Oncogenic Signal Transduction Processes: Regulation, Biomarkers and Therapy Targets

Dear Colleagues,

An integrated, comprehensive view of the molecules, processes and signaling pathways that are relevant in tumorigenesis is of paramount importance in cellular and molecular biomedicine. Deregulated cell signaling drives cancer. A wide variety of genetic mutations and/or transcriptional or translational alterations impacting relevant signaling pathways and partners are known to underlie tumor initiation and development. Improving our knowledge regarding these alterations in oncogenic signal transduction is essential to achieve a complete understanding of the progressive pathophysiological changes leading to cancer. A deeper characterization of these altered signaling molecules and processes should also foster the identification of new biomarkers and therapeutic targets that are instrumental for future clinical interventions against tumoral diseases. 

Publications on this subject are dispersed throughout the scientific literature. We believe that this Special Issue will provide a great opportunity to bring together, in a single place, a relevant set of papers dealing with recent data on altered signal transduction events, molecules or mechanisms that may account for the various phenotypic defects, at the genetic, metabolism or the tumor microenvironment levels, usually associated with cancer development.

This Special Issue should be useful for both researchers and students interested in cancer signaling. Aimed at providing an inclusive view of the cellular signaling alterations that occur in cancer, we invite both reviews and original articles focusing on the main cancer signaling pathways and the crosstalk among them. 

Dr. Eugenio Santos
Dr. Rosula Garcia-Navas
Dr. Alberto Fernández-Medarde
Guest Editors

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