Contrast-Enhanced Imaging for Breast Cancer Detection and Management

Dear Colleagues,

Breast cancer remains one of the most frequent and impactful diseases affecting women worldwide. Recent advancements in contrast-enhanced imaging techniques are transforming its detection, characterization, and overall management. This Special Issue will focus on the evolving role of contrast-enhanced modalities—including mammography, magnetic resonance imaging and ultrasound—in improving diagnostic accuracy, guiding biopsy and treatment, and enabling personalized approaches to care.

Contrast-enhanced mammography is emerging as a powerful and accessible tool, combining anatomical and functional imaging to enhance lesion detection, especially in dense breast tissue and ambiguous findings. Its expanding use in preoperative staging, contrast-enhanced mammography-guided biopsy, and integration with Artificial Intelligence and radiomics underscores its growing clinical relevance. Meanwhile, breast magnetic resonance imaging remains a cornerstone for prognostic stratification and treatment planning, although its effectiveness is influenced by both patient- and center-specific factors.

We invite original research, systematic reviews, and clinical studies exploring the technical innovations, diagnostic performance, comparative analyses, and cost-effectiveness of contrast-enhanced imaging. Special attention will be given to the role of radiomics and Artificial Intelligence applications in disease prediction, workflow optimization, and multidisciplinary care models.

This Special Issue aims to provide a comprehensive overview of how contrast-enhanced imaging is reshaping breast cancer management.

Dr. Enida Bufi
Dr. Alejandro Martin Sanchez
Dr. Matteo Sammarra
Dr. Angela Bucaro
Guest Editors

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