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Children
Special Issues
Sepsis in Pediatrics: Present Status and Challenges for the Future
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Sepsis in Pediatrics: Present Status and Challenges for the Future

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Allergy and Immunology".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 1262

Special Issue Editor

Dr. Otilia Elena Frăsinariu

E-Mail Website
Guest Editor
Mother and Child Department, University of Medicine and Pharmacy Grigore T. Popa Iasi, Romania Emergency Clinical Hospital for Children “St. Maria”, 700309 Iasi, Romania
Interests: intensive care; epidemiology; anti-infective agents
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Sepsis is a life-threatening condition triggered by the body's extreme response to infection that can affect infants, children, and adolescents and is a significant cause of morbidity and mortality in this population.

This Special Issue, "Sepsis in Pediatrics: Present Status and Challenges for the Future", aims to present a comprehensive overview of the latest research, clinical guidelines, and expert insights to improve the diagnosis and management of sepsis in pediatric patients. By addressing the unique challenges associated with pediatric sepsis and highlighting evidence-based strategies for optimizing care, this Special Issue aims to enhance outcomes and reduce the burden of sepsis-related morbidity and mortality in children. Furthermore, it will highlight the importance of a multidisciplinary approach to managing pediatric sepsis, emphasizing collaboration between pediatricians, intensivists, infectious disease specialists, nurses, and other healthcare professionals. Our goal is to discuss strategies for optimizing care delivery, including the use of protocols and guidelines, as well as the integration of technological advances to enhance the early detection and monitoring of sepsis in children.

Dr. Otilia Elena Frăsinariu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • childhood sepsis
  • life-threatening organ dysfunction
  • septic shock
  • sepsis-induced immunosuppression
  • immunodeficiency
  • neonatal sepsis

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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18 pages, 2872 KB  
Systematic Review
Pathogen Profiles and Antimicrobial Resistance Patterns of Neonatal Sepsis in the Gulf Cooperation Council: A Systematic Review
by Razique Anwer, Hassan Al-shehri, Musab Alsulami, Ziyad Alsulami, Faisal Alzkari, Nawaf Alshaalan, Nawaf Almutairi, Abdullah Saleh Albalawi, Khalid Alshammari, Abdulelah F. Alshehri, Nawaf Alzahrani, Ibrahim A. Alamer, Albaraa Alotaibi and Meshal Alzakari
Children 2025, 12(11), 1475; https://doi.org/10.3390/children12111475 - 1 Nov 2025
Viewed by 1047
Abstract
Background: Neonatal sepsis (NS) is a life-threatening condition in newborns, which is an infectious process with a systemic inflammatory reaction to bacterial, viral, or fungal infection acquired in the first 28 days of life. Methods: This study examines the major pathogens causing neonatal [...] Read more.
Background: Neonatal sepsis (NS) is a life-threatening condition in newborns, which is an infectious process with a systemic inflammatory reaction to bacterial, viral, or fungal infection acquired in the first 28 days of life. Methods: This study examines the major pathogens causing neonatal sepsis in the Gulf Cooperation Council (GCC) and their resistance patterns to antimicrobial agents. We utilized the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to develop this systematic review to follow a systematic and transparent process. The comprehensive literature review was done in several national and global databases, which include PubMed, Scopus, Google Scholar, Embase, and Cochrane Library. The key words inserted in the search strategy were “neonatal sepsis,” “late-onset sepsis,” “early-onset sepsis,” and “Gulf Cooperation Council (GCC),” and the keywords of antimicrobial resistance and pathogens were used: “antimicrobial drug resistance” and “pathogens.” Only articles published from January 1983 to January 2025 were included for screening. Results: The final count of the articles that fit the inclusion criteria is 54, and 5177 neonatal sepsis cases’ data have been identified. The most common pathogens were coagulase-negative staphylococci (CoNS) and Klebsiella spp., which caused 17.4 percent (901 cases) and 15.9 percent (825 cases) of neonatal sepsis, respectively. Coagulase-negative staphylococci (CoNS) were the most resistant, especially to oxacillin and erythromycin. The most isolated pathogens among Gram-negative spp. were Klebsiella spp., which showed a resistance to ampicillin, amoxicillin, and ceftriaxone. Conclusions: The bacterial isolates had a diversity of antimicrobial resistance, stressing the necessity of continuous hospital surveillance. Sophisticated diagnostic methods and well-designed research are necessary, especially in areas characterized by high rates of neonatal mortality, to determine the prevalence of neonatal sepsis, risk factors, and clinical outcomes. Full article
(This article belongs to the Special Issue Sepsis in Pediatrics: Present Status and Challenges for the Future)
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