Cell Therapies in Orthopaedics
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 47230
Special Issue Editors
Interests: regenerative medicine; orthopaedics; Spinal cord injury; pressure ulcers; biomarkers; prognostic/predictive modelling
Interests: orthopaedics; regenerative medicine; biomarkers; cell therapy; bioinformatics; proteomics; spinal cord injury; prognostic/predictive modelling
Special Issue Information
Dear Colleagues,
Treating neuromusculoskeletal disorders successfully using cell-based therapies and preventing or delaying the debilitating symptoms of chronic/inflammatory conditions such as osteoarthritis and rheumatoid arthritis would have a huge impact on human health in an aging worldwide population. Cell-based therapies in the orthopaedic clinical setting have existed for around 30 years and currently there are several in use or in clinical trials around the globe for the treatment of neuromusculoskeletal disorders. An improved understanding of the precise mechanisms of action for these cell-based therapies and the discovery and validation of predictive clinical indicators (including biomarkers) are priorities for the widespread translation and global application of burgeoning orthopaedic cell-based therapies.
The aim of this Special Issue is to provide the current ‘state-of-play’ in the orthopaedic cell therapy field, with a particular focus on mechanisms of action, tissue engineering approaches, in vitro systems, preclinical models, clinical trials, and predictive clinical indicators (including biomarkers), highlighting any barriers that have been identified that might hinder the translation or widespread adoption of these techniques.
Dr. Karina Theresa Wright
Dr. Charlotte Hulme
Guest Editors
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Keywords
- cell therapy
- tissue engineering
- in vitro models
- preclinical models
- clinical trials
- precision medicine
- biomarkers
- neuromusculoskeletal disorders
- orthopaedics
- arthritis
- spinal disorders
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