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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Molecular Biology of Cholangiocarcinoma
edited by and Padma-