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ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients

1
First Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10675 Athens, Greece
2
First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, Greece
3
Health Informatics Laboratory, School of Health Sciences, National and Kapodistrian University of Athens, 11527 Athens, Greece
4
Second Department of Critical Care, School of Medicine, National and Kapodistrian University of Athens, Attikon Hospital, 12462 Athens, Greece
*
Author to whom correspondence should be addressed.
Cells 2021, 10(1), 186; https://doi.org/10.3390/cells10010186
Received: 30 November 2020 / Revised: 9 January 2021 / Accepted: 14 January 2021 / Published: 19 January 2021
(This article belongs to the Special Issue The Endothelial Cell in Lung Inflammation)
Endotheliopathy is suggested to be an important feature of COVID-19 in hospitalized patients. To determine whether endotheliopathy is involved in COVID-19-associated mortality, markers of endothelial damage were assessed in critically ill COVID-19 patients upon intensive care unit (ICU) admission. Thirty-eight critically ill COVID-19 patients were included in this observational study, 10 of whom died in the ICU. Endothelial biomarkers, including soluble (s)E-selectin, sP-selectin, angiopoietin 1 and 2 (Ang-1 and Ang-2, respectively), soluble intercellular adhesion molecule 1 (sICAM-1), vascular endothelial growth factor (VEGF), soluble vascular endothelial (VE)-cadherin, and von Willebrand factor (vWf), were measured upon ICU admission. The ICU cohort was subsequently divided into survivors and non-survivors; Kaplan–Meier analysis was used to explore associations between biomarkers and survival, while receiver operating characteristic (ROC) curves were generated to determine their potential prognostic value. sE-selectin, sP-selectin, Ang-2, and sICAM-1 were significantly elevated in ICU non-survivors compared to survivors, and also associated with a higher mortality probability in the Kaplan–Meier analysis. The prognostic values of sE-selectin, Ang-2, and sICAM-1 from the generated ROC curves were greater than 0.85. Hence, we conclude that in our cohort, ICU non-survivors had higher levels of specific endothelial markers compared to survivors. Elevated levels of these markers upon ICU admission could possibly predict mortality in COVID-19. View Full-Text
Keywords: endotheliopathy; COVID-19; sE-selectin; sP-selectin; angiopoietin; sICAM-1; mortality endotheliopathy; COVID-19; sE-selectin; sP-selectin; angiopoietin; sICAM-1; mortality
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MDPI and ACS Style

Vassiliou, A.G.; Keskinidou, C.; Jahaj, E.; Gallos, P.; Dimopoulou, I.; Kotanidou, A.; Orfanos, S.E. ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients. Cells 2021, 10, 186. https://doi.org/10.3390/cells10010186

AMA Style

Vassiliou AG, Keskinidou C, Jahaj E, Gallos P, Dimopoulou I, Kotanidou A, Orfanos SE. ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients. Cells. 2021; 10(1):186. https://doi.org/10.3390/cells10010186

Chicago/Turabian Style

Vassiliou, Alice G.; Keskinidou, Chrysi; Jahaj, Edison; Gallos, Parisis; Dimopoulou, Ioanna; Kotanidou, Anastasia; Orfanos, Stylianos E. 2021. "ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients" Cells 10, no. 1: 186. https://doi.org/10.3390/cells10010186

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