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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Navigating Therapeutic Resistance in Lung Cancer

edited by

Luca Grumolato

submission deadline 15 Oct 2026 | Viewed by 246 | Submission Open

Keywords: non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immune therapy; immune checkpoint inhibitors; drug persister cells; resistance; drug tolerance

(This special issue belongs to the Section Cancer Therapy)

A Renewed Understanding of Tumor Growth Modulation by Tumor Necrosis Factor (TNF)-Associated Pathways

edited by Chandra Shekhar Boosani

submission deadline 15 Oct 2026 | Viewed by 201 | Submission Open

Keywords: tumor; inflammation; epigenetics; immune system; inhibitors

(This special issue belongs to the Section Molecular Cancer Biology)

Neuroradiology of Brain Tumors: Radiomics Features and Imaging Technologies

edited by Harpreet Hyare

submission deadline 15 Oct 2026 | Viewed by 197 | Submission Open

Keywords: MRI; radiomics; PET; sodium; perfusion; diffusion; glioma; pediatrics; machine learning

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Role of Digital Platforms in Transforming Cancer Surgery and Patient Care

edited by Sang-ho Jeong and

Jae-seok Min

submission deadline 16 Oct 2026 | 1 articles | Viewed by 1068 | Submission Open

Keywords: digital health platforms; surgical oncology; minimally invasive surgery; patient care management

Diagnosis and Therapy in Urothelial Cancer

edited by

Giuseppe Palermo

submission deadline 20 Oct 2026 | 4 articles | Viewed by 4648 | Submission Open

Keywords: urothelial cancer; bladder cancer; biomarkers; robotic surgery; immunotherapy; upper tract urothelial carcinoma

(This special issue belongs to the Section Cancer Therapy)

Thyroid Cancer Recurrence: Integrating Surgical, Clinical, and Translational Research

edited by

Nikola Slijepcevic

and Ioannis Koutelidakis

submission deadline 20 Oct 2026 | 2 articles | Viewed by 3057 | Submission Open

Keywords: thyroid cancer; recurrence; surgery; clinical management; aggressive subtypes; rare subtypes; biomarkers; imaging; translational research; targeted therapy

(This special issue belongs to the Section Clinical Research in Cancer)

Advancing Precision Oncology: From Biomarker Discovery to Clinical Validation

edited by

Manoj Pandey

and

Ruhi Dixit

submission deadline 20 Oct 2026 | 1 articles | Viewed by 721 | Submission Open

Keywords: precision medicine; biomarkers; clinical translation; medical oncology; liquid biopsy

(This special issue belongs to the Section Cancer Biomarkers)

Locally Advanced and Recurrent Pelvic Malignancy

edited by Paul Anthony Sutton

submission deadline 20 Oct 2026 | 1 articles | Viewed by 464 | Submission Open

Keywords: pelvic malignancy; locally advanced; recurrent; treament; translational research

The Future of Precision Radiotherapy for Cancer: Technology, Optimization, and Clinical Integration

edited by Thomas J. Fitzgerald

submission deadline 20 Oct 2026 | Viewed by 412 | Submission Open

Keywords: radiation; proton; photon; brachytherapy

(This special issue belongs to the Section Methods and Technologies Development)

The Robotic Revolution in Endometrial Cancer: Advancing Surgical Staging and Patient Care

edited by Roberto Berretta

submission deadline 20 Oct 2026 | Viewed by 379 | Submission Open

Keywords: endometrial cancer; robotic surgery; minimally invasive surgery; gynecologic oncology; surgical innovation; obesity; surgical staging; uterine cancer; lymphadenectomy; sentinel node mapping

(This special issue belongs to the Section Cancer Therapy)

Discovery of Novel Therapeutic Targets in Multiple Myeloma

edited by

Hiroshi Handa

submission deadline 23 Oct 2026 | Viewed by 260 | Submission Open

Keywords: multiple myeloma; therapeutic target; immunotherapy; drug resistance

Radiation Therapy for Brain Tumors

edited by

Jim Zhong

submission deadline 25 Oct 2026 | 4 articles | Viewed by 16081 | Submission Open

Keywords: radiosurgery; hypofractionated radiosurgery; spectroscopic MRI; proton radiation; image-guided radiotherapy; radiotherapy for benign tumors; radiotherapy for gliomas; gamma knife

(This special issue belongs to the Section Cancer Therapy)

Advances in Interventional Oncology in Hepatocellular Carcinoma Treatment

edited by Edward W. Lee, XiaoLi Zhu and Frank Hao

submission deadline 25 Oct 2026 | 2 articles | Viewed by 2664 | Submission Open

Keywords: hepatocellular carcinoma; interventional oncology; HCC

(This special issue belongs to the Section Cancer Therapy)

