Modulation of Mitochondrial Function and Cellular Metabolism Through Physical and Chemical Approaches: Mechanisms and Therapeutic Insights

Dear Colleagues,

Mitochondria are central regulators of cellular energy metabolism, redox balance, and calcium homeostasis, and serve as hubs for the biosynthesis of essential cellular components as well as for numerous signaling pathways that govern cell survival, function, and programmed death. The dysregulation of mitochondrial activity is implicated in a wide range of pathological conditions, including neurodegenerative diseases, cancer, metabolic disorders, and aging. Recent advances have highlighted the potential of physical and chemical interventions to modulate mitochondrial function and restore cellular homeostasis. Approaches such as photobiomodulation, exercise, thermal stress, and mechanical stimulation, alongside pharmacological agents that target mitochondrial biogenesis, dynamics, and oxidative phosphorylation, offer promising therapeutic avenues. Understanding the underlying mechanisms—which range from mitochondrial signaling cascades to metabolic reprogramming—is critical for translating these strategies into clinical applications. This Special Issue aims to bring together cutting-edge research and reviews on how physical and chemical means can influence mitochondrial function and cellular metabolism, with a focus on mechanistic insights and therapeutic perspectives. Contributions exploring novel modulators, experimental models, and translational approaches are highly encouraged.

Dr. Mohammad Golam Sabbir
Guest Editor

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