The Endothelial Cell in Lung Inflammation

Dear Colleagues,

The current COVID-19 pandemic has placed unprecedented emphasis on better understanding the molecular mechanisms driving lung injury, a major determinant of COVID-19-related morbidity and mortality. Increased lung capillary endothelial permeability along with reduced alveolar liquid clearance capacity are major pathologic mechanisms of pulmonary edema and its life-threatening complication, the acute respiratory distress syndrome (ARDS). In addition to its well-documented role in COVID-19, ARDS is also common in other life-threatening conditions such as bacterial pneumonia, ventilator-induced lung injury, sepsis, polytrauma, chemical lung injury, etc. Thus, proper control of lung barrier function and innate immunity aided by better understanding of underlying genetic variances, ARDS-associated epigenetic alterations and interactions between endothelial, lung epithelial, and immune cells is key to developing new therapeutic approaches promoting recovery of endothelial barrier, normal lung function, and improvement of patient survival.

This Topical Collection on “The Endothelial Cell in Lung Inflammation” will showcase latest developments by leading research and clinical groups across the nation that shed the light on the complex roles of lung vascular endothelium in pathophysiology of ARDS and lung recovery. I invite topic reviews as well as full size research papers to compile this timely and important journal issue. 

I look forward to your prominent contributions.

Prof. Dr. Konstantin G Birukov
Collection Editor

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