Interpretable AI and Multiomics Integration for Cancer Treatment Response Prediction: Cutting-Edge Innovations and Overcoming Challenges

edited by

Gholamreza Rafiee

submission deadline 25 Oct 2026 | Viewed by 334 | Submission Open

Keywords: machine learning; genomic language models; multiomics integration; enhancer prediction; interpretable AI; tumour stratification; deep learning; translational oncology; cancer treatment response

(This special issue belongs to the Section Methods and Technologies Development)

Skin Cancer Prevention: Strategies, Challenges and Future Directions

edited by Véronique del Marmol, Mariano Suppa, Ana-Maria Forsea and Alexander Stratigos

submission deadline 30 Oct 2026 | 8 articles | Viewed by 19472 | Submission Open

Keywords: skin cancer prevention; photoprotection; early detection; screening; epidemiology; public health; behavioral interventions; sun exposure; artificial intelligence; risk factors

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Neurofibromatosis

edited by Yunjia Chen and Yulong Fu

submission deadline 30 Oct 2026 | 2 articles | Viewed by 12453 | Submission Open

Keywords: neurofibromatosis; schwannomatosis; NF1; NF2; SMARCB1; LZTR1

Adverse Effects During Cancer Treatment

edited by Yan Gong

submission deadline 30 Oct 2026 | 4 articles | Viewed by 4213 | Submission Open

Keywords: cancer; drug-induced adverse effects; cardiotoxicity of cancer treatment; cardiotoxicity of radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Recent Advances and Strategies for the Management of CIN and HPV Eradication Strategies for the Prevention of Uterine Cervical Cancer

edited by

Masaru Sakamoto

submission deadline 30 Oct 2026 | 1 articles | Viewed by 3840 | Submission Open

Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT

Cancer Prevention and Screening: Innovations, Implementation, and Access

edited by

Jaclyn M. Hall

and Rahma S. Mkuu

submission deadline 30 Oct 2026 | 4 articles | Viewed by 3545 | Submission Open

Keywords: cancer; prevention; screening; intervention; implementation

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Neurosurgery Research on Brain Tumors

edited by

Toshihide Tanaka

submission deadline 30 Oct 2026 | 3 articles | Viewed by 2574 | Submission Open

Keywords: neuro-oncology; neurosurgical technique; brain tumors; neuroimages

Gynecological Cancers: From Bench to Bedside

edited by

Francesco Cosentino

submission deadline 30 Oct 2026 | 2 articles | Viewed by 2552 | Submission Open

Keywords: gynecologic oncology; translational research; molecular mechanisms; targeted therapy; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Epigenetic Modifiers in Cancer Treatment: Molecular Mechanisms and Clinical Applications

edited by

Appu Rathinavelu

and Umamaheswari Natarajan

submission deadline 30 Oct 2026 | 1 articles | Viewed by 2457 | Submission Open

Keywords: epigenetics; histones; DNA methylation; histone acetylations; chromatin remodeling; DNMTs (DNMT1, DNMT3A, DNMT3B); PRMTs; HDACs; miRNA; ncRNAs; lncRNA

(This special issue belongs to the Section Molecular Cancer Biology)

Translational Insights into the Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy: Integrating Mechanistic, Clinical and Therapeutic Advances

edited by Ellen M. Lavoie Smith

submission deadline 30 Oct 2026 | 3 articles | Viewed by 2355 | Submission Open

Keywords: chemotherapy-induced peripheral neuropathy; mechanisms; treatment; prevention; assessment; biomarkers

Solid Tumors, with a Focus on Urological Cancers: From Molecular Mechanisms to Predictive Biomarkers

edited by

Linhui Wang

and

Aimin Jiang

submission deadline 30 Oct 2026 | 3 articles | Viewed by 1846 | Submission Open

Keywords: solid tumors; urological cancers; tumor microenvironment; molecular mechanisms; predictive biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Clinical Research of Brachytherapy in Cancer

edited by Ludmiła Grzybowska-Szatkowska,

Paweł Cisek

and Aleksandra Kozłowska

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1360 | Submission Open

Keywords: brachytherapy; LDR; HDR; genitourinary cancers; breast cancer; skin cancer; gastrointestinal cancers; oligometastatic disease; personalized treatment and neoplasm

(This special issue belongs to the Section Clinical Research in Cancer)

Innovative Therapeutics for Breast Cancer: Advancing Clinical and Translational Research

edited by

Xuemei Xie

and Tamer Saad Kaoud

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1264 | Submission Open

Keywords: breast cancer; innovative therapeutics; translational clinical research; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; drug resistance; clinical trials; translational preclinical research

(This special issue belongs to the Section Clinical Research in Cancer)

