Cellular Integrity under Mechanical Stress

Dear Colleagues,

In multicellular organisms, cells and tissues are exposed in different situations to a variety of mechanical cues. Mechanical force can either be a physiological stimulus or cause a stress situation, but while responses of cells to metabolic changes, oxidative stress, or heat are well investigated, much less is known about the mechanosensitive properties of cells.

Cytoskeletal systems, cell–cell as well as cell–matrix contacts, and mechanosensitive channels are among the primary sensors to detect changes in cell tension and to trigger a variety of responses. In order to maintain cellular homeostasis when cells and tissues are exposed to mechanical forces in different situations, physiological responses and stress protection include a variety of reactions, such as adaption of cell tension, force-induced protein unfolding, or the activation of signaling cascades.

With this Special Issue, we aim to bring together a collection of research articles, reviews and communications that address the subject of how cells or tissues respond to mechanical changes in their microenvironment, including molecular studies that analyze the physiological and pathophysiological parameters that help to maintain cellular integrity.

Prof. Dr. Annette Müller-Taubenberger
Guest Editor

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