In Silico Models of Cell–Microenvironment Interactions in Healthy and Tumor Tissues

Dear Colleagues,

The complexity and heterogeneity of tissue microenvironment, its interactions with multiple healthy and tumorous cells, as well as dynamic changes in the microenvironment as a result of various treatments cannot be fully recreated in laboratory experiments but can be addressed by in silico modeling. Mathematical models, by their nature, are well suited to deal with multiple interdependent players and provide quantitative method to analyze such complex systems.  

In this Special Issue, we welcome papers that use in silico modeling to address interactions between healthy or tumor cells and the surrounding microenvironment, including one of more components of the tissue microenvironment: physical, such as extracellular matrix fiber structure; chemical, such as gradients of metabolites, nutrients, and waste products; cellular, such as stromal, endothelial, or immune cells; and the interstitial fluid interpenetrating the tissue structure. This Special Issue will showcase recent advances in mathematical models of cell–environment interactions.

Dr. Katarzyna A. Rejniak
Dr. Magdalena Stolarska
Dr. Gibin Powathil
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.