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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Applications of Artificial Intelligence in Thoracic Cancers
edited by Xin Li
submission deadline 30 Oct 2026 | Viewed by 219 | Submission Open
Keywords: artificial intelligence; biomarkers; lung cancer; machine learning; deep learning; cancer; real-world data; imaging
(This special issue belongs to the Section Methods and Technologies Development)
Clinical Treatment Research of Acute Myeloid Leukemia (AML)
edited by Madelyn Burkart and
submission deadline 30 Oct 2026 | Viewed by 197 | Submission Open
Keywords: acute myeloid leukemia; measurable residual disease (MRD); targeted therapy; allogeneic hematopoietic stem cell transplant (HSCT); molecular diagnostics; immunotherapy
Combination Therapies for Brain Tumors
edited by Jason H. Huang and Ekokobe Fonkem
submission deadline 31 Oct 2026 | 9 articles | Viewed by 31669 | Submission Open
Keywords: novel diagnostics; therapies; glioblastoma; meningioma; astrocytoma
(This special issue belongs to the Section Cancer Therapy)
Molecular Biology, Diagnosis and Management of Endometrial Cancer
edited by , and Thomas Vrekoussis
submission deadline 31 Oct 2026 | 5 articles | Viewed by 14622 | Submission Open
Keywords: endometrial cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies
(This special issue belongs to the Section Molecular Cancer Biology)
Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours submission deadline 31 Oct 2026 | 6 articles | Viewed by 12835 | Submission Open
Keywords: radiomics for the diagnosis, prognostication and treatment planning of solid tumours; methods, translational research and clinical applications; conventional and deep learning radiomics; interpretability of radiomics features and prediction models; image processing (including acquisition, segmentation and feature extraction); imaging methods (including CT, MRI, PET, SPECT and US)
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Combination Therapy in Lymphoma
edited by and Alberto Arribas
submission deadline 31 Oct 2026 | 4 articles | Viewed by 11923 | Submission Open
Keywords: combination therapy; non-Hodgkin lymphoma; Hodgkin lymphoma; targeted agents; antibody drug conjugates; bispecific agents; cellular therapies, immune checkpoint inhibitors and epigenetic agents
(This special issue belongs to the Section Cancer Therapy)
Surgical Treatment of Abdominal Tumors
edited by and Ioannis Baloyiannis
submission deadline 31 Oct 2026 | 4 articles | Viewed by 11562 | Submission Open
Keywords: abdominal; abdominal wall; tumors; surgery; cancer; malignancy; oncology; intraperitoneal; extraperitoneal
(This special issue belongs to the Section Clinical Research in Cancer)
Advances in the Treatment of Urological Cancer
edited by Anna Patrikidou
submission deadline 31 Oct 2026 | 4 articles | Viewed by 9006 | Submission Open
Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics
(This special issue belongs to the Section Cancer Therapy)
Oncologic Pathology: Diagnostic Challenges, Molecular Advances, and Clinical Correlations submission deadline 31 Oct 2026 | 5 articles | Viewed by 8490 | Submission Open
Keywords: solid neoplasia; predictive and prognostic biomarkers; target therapy; tumor microenvironment; molecular biology
(This special issue belongs to the Section Cancer Pathophysiology)
Advances in Cellular Heterogeneity and Plasticity in the Tumor Microenvironment submission deadline 31 Oct 2026 | 7 articles | Viewed by 8189 | Submission Open
Keywords: tumor microenvironment (TME); tumor microenvironmental heterogeneity and drug resistance; cancer cell plasticity and immune evasion; epithelial–mesenchymal transition (EMT); tumor immune context
(This special issue belongs to the Section Tumor Microenvironment)
Mesothelioma Epidemiology, Pathogenesis, Emerging Treatments and Pre-Clinical Models submission deadline 31 Oct 2026 | 3 articles | Viewed by 7615 | Submission Open
Keywords: mesothelioma; epidemiology; pathogenesis; emerging treatments; risk factors; biomarkers; surgical techniques; targeted therapies; immunotherapies; pre-clinical models
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Development of Biomarkers and Antineoplastic Drugs in Solid Tumors
edited by , Sofia Verkhovskaia and Michela Roberto
submission deadline 31 Oct 2026 | 3 articles | Viewed by 7235 | Submission Open
Keywords: solid tumors; drugs; biomarkers; immunotherapy; targeted therapy; artificial intelligence
(This special issue belongs to the Section Cancer Drug Development)
Clinical Research in Ocular Oncology
edited by Anthony B. Daniels, and
submission deadline 31 Oct 2026 | 2 articles | Viewed by 6486 | Submission Open
Keywords: ocular oncology; eye cancer; tumors; melanoma; retinoblastoma; hemangioma; hemangioblastoma; lymphoma
(This special issue belongs to the Section Clinical Research in Cancer)
Acute Myeloid Leukemia: Updates on Diagnosis, Treatment and Management submission deadline 31 Oct 2026 | 2 articles | Viewed by 6467 | Submission Open
Keywords: acute myeloid leukemia; treatment; targeted therapy; molecular profiling; resistance
(This special issue belongs to the Section Methods and Technologies Development)
From Molecular Insights to Cancer Treatments: Progress in Translational Science
edited by , Dhanir Tailor and
submission deadline 31 Oct 2026 | 3 articles | Viewed by 6015 | Submission Open
Keywords: cancer biology; therapeutics; molecular targets; translational research
(This special issue belongs to the Section Cancer Therapy)
Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 5491 | Submission Open
Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis
(This special issue belongs to the Section Cancer Therapy)
Oral Cancer and Precancerous Lesions: Advances in Diagnosis, Prognosis, and Therapy submission deadline 31 Oct 2026 | 4 articles | Viewed by 4957 | Submission Open
Keywords: potentially malignant oral disorders (PMODs); malignant transformation; oral cancer and precancerous lesions
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Artificial Intelligence in Urological Oncology: Applications in Imaging, Prognostics, and Precision Disease Management submission deadline 31 Oct 2026 | 4 articles | Viewed by 4641 | Submission Open
Keywords: artificial intelligence; machine learning; urological oncology; imaging, precision medicine; digital pathology; therapeutic decision-making
(This special issue belongs to the Section Cancer Therapy)
Stem Cell Origin of Cancers: Biological and Clinical Implications of a Unified Theory of Cancer (2nd Edition)
edited by Shi-Ming Tu, Louis L. Pisters and
submission deadline 31 Oct 2026 | 2 articles | Viewed by 4409 | Submission Open
Keywords: cancer stem cells; cancer-initiating cell; progenitor cell; epithelial; Mesenchymal transition; pluripotency; plasticity; heterogeneity; embryogenesis; stem-like; stemness
(This special issue belongs to the Section Cancer Pathophysiology)
Current Research in Pediatric Hematological Oncology submission deadline 31 Oct 2026 | 4 articles | Viewed by 4233 | Submission Open
Keywords: pediatric hematology; childhood leukemia; acute myeloid leukemia (AML); juvenile myelomonocytic leukemia (JMML); acute lymphoblastic leukemia (ALL); immunotherapy; CAR-T cell therapy; targeted therapies; translational research; survivorship; pediatric oncology models
(This special issue belongs to the Section Pediatric Oncology)
Combination Therapy for the Treatment of Breast Cancer
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 3936 | Submission Open
Keywords: breast cancer; combination therapy; targeted therapy; immunotherapy; endocrine therapy; chemotherapy; anti-body–drug conjugates; treatment resistance; biomarkers
(This special issue belongs to the Section Cancer Therapy)
Molecular Targets and Therapeutic Pathways in Cancer
edited by Ashish H. Shah and Deepa Seetharam
submission deadline 31 Oct 2026 | 3 articles | Viewed by 3543 | Submission Open
Keywords: cancer therapeutics; molecular targets; signal transduction pathways; targeted therapy; drug resistance; precision oncology; tumor microenvironment; immunotherapy; kinase inhibitors; translational cancer research
(This special issue belongs to the Section Cancer Drug Development)
Advanced Strategies in the Care of Hepatocellular Carcinoma Patients (2nd Edition) submission deadline 31 Oct 2026 | 3 articles | Viewed by 3238 | Submission Open
Keywords: hepatocellular carcinoma; hepatic resection; hepatectomy; liver resection; liver surgery; parenchymal-sparing liver surgery; intraoperative ultrasound; liver-specific magnetic resonance imaging; trans-arterial therapy; liver function; FibroScan
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Synergistic Radiotherapy and Immunotherapy in Cancer Treatment
edited by
submission deadline 31 Oct 2026 | 4 articles | Viewed by 3197 | Submission Open
Keywords: radiotherapy; immunotherapy; combination therapy; nanomedicine; immunogenic cell death; tumor microenvironment; immune checkpoint inhibitors; abscopal effect; systemic immunity; clinical trials
(This special issue belongs to the Section Cancer Therapy)
Targeted Therapies for Pediatric Nervous System Tumors
edited by and Nicole Brossier
submission deadline 31 Oct 2026 | 2 articles | Viewed by 3172 | Submission Open
Keywords: glioma; ependymoma; medulloblastoma; pediatric brain tumors; targeted therapy; MEK inhibitors; NTRK inhibitors; glioma neuroscience; diffuse intrinsic pontine glioma
(This special issue belongs to the Section Pediatric Oncology)
Cancer Cell Motility (2nd Edition) submission deadline 31 Oct 2026 | 2 articles | Viewed by 3122 | Submission Open
Keywords: cancer; EMT; invasion; metastasis; p53-related signaling; apoptosis; autophagy; cell cycle; anticancer drugs
(This special issue belongs to the Section Tumor Microenvironment)
Genetic, Epigenetic and Protein Biomarkers in Gynaecological and Breast Cancers submission deadline 31 Oct 2026 | 2 articles | Viewed by 3109 | Submission Open
Keywords: gynecological cancers; breast cancer; cancer biomarkers; genetic biomarkers; epigenetic biomarkers; protein biomarkers; microRNA (miRNA); cancer screening; early diagnosis; prognosis; disease monitoring; treatment stratification; therapeutic response; biomarker discovery; biomarker detection methods; translational research
(This special issue belongs to the Section Cancer Biomarkers)
Risk Factors of Kidney Cancer submission deadline 31 Oct 2026 | 1 articles | Viewed by 2487 | Submission Open
Keywords: prevention; survivorship; renal cell carcinoma; kidney cancer epidemiology
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Ras Signaling and Inhibitors: Strategies to Escape Resistance
edited by Gary Piazza
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2463 | Submission Open
Keywords: RAS; MAPK/AKT signaling; resistance; inhibitors; cancer
Glioma: From Intracellular Oncogenic Pathways to Targeting Therapeutic Strategies
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2458 | Submission Open
Keywords: glioma; targeted therapies; resistance mechanisms; oncogenic pathways; therapeutic resistance; combination therapies; tumor heterogeneity
(This special issue belongs to the Section Cancer Therapy)
EGFR-Tyrosine Kinase Inhibitor (EGFR-TKI) for Non-Small Cell Lung Cancer
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2455 | Submission Open
Keywords: EGFR TKIs; secondary mutations; alternative signaling pathway activation cancer progression; lung cancer
(This special issue belongs to the Section Cancer Therapy)
Improving Outcomes in Resected Colorectal Liver Metastases: Risk-Stratified Chemotherapy and Aggressive Integration of Thermal Ablation
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2368 | Submission Open
Keywords: colorectal liver metastases (CRLM); liver resection; systemic chemotherapy; recurrence-risk stratification; carcinoembryonic antigen (CEA); carbohydrate antigen 19-9 (CA19-9); circulating tumor DNA (ctDNA); RAS mutation; thermal ablation
(This special issue belongs to the Section Cancer Metastasis)
The Biomarkers of Oral Cancer
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2337 | Submission Open
Keywords: oral cancer; oral squamous cell carcinoma; oral melanoma; surgery; combination therapy; radiation therapy; immunotherapy; drug resistance; biomarker; liquid biopsy; prognosis
(This special issue belongs to the Section Cancer Biomarkers)
Evolving Paradigms in Acute Myeloid Leukemia: From Molecular Risk to Targeted Treatment
edited by Talha Badar
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2101 | Submission Open
Keywords: acute myeloid leukemia; targeted therapy; precision medicine; menin inhibitors; venetoclax; measurable residual disease (MRD); risk stratification; allogeneic hematopoietic cell transplantation; molecular profiling; AML consolidation therapy
Research and Treatment of Hepatocellular Carcinoma
edited by Chung Cheung Thomas Yau
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2095 | Submission Open
Keywords: hepatobiliary cancer; biomarker; immunotherapy; targeted therapy; combination treatments
(This special issue belongs to the Section Cancer Therapy)
Overcoming Drug Resistance: Precision Medicine Drug Therapy
edited by , Yuting Huang and Raveena Manem
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1966 | Submission Open
Keywords: drug resistance; precision medicine; molecular and cellular mechanisms; biomarker-guided therapy; genomic profiling; combination treatment; novel drug delivery system
(This special issue belongs to the Section Cancer Drug Development)
AI-Driven Advanced Radiotherapy: Towards Personalized, Predictive and Adaptive Cancer Treatment
edited by Zhen Tian and Chaoqiong Ma
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1881 | Submission Open
Keywords: radiotherapy; artificial intelligence; machine learning; deep learning; outcome prediction; treatment planning; adaptive RT; personalized RT; radiomics
(This special issue belongs to the Section Methods and Technologies Development)
Metabolism and Precision Oncology
edited by Rays H. Y. Jiang and Gloria C. Ferreira
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1826 | Submission Open
Keywords: cancer metabolism; precision oncology; tumor microenvironment; immunometabolism; metabolic reprogramming; redox biology; metabolomics; lipid metabolism; mitochondrial function; therapeutic targeting
(This special issue belongs to the Section Cancer Pathophysiology)
Pituitary Tumors: Molecular Insights, Diagnosis, and Targeted Therapy—Third Edition submission deadline 31 Oct 2026 | 1 articles | Viewed by 1603 | Submission Open
Keywords: acromegaly; adrenocorticotropic hormone; Cushing’s disease; diagnosis; growth hormone; pituitary tumor; proliferation; transcriptional factor; treatment
Precision Medicine in Hematological Malignancies: Current Insights and Future Directions
edited by Giuseppe Saglio and Mohamed Yassin
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1542 | Submission Open
Keywords: hematological malignancies; precision medicine; targeted therapy; next-generation sequencing; biomarkers; molecular profiling
(This special issue belongs to the Section Cancer Therapy)
Molecular Markers and Targeted Therapy for Hepatobiliary Tumors: 2nd Edition
edited by Masaki Kuwatani
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1522 | Submission Open
Keywords: cholangiocarcinoma; hepatocellular carcinoma; molecule; gene; chemotherapy; phototherapy
The Role of Lifestyle Choices in Cancer Risk
edited by Itunu O. Sokale, Aaron P. Thrift and
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1297 | Submission Open
Keywords: cancer risk; lifestyle; behavioral factors; outcome; cancer prevention
The Next Generation of Prognosis: Novel Biomarkers in AML and MDS
edited by , Andrija Bogdanovic and Ljubomir Jakovic
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1280 | Submission Open
Keywords: acute myeloid leukemia; myelodysplastic syndrome; biomarkers; minimal residual disease; novel prognostic factors; immune-related biomarkers; molecular targets; genomics; risk stratification
(This special issue belongs to the Section Clinical Research in Cancer)
Advances in Imaging Techniques of Molecular Oncology (2nd Edition)
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1247 | Submission Open
Keywords: cancer; oncological imaging; molecular imaging; SPECT/TC; PET/CT; PET/MRI; DWI; DCE-MRI; nanotheranostics; artificial intelligence; radiomics; theranostics
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Biliary Tract Cancer: Multidisciplinary Perspectives in Surgery, Endoscopic Management, and Epidemiology
edited by Hiroyuki Kato
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1191 | Submission Open
Keywords: biliary tract cancer; cholangiocarcinoma; gallbladder cancer; ampullary cancer; hepatobiliary surgery; ERCP; biliary drainage; epidemiology; immunotherapy; multidisciplinary treatment; translational research
Prognostic Markers in Endometrial Cancer
edited by and Maciej Jóźwik
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1167 | Submission Open
Keywords: endometrial cancer; prognostic markers; overall survival; disease-free survival; genetic markers; immunohistochemical markers; immunological markers
(This special issue belongs to the Section Cancer Biomarkers)
Non-Melanoma Skin Cancer: Promises and Challenges submission deadline 31 Oct 2026 | 1 articles | Viewed by 1095 | Submission Open
Keywords: non-melanoma skin cancer; AI; radiotherapy; immunotherapy; surgery; biomarker; technique
(This special issue belongs to the Section Cancer Therapy)
Innovations in Surgical and Management Strategies for Complex and Advanced Gastric Cancer submission deadline 31 Oct 2026 | 1 articles | Viewed by 1065 | Submission Open
Keywords: advanced gastric cancer; surgical innovation; multimodal therapy; minimally invasive gastrectomy (robotic/laparoscopic); perioperative management; immunotherapy; precision medicine; peritoneal metastasis
(This special issue belongs to the Section Clinical Research in Cancer)
Role of Myeloid Cells in the Regulation of Cancer Onset and Development
edited by Rita Campanelli
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1053 | Submission Open
Keywords: myeloid cells; myeloid-derived suppressor cells; hematological malignancies; solid cancers; inflammation; angiogenesis
(This special issue belongs to the Section Tumor Microenvironment)
Feature Papers in Section "Tumor Microenvironment" (2nd Edition)
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1022 | Submission Open
Keywords: tumor microenvironment; cancer progression; interactions; therapeutic targeting; immune response
(This special issue belongs to the Section Tumor Microenvironment)
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