Animal Models for the Research of Alzheimer's Disease and Neurodegeneration

Dear Colleagues,

Alzheimer’s disease (AD) is a major healthcare burden with a large patient population. Currently there are no effective therapies to stop or slow down the progression of AD. The major challenge in this field is the lack of a better understanding of AD pathophysiology due to its multifaceted disease mechanisms. Animal models have been widely utilized in AD research to study the pathogenesis of AD and test drug efficacy at pre-clinical stages. In the past decade or so, innovative approaches have been developed including novel animal modeling technologies to better recapitulate pathological changes in AD and neurodegeneration in vivo, and to guide the preclinical development of efficacious therapies for AD.

This Special Issue will examine the currently available mouse models of AD, including both familial and sporadic AD mouse models, as well as other animal models. The development of animal models of AD-related neurodegenerative disorders will be explored as well. The pathological and behavioral phenotypes of various animal models of AD and neurodegenerative disorders will be discussed. The approaches of modeling environmental and genetic risk factors of AD in vivo in animals, as well as the selection of animal modeling for preclinical drug development in AD, will be investigated. 

You may choose our Joint Special Issue in Geriatrics.

Dr. Dongming Cai
Dr. Mariana Lemos Duarte
Guest Editors

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