Targeting the Hypoxic Axis: HIF Signaling and Therapeutic Resistance in the Tumor Microenvironment
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 272
Editors
Interests: hypoxia; tumor immune response; natural killer; cytotoxic T lymphocytes; autophagy; cancer immunotherapy; immune checkpoint blockades; tumor immune landscape; tumor cell plasticity
Special Issues, Collections and Topics in MDPI journals
Interests: hypoxia-inducible factors (HIF-1α, HIF-2α, HIF-3α); tumor microenvironment (TME) plasticity; metabolic reprogramming; immune evasion and checkpoint resistance; angiogenesis; HIF inhibitors (e.g., belzutifan, small molecules); hypoxia-induced autophagy; multidrug resistance (MDR1) mechanisms; targeted cancer therapy
Special Issue Information
Dear Colleagues,
Hypoxia is a hallmark of all solid tumors and a critical driver of tumor progression, therapeutic resistance, and immune evasion. These effect are largely mediated through the stabilization and activation of hypoxia-inducible factors (HIFs), which act as central transcriptional regulators enabling cancer cells and stromal components to adapt to low-oxygen conditions within the tumor microenvironment.
This Special Issue aims to highlight recent advances in our understanding of the molecular mechanisms involving HIF signaling and its divers roles in shaping the tumor microenvironment and anti-tumor immune response. We invite original research articles and comprehensive reviews that explore HIF-mediated mechanisms on tumor cell biology, the impact of hypoxia on tumor–immune interactions, and the development of therapeutic strategies targeting hypoxic tumors. Particular emphasis is placed on innovative combination approaches, such as integration with immunotherapy, designed to overcome hypoxia-driven resistance. By bridging fundamental mechanistic insights with translational and clinical perspectives, this Special Issue seeks to stimulate new concepts and redefine therapeutic strategies for hypoxic-driven malignancies.
Dr. Bassam Janji
Dr. Ruize Gao
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hypoxia-inducible factors (HIFs)
- tumor microenvironment
- hypoxia signaling
- therapeutic resistance
- cancer metabolism
- angiogenesis
- immune evasion
- targeted cancer therapy
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