The Current Status of Brain Tumor Imaging: 2nd Edition

edited by

Houman Sotoudeh

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1065 | Submission Open

Keywords: neuro-oncology; glioma; brain metastasis; CT scan; MRI; radiogenomics; radiomics; artificial intelligence; MR spectroscopy; MR perfusion; fMRI

(This special issue belongs to the Section Cancer Therapy)

Research and Clinical Applications of Gynecologic Cancer Detection Technologies

edited by Porfyrios Korompelis

submission deadline 30 Oct 2026 | 1 articles | Viewed by 869 | Submission Open

Keywords: gynaecological cancer; early diagnosis; artificial intelligence; novel technologies

(This special issue belongs to the Section Methods and Technologies Development)

Pathological Diagnosis and Surgical Treatment of Cholangiocarcinoma: Current Status and Novel Perspectives

edited by

Masahiko Kinoshita

submission deadline 30 Oct 2026 | 1 articles | Viewed by 684 | Submission Open

Keywords: cholangiocarcinoma; intrahepatic cholangiocarcinoma; small-duct type; large-duct type; immune checkpoint inhibitor; conversion surgery

MYC Oncogene in Cancer: Cancer Cell Intrinsic and Immune Inhibitory Functions

edited by Wadie Mahauad Fernandez and Konstantinos V. Floros

submission deadline 30 Oct 2026 | Viewed by 626 | Submission Open

Keywords: MYC oncogene; molecular oncology; immuno-oncology; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Innovations in Pancreatic Oncology: Surgical Outcomes, Biomarkers, and Artificial Intelligence

edited by Jayasree Chakraborty and Lily Saadat

submission deadline 30 Oct 2026 | 1 articles | Viewed by 601 | Submission Open

Keywords: pancreatic cancer; oncology; early detection; surgical outcome; biomarkers; multi-modal data; artificial intelligenec; clinical decision support system; precision medicine

The Role of Sphingolipids in Cancer Progression

edited by

Jeremy Hengst

submission deadline 30 Oct 2026 | Viewed by 420 | Submission Open

Keywords: sphingolipids; tumorigenesis; tumor progression; metastasis; spatial transcriptomics; spatial metabolomics; spatial proteomics; transcriptomics; metabolomics; proteomics; drug development

(This special issue belongs to the Section Molecular Cancer Biology)

Gastrointestinal Tumors: Screening and Prevention

edited by

Hans Scherübl

submission deadline 30 Oct 2026 | 1 articles | Viewed by 325 | Submission Open

Keywords: cancer; early detection; esophageal; gastric; pancreatic; hepatocellular; colorectal; risk stratification; endoscopy; liquid biopsy

Hyperthermic Intraperitoneal Chemotherapy in Oncology: Current Clinical Applications and Future Directions

edited by Konstantinos I. Votanopoulos

submission deadline 30 Oct 2026 | Viewed by 318 | Submission Open

Keywords: HIPEC; cytoreductive surgery; peritoneal surface malignancies; colorectal cancer; appendiceal neoplasms; gastric cancer; ovarian cancer; peritoneal mesothelioma; intraperitoneal chemotherapy-organoids

(This special issue belongs to the Section Cancer Therapy)

Surgical Management of Colorectal Cancer: Current Standards and Future Directions

edited by Pedro Silva-Vaz and

Marta Costa

submission deadline 30 Oct 2026 | Viewed by 306 | Submission Open

Keywords: colorectal cancer; colorectal surgery; robotic-assisted surgery; transanal surgery; organ preservation; neoadjuvant therapy; perioperative optimization; cancer imaging; artificial intelligence; multidisciplinary approach

(This special issue belongs to the Section Cancer Therapy)

Advances in Immunotherapy, Biomarkers, and Clinical Practice in Pleural Mesothelioma and Thoracic Cancers

edited by

Mario Occhipinti

submission deadline 30 Oct 2026 | Viewed by 267 | Submission Open

Keywords: pleural mesothelioma; thoracic cancers; immunotherapy; biomarkers; immunotherapy resistance; molecular and genetic testing; precision oncology; real-world clinical practice

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Molecular Biomarkers in Human Testicular Germ Cell Tumors: Targets for Therapeutic, Diagnostic and Follow-Up Strategies

edited by

Marko Zivkovic

Uroš Bumbaširević

and

Milica Zeković

submission deadline 30 Oct 2026 | Viewed by 240 | Submission Open

Keywords: testicular germ cell tumors (TGCTs); molecular biomarkers; miRNA; liquid biopsy; circulating tumor DNA (ctDNA); diagnostic biomarkers; therapeutic targets; follow-up/surveillance

