Adipocytes and Metabolic Health - Second Edition

Dear Colleagues,

Over the past decades, emerging evidence has accumulated to support the notion that adipose tissue is not just an inert site for lipid storage. It is also an active endocrine organ, which dynamically secrets multiple adipocyte-derived factors that exert a function on the local- and whole-body metabolism. Furthermore, adipose tissue is actively involved in a complex network of endocrine, paracrine, and autocrine signals, which influence other tissues and organs, including the brain, heart, liver, skeletal muscle, pancreas, and immune system. Adipose tissue has two types—white and brown. The adipocytes in these two types exhibit different a morphology and functions. While the white adipose tissue is the major site to store the lipids and secret adipokines/hormones, the brown adipose tissue is responsible for lipid burning and thermogenesis. During the development of obesity, adipose tissue loses its proper functions. Under the dysfunctional condition, fatty acids, together with other pathological factors, may cause cell stress, local hypoxia, and inflammation, which eventually lead to systemic insulin resistance, the hallmark of type-2 diabetes.

The primary focus of the Special Issue will be focused on a new understanding of adipose tissue biology/pathology, and its central role in the interplay with other tissues and organs. As such, the research articles and/or reviews will explore the mechanisms governing adipose tissue remodelling during obesity, and a potential link between dysfunctional adipose tissue and whole-body metabolic disorders. Findings here will therefore provide novel insights into the signalling pathways that potentially serve as targets to treat obesity and the related metabolic diseases.

Prof. Kai Sun
Prof. Dr. Jae Kim
Guest Editors

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