3390/curroncol28050347

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