Special Issue "Adipocytes and Metabolic Health"
Deadline for manuscript submissions: closed (31 January 2020).
Interests: adipose tissue remodeling; brown fat activation; sympathetic innervation; lipolysis; thermogenesis; energy expenditure
Over the past decades, emerging evidence has accumulated to support the notion that adipose tissue is not just an inert site for lipid storage. It is also an active endocrine organ, which dynamically secrets multiple adipocyte-derived factors that exert a function on the local- and whole-body metabolism. Furthermore, adipose tissue is actively involved in a complex network of endocrine, paracrine, and autocrine signals, which influence other tissues and organs, including the brain, heart, liver, skeletal muscle, pancreas, and immune system. Adipose tissue has two types—white and brown. The adipocytes in these two types exhibit different a morphology and functions. While the white adipose tissue is the major site to store the lipids and secret adipokines/hormones, the brown adipose tissue is responsible for lipid burning and thermogenesis. During the development of obesity, adipose tissue loses its proper functions. Under the dysfunctional condition, fatty acids, together with other pathological factors, may cause cell stress, local hypoxia, and inflammation, which eventually lead to systemic insulin resistance, the hallmark of type-2 diabetes.
The primary focus of the Special Issue will be focused on a new understanding of adipose tissue biology/pathology, and its central role in the interplay with other tissues and organs. As such, the research articles and/or reviews will explore the mechanisms governing adipose tissue remodelling during obesity, and a potential link between dysfunctional adipose tissue and whole-body metabolic disorders. Findings here will therefore provide novel insights into the signalling pathways that potentially serve as targets to treat obesity and the related metabolic diseases.
Dr. Kai Sun
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- adipose tissue remodeling
- energy expenditure
- lipid signaling
- insulin resistance