The Applications of Artificial Intelligence in Thoracic Cancers

edited by Xin Li

submission deadline 30 Oct 2026 | Viewed by 227 | Submission Open

Keywords: artificial intelligence; biomarkers; lung cancer; machine learning; deep learning; cancer; real-world data; imaging

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Treatment Research of Acute Myeloid Leukemia (AML)

edited by Madelyn Burkart and

Sara Small

submission deadline 30 Oct 2026 | Viewed by 201 | Submission Open

Keywords: acute myeloid leukemia; measurable residual disease (MRD); targeted therapy; allogeneic hematopoietic stem cell transplant (HSCT); molecular diagnostics; immunotherapy

Combination Therapies for Brain Tumors

edited by Jason H. Huang and Ekokobe Fonkem

submission deadline 31 Oct 2026 | 9 articles | Viewed by 32163 | Submission Open

Keywords: novel diagnostics; therapies; glioblastoma; meningioma; astrocytoma

(This special issue belongs to the Section Cancer Therapy)

Molecular Biology, Diagnosis and Management of Endometrial Cancer

edited by

Georgios Androutsopoulos

Georgios Michail

and Thomas Vrekoussis

submission deadline 31 Oct 2026 | 5 articles | Viewed by 14846 | Submission Open

Keywords: endometrial cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours

edited by

Francesco Bianconi

and

Barbara Palumbo

submission deadline 31 Oct 2026 | 6 articles | Viewed by 13038 | Submission Open

Keywords: radiomics for the diagnosis, prognostication and treatment planning of solid tumours; methods, translational research and clinical applications; conventional and deep learning radiomics; interpretability of radiomics features and prediction models; image processing (including acquisition, segmentation and feature extraction); imaging methods (including CT, MRI, PET, SPECT and US)

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Combination Therapy in Lymphoma

edited by

Afua Adjeiwaa Mensah

and Alberto Arribas

submission deadline 31 Oct 2026 | 4 articles | Viewed by 12128 | Submission Open

Keywords: combination therapy; non-Hodgkin lymphoma; Hodgkin lymphoma; targeted agents; antibody drug conjugates; bispecific agents; cellular therapies, immune checkpoint inhibitors and epigenetic agents

(This special issue belongs to the Section Cancer Therapy)

Surgical Treatment of Abdominal Tumors

edited by

Konstantinos Perivoliotis

and Ioannis Baloyiannis

submission deadline 31 Oct 2026 | 4 articles | Viewed by 11724 | Submission Open

Keywords: abdominal; abdominal wall; tumors; surgery; cancer; malignancy; oncology; intraperitoneal; extraperitoneal

(This special issue belongs to the Section Clinical Research in Cancer)

Advances in the Treatment of Urological Cancer

edited by Anna Patrikidou

submission deadline 31 Oct 2026 | 4 articles | Viewed by 9247 | Submission Open

Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics

(This special issue belongs to the Section Cancer Therapy)

Advances in Cellular Heterogeneity and Plasticity in the Tumor Microenvironment

edited by

Loredana Albonici

and

Manuel Scimeca

submission deadline 31 Oct 2026 | 7 articles | Viewed by 8819 | Submission Open

Keywords: tumor microenvironment (TME); tumor microenvironmental heterogeneity and drug resistance; cancer cell plasticity and immune evasion; epithelial–mesenchymal transition (EMT); tumor immune context

(This special issue belongs to the Section Tumor Microenvironment)

Oncologic Pathology: Diagnostic Challenges, Molecular Advances, and Clinical Correlations

edited by

Paola Parente

and

Marco Donatello Delcuratolo

submission deadline 31 Oct 2026 | 5 articles | Viewed by 8729 | Submission Open

Keywords: solid neoplasia; predictive and prognostic biomarkers; target therapy; tumor microenvironment; molecular biology

(This special issue belongs to the Section Cancer Pathophysiology)

Mesothelioma Epidemiology, Pathogenesis, Emerging Treatments and Pre-Clinical Models

edited by

Francesca Pentimalli

submission deadline 31 Oct 2026 | 3 articles | Viewed by 7729 | Submission Open

Keywords: mesothelioma; epidemiology; pathogenesis; emerging treatments; risk factors; biomarkers; surgical techniques; targeted therapies; immunotherapies; pre-clinical models

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Development of Biomarkers and Antineoplastic Drugs in Solid Tumors

edited by

Rosa Falcone

, Sofia Verkhovskaia and Michela Roberto

submission deadline 31 Oct 2026 | 3 articles | Viewed by 7363 | Submission Open

Keywords: solid tumors; drugs; biomarkers; immunotherapy; targeted therapy; artificial intelligence

(This special issue belongs to the Section Cancer Drug Development)

Clinical Research in Ocular Oncology

edited by Anthony B. Daniels,