Autophagy in Cancer Regulation
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Autophagy".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 193
Special Issue Editor
Special Issue Information
Dear Colleagues,
Autophagy is an evolutionarily conserved process responsible for maintaining cellular homeostasis by lysosomal degrading and recycling of damaged organelles, misfolded proteins, and other intracellular components. Autophagic dysregulation is implicated in the pathogenesis of various diseases, especially cancers. Autophagy modulation acts both as a tumor suppression and promoter. Autophagy regulates cell homeostasis during cancer and cell metabolism, EMT, metastasis, drug resistance, tumor microenvironment (several factors including hypoxia, inflammation, and cytokines), and cancer stemness. Recently, autophagy-based research has become a central target for cancer recurrence. Autophagy is a pivotal mechanism of cancer cell survival and the development of chemotherapeutic resistance; therefore, new approaches are warranted for its targeting.
This Special Issue majorly focuses on autophagy and cancer wiring where it covers autophagy and cancer metabolism, autophagy and EMT, autophagy dysregulation and drug resistance, cancer stemness and autophagy, autophagy and tumor microenvironment, and how autophagy targeting can counteract cancer proliferation growth and tumor recurrence. By addressing these areas, the issue aims to highlight how targeted manipulation of autophagy could offer new avenues for cancer treatment and potentially reduce tumor recurrence.
Dr. Tejinder Pal Khaket
Guest Editor
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Keywords
- autophagy
- drug resistance
- immune response: cancer stemness
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