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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Sphingolipids in Cancer Progression

edited by

Jeremy Hengst

submission deadline 30 Oct 2026 | Viewed by 411 | Submission Open

Keywords: sphingolipids; tumorigenesis; tumor progression; metastasis; spatial transcriptomics; spatial metabolomics; spatial proteomics; transcriptomics; metabolomics; proteomics; drug development

(This special issue belongs to the Section Molecular Cancer Biology)

Hyperthermic Intraperitoneal Chemotherapy in Oncology: Current Clinical Applications and Future Directions

edited by Konstantinos I. Votanopoulos

submission deadline 30 Oct 2026 | Viewed by 309 | Submission Open

Keywords: HIPEC; cytoreductive surgery; peritoneal surface malignancies; colorectal cancer; appendiceal neoplasms; gastric cancer; ovarian cancer; peritoneal mesothelioma; intraperitoneal chemotherapy-organoids

(This special issue belongs to the Section Cancer Therapy)

Surgical Management of Colorectal Cancer: Current Standards and Future Directions

edited by Pedro Silva-Vaz and

Marta Costa

submission deadline 30 Oct 2026 | Viewed by 295 | Submission Open

Keywords: colorectal cancer; colorectal surgery; robotic-assisted surgery; transanal surgery; organ preservation; neoadjuvant therapy; perioperative optimization; cancer imaging; artificial intelligence; multidisciplinary approach

(This special issue belongs to the Section Cancer Therapy)

Gastrointestinal Tumors: Screening and Prevention

edited by

Hans Scherübl

submission deadline 30 Oct 2026 | Viewed by 282 | Submission Open

Keywords: cancer; early detection; esophageal; gastric; pancreatic; hepatocellular; colorectal; risk stratification; endoscopy; liquid biopsy

Innovations in Pancreatic Oncology: Surgical Outcomes, Biomarkers, and Artificial Intelligence

edited by Jayasree Chakraborty and Lily Saadat

submission deadline 30 Oct 2026 | Viewed by 270 | Submission Open

Keywords: pancreatic cancer; oncology; early detection; surgical outcome; biomarkers; multi-modal data; artificial intelligenec; clinical decision support system; precision medicine

Advances in Immunotherapy, Biomarkers, and Clinical Practice in Pleural Mesothelioma and Thoracic Cancers

edited by

Mario Occhipinti

submission deadline 30 Oct 2026 | Viewed by 255 | Submission Open

Keywords: pleural mesothelioma; thoracic cancers; immunotherapy; biomarkers; immunotherapy resistance; molecular and genetic testing; precision oncology; real-world clinical practice

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Molecular Biomarkers in Human Testicular Germ Cell Tumors: Targets for Therapeutic, Diagnostic and Follow-Up Strategies

edited by

Marko Zivkovic

Uroš Bumbaširević

and

Milica Zeković

submission deadline 30 Oct 2026 | Viewed by 233 | Submission Open

Keywords: testicular germ cell tumors (TGCTs); molecular biomarkers; miRNA; liquid biopsy; circulating tumor DNA (ctDNA); diagnostic biomarkers; therapeutic targets; follow-up/surveillance

The Applications of Artificial Intelligence in Thoracic Cancers

edited by Xin Li

submission deadline 30 Oct 2026 | Viewed by 218 | Submission Open

Keywords: artificial intelligence; biomarkers; lung cancer; machine learning; deep learning; cancer; real-world data; imaging

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Treatment Research of Acute Myeloid Leukemia (AML)

edited by Madelyn Burkart and

Sara Small

submission deadline 30 Oct 2026 | Viewed by 193 | Submission Open

Keywords: acute myeloid leukemia; measurable residual disease (MRD); targeted therapy; allogeneic hematopoietic stem cell transplant (HSCT); molecular diagnostics; immunotherapy

Combination Therapies for Brain Tumors

edited by Jason H. Huang and Ekokobe Fonkem

submission deadline 31 Oct 2026 | 9 articles | Viewed by 31518 | Submission Open

Keywords: novel diagnostics; therapies; glioblastoma; meningioma; astrocytoma

(This special issue belongs to the Section Cancer Therapy)

Molecular Biology, Diagnosis and Management of Endometrial Cancer

edited by

Georgios Androutsopoulos

Georgios Michail

and Thomas Vrekoussis

submission deadline 31 Oct 2026 | 5 articles | Viewed by 14526 | Submission Open

Keywords: endometrial cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours

edited by

Francesco Bianconi

and

Barbara Palumbo

submission deadline 31 Oct 2026 | 6 articles | Viewed by 12734 | Submission Open

Keywords: radiomics for the diagnosis, prognostication and treatment planning of solid tumours; methods, translational research and clinical applications; conventional and deep learning radiomics; interpretability of radiomics features and prediction models; image processing (including acquisition, segmentation and feature extraction); imaging methods (including CT, MRI, PET, SPECT and US)

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Combination Therapy in Lymphoma

edited by

Afua Adjeiwaa Mensah

and Alberto Arribas

submission deadline 31 Oct 2026 | 4 articles | Viewed by 11815 | Submission Open

Keywords: combination therapy; non-Hodgkin lymphoma; Hodgkin lymphoma; targeted agents; antibody drug conjugates; bispecific agents; cellular therapies, immune checkpoint inhibitors and epigenetic agents

(This special issue belongs to the Section Cancer Therapy)

Surgical Treatment of Abdominal Tumors

edited by

Konstantinos Perivoliotis

and Ioannis Baloyiannis

submission deadline 31 Oct 2026 | 4 articles | Viewed by 11499 | Submission Open

Keywords: abdominal; abdominal wall; tumors; surgery; cancer; malignancy; oncology; intraperitoneal; extraperitoneal

(This special issue belongs to the Section Clinical Research in Cancer)

Advances in the Treatment of Urological Cancer

edited by Anna Patrikidou

submission deadline 31 Oct 2026 | 4 articles | Viewed by 8925 | Submission Open

Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics

(This special issue belongs to the Section Cancer Therapy)

Oncologic Pathology: Diagnostic Challenges, Molecular Advances, and Clinical Correlations

edited by

Paola Parente

and

Marco Donatello Delcuratolo

submission deadline 31 Oct 2026 | 5 articles | Viewed by 8411 | Submission Open

Keywords: solid neoplasia; predictive and prognostic biomarkers; target therapy; tumor microenvironment; molecular biology

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in Cellular Heterogeneity and Plasticity in the Tumor Microenvironment

edited by

Loredana Albonici

and

Manuel Scimeca

submission deadline 31 Oct 2026 | 7 articles | Viewed by 8013 | Submission Open

Keywords: tumor microenvironment (TME); tumor microenvironmental heterogeneity and drug resistance; cancer cell plasticity and immune evasion; epithelial–mesenchymal transition (EMT); tumor immune context

(This special issue belongs to the Section Tumor Microenvironment)

Mesothelioma Epidemiology, Pathogenesis, Emerging Treatments and Pre-Clinical Models

edited by

Francesca Pentimalli

submission deadline 31 Oct 2026 | 3 articles | Viewed by 7572 | Submission Open

Keywords: mesothelioma; epidemiology; pathogenesis; emerging treatments; risk factors; biomarkers; surgical techniques; targeted therapies; immunotherapies; pre-clinical models

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Development of Biomarkers and Antineoplastic Drugs in Solid Tumors

edited by

Rosa Falcone

, Sofia Verkhovskaia and Michela Roberto

submission deadline 31 Oct 2026 | 3 articles | Viewed by 7188 | Submission Open

Keywords: solid tumors; drugs; biomarkers; immunotherapy; targeted therapy; artificial intelligence

(This special issue belongs to the Section Cancer Drug Development)

Acute Myeloid Leukemia: Updates on Diagnosis, Treatment and Management

edited by

Francesco Lanza

and

Giovanni Marconi

submission deadline 31 Oct 2026 | 2 articles | Viewed by 6417 | Submission Open

Keywords: acute myeloid leukemia; treatment; targeted therapy; molecular profiling; resistance

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Research in Ocular Oncology

edited by Anthony B. Daniels,

Arun D. Singh

and

Jens Folke Kiilgaard

submission deadline 31 Oct 2026 | 2 articles | Viewed by 6374 | Submission Open

Keywords: ocular oncology; eye cancer; tumors; melanoma; retinoblastoma; hemangioma; hemangioblastoma; lymphoma

(This special issue belongs to the Section Clinical Research in Cancer)

From Molecular Insights to Cancer Treatments: Progress in Translational Science

edited by

Sanjay V. Malhotra

, Dhanir Tailor and

Annah Rolig

submission deadline 31 Oct 2026 | 3 articles | Viewed by 5926 | Submission Open

Keywords: cancer biology; therapeutics; molecular targets; translational research

(This special issue belongs to the Section Cancer Therapy)

Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment

edited by

Wing Keung Chan

submission deadline 31 Oct 2026 | 3 articles | Viewed by 5323 | Submission Open

Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis

(This special issue belongs to the Section Cancer Therapy)

Oral Cancer and Precancerous Lesions: Advances in Diagnosis, Prognosis, and Therapy

edited by

Maria Maddalena Marrapodi

submission deadline 31 Oct 2026 | 4 articles | Viewed by 4877 | Submission Open

Keywords: potentially malignant oral disorders (PMODs); malignant transformation; oral cancer and precancerous lesions

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Artificial Intelligence in Urological Oncology: Applications in Imaging, Prognostics, and Precision Disease Management

edited by

Sabine D. Brookman-May

submission deadline 31 Oct 2026 | 4 articles | Viewed by 4560 | Submission Open

Keywords: artificial intelligence; machine learning; urological oncology; imaging, precision medicine; digital pathology; therapeutic decision-making

(This special issue belongs to the Section Cancer Therapy)

Stem Cell Origin of Cancers: Biological and Clinical Implications of a Unified Theory of Cancer (2nd Edition)

edited by Shi-Ming Tu, Louis L. Pisters and

John F. Ward

submission deadline 31 Oct 2026 | 2 articles | Viewed by 4377 | Submission Open

Keywords: cancer stem cells; cancer-initiating cell; progenitor cell; epithelial; Mesenchymal transition; pluripotency; plasticity; heterogeneity; embryogenesis; stem-like; stemness

(This special issue belongs to the Section Cancer Pathophysiology)

Current Research in Pediatric Hematological Oncology

edited by

Santhosh Kumar Pasupuleti

and

Tzu-Chieh Ho

submission deadline 31 Oct 2026 | 4 articles | Viewed by 4136 | Submission Open

Keywords: pediatric hematology; childhood leukemia; acute myeloid leukemia (AML); juvenile myelomonocytic leukemia (JMML); acute lymphoblastic leukemia (ALL); immunotherapy; CAR-T cell therapy; targeted therapies; translational research; survivorship; pediatric oncology models

(This special issue belongs to the Section Pediatric Oncology)

Combination Therapy for the Treatment of Breast Cancer

edited by

Xin Wang

submission deadline 31 Oct 2026 | 3 articles | Viewed by 3879 | Submission Open

Keywords: breast cancer; combination therapy; targeted therapy; immunotherapy; endocrine therapy; chemotherapy; anti-body–drug conjugates; treatment resistance; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Molecular Targets and Therapeutic Pathways in Cancer

edited by Ashish H. Shah and Deepa Seetharam

submission deadline 31 Oct 2026 | 3 articles | Viewed by 3403 | Submission Open

Keywords: cancer therapeutics; molecular targets; signal transduction pathways; targeted therapy; drug resistance; precision oncology; tumor microenvironment; immunotherapy; kinase inhibitors; translational cancer research

(This special issue belongs to the Section Cancer Drug Development)

Advanced Strategies in the Care of Hepatocellular Carcinoma Patients (2nd Edition)

edited by

Matteo Donadon

and

Guido Torzilli

submission deadline 31 Oct 2026 | 3 articles | Viewed by 3190 | Submission Open

Keywords: hepatocellular carcinoma; hepatic resection; hepatectomy; liver resection; liver surgery; parenchymal-sparing liver surgery; intraoperative ultrasound; liver-specific magnetic resonance imaging; trans-arterial therapy; liver function; FibroScan

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Targeted Therapies for Pediatric Nervous System Tumors

edited by

Mohamed S. Abdelbaki

and Nicole Brossier

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3137 | Submission Open

Keywords: glioma; ependymoma; medulloblastoma; pediatric brain tumors; targeted therapy; MEK inhibitors; NTRK inhibitors; glioma neuroscience; diffuse intrinsic pontine glioma

(This special issue belongs to the Section Pediatric Oncology)

Synergistic Radiotherapy and Immunotherapy in Cancer Treatment

edited by

Xiaju Cheng

submission deadline 31 Oct 2026 | 4 articles | Viewed by 3136 | Submission Open

Keywords: radiotherapy; immunotherapy; combination therapy; nanomedicine; immunogenic cell death; tumor microenvironment; immune checkpoint inhibitors; abscopal effect; systemic immunity; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Cancer Cell Motility (2nd Edition)

edited by

Gianluca Aguiari

and

Nicoletta Bianchi

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3087 | Submission Open

Keywords: cancer; EMT; invasion; metastasis; p53-related signaling; apoptosis; autophagy; cell cycle; anticancer drugs

(This special issue belongs to the Section Tumor Microenvironment)

Genetic, Epigenetic and Protein Biomarkers in Gynaecological and Breast Cancers

edited by

Apriliana Kartikasari

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2963 | Submission Open

Keywords: gynecological cancers; breast cancer; cancer biomarkers; genetic biomarkers; epigenetic biomarkers; protein biomarkers; microRNA (miRNA); cancer screening; early diagnosis; prognosis; disease monitoring; treatment stratification; therapeutic response; biomarker discovery; biomarker detection methods; translational research

(This special issue belongs to the Section Cancer Biomarkers)

Risk Factors of Kidney Cancer

edited by

Ken Batai

and

Salvatore La Rosa

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2465 | Submission Open

Keywords: prevention; survivorship; renal cell carcinoma; kidney cancer epidemiology

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Glioma: From Intracellular Oncogenic Pathways to Targeting Therapeutic Strategies

edited by

Shilpi Singh

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2426 | Submission Open

Keywords: glioma; targeted therapies; resistance mechanisms; oncogenic pathways; therapeutic resistance; combination therapies; tumor heterogeneity

(This special issue belongs to the Section Cancer Therapy)

EGFR-Tyrosine Kinase Inhibitor (EGFR-TKI) for Non-Small Cell Lung Cancer

edited by

Francesca Iommelli

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2417 | Submission Open

Keywords: EGFR TKIs; secondary mutations; alternative signaling pathway activation cancer progression; lung cancer

(This special issue belongs to the Section Cancer Therapy)

Ras Signaling and Inhibitors: Strategies to Escape Resistance

edited by Gary Piazza

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2367 | Submission Open

Keywords: RAS; MAPK/AKT signaling; resistance; inhibitors; cancer

Improving Outcomes in Resected Colorectal Liver Metastases: Risk-Stratified Chemotherapy and Aggressive Integration of Thermal Ablation

edited by

Toru Beppu

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2329 | Submission Open

Keywords: colorectal liver metastases (CRLM); liver resection; systemic chemotherapy; recurrence-risk stratification; carcinoembryonic antigen (CEA); carbohydrate antigen 19-9 (CA19-9); circulating tumor DNA (ctDNA); RAS mutation; thermal ablation

(This special issue belongs to the Section Cancer Metastasis)

The Biomarkers of Oral Cancer

edited by

Yasumasa Kakei

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2326 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; oral melanoma; surgery; combination therapy; radiation therapy; immunotherapy; drug resistance; biomarker; liquid biopsy; prognosis

(This special issue belongs to the Section Cancer Biomarkers)

Research and Treatment of Hepatocellular Carcinoma

edited by Chung Cheung Thomas Yau

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2061 | Submission Open

Keywords: hepatobiliary cancer; biomarker; immunotherapy; targeted therapy; combination treatments

(This special issue belongs to the Section Cancer Therapy)

Evolving Paradigms in Acute Myeloid Leukemia: From Molecular Risk to Targeted Treatment

edited by Talha Badar

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2027 | Submission Open

Keywords: acute myeloid leukemia; targeted therapy; precision medicine; menin inhibitors; venetoclax; measurable residual disease (MRD); risk stratification; allogeneic hematopoietic cell transplantation; molecular profiling; AML consolidation therapy

Overcoming Drug Resistance: Precision Medicine Drug Therapy

edited by

Chenyu Sun

, Yuting Huang and Raveena Manem

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1913 | Submission Open

Keywords: drug resistance; precision medicine; molecular and cellular mechanisms; biomarker-guided therapy; genomic profiling; combination treatment; novel drug delivery system

(This special issue belongs to the Section Cancer Drug Development)

AI-Driven Advanced Radiotherapy: Towards Personalized, Predictive and Adaptive Cancer Treatment

edited by Zhen Tian and Chaoqiong Ma

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1855 | Submission Open

Keywords: radiotherapy; artificial intelligence; machine learning; deep learning; outcome prediction; treatment planning; adaptive RT; personalized RT; radiomics

(This special issue belongs to the Section Methods and Technologies Development)

Metabolism and Precision Oncology

edited by Rays H. Y. Jiang and Gloria C. Ferreira

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1787 | Submission Open

Keywords: cancer metabolism; precision oncology; tumor microenvironment; immunometabolism; metabolic reprogramming; redox biology; metabolomics; lipid metabolism; mitochondrial function; therapeutic targeting

(This special issue belongs to the Section Cancer Pathophysiology)

Pituitary Tumors: Molecular Insights, Diagnosis, and Targeted Therapy—Third Edition

edited by

Kazunori Kageyama

and

Mitsuru Nishiyama

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1556 | Submission Open

Keywords: acromegaly; adrenocorticotropic hormone; Cushing’s disease; diagnosis; growth hormone; pituitary tumor; proliferation; transcriptional factor; treatment

Precision Medicine in Hematological Malignancies: Current Insights and Future Directions

edited by Giuseppe Saglio and Mohamed Yassin

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1529 | Submission Open

Keywords: hematological malignancies; precision medicine; targeted therapy; next-generation sequencing; biomarkers; molecular profiling

(This special issue belongs to the Section Cancer Therapy)

Molecular Markers and Targeted Therapy for Hepatobiliary Tumors: 2nd Edition

edited by Masaki Kuwatani

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1448 | Submission Open

Keywords: cholangiocarcinoma; hepatocellular carcinoma; molecule; gene; chemotherapy; phototherapy

The Role of Lifestyle Choices in Cancer Risk

edited by Itunu O. Sokale, Aaron P. Thrift and

Xiaotao Zhang

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1278 | Submission Open

Keywords: cancer risk; lifestyle; behavioral factors; outcome; cancer prevention

The Next Generation of Prognosis: Novel Biomarkers in AML and MDS

edited by

Marijana Virijevic

, Andrija Bogdanovic and Ljubomir Jakovic

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1251 | Submission Open

Keywords: acute myeloid leukemia; myelodysplastic syndrome; biomarkers; minimal residual disease; novel prognostic factors; immune-related biomarkers; molecular targets; genomics; risk stratification

(This special issue belongs to the Section Clinical Research in Cancer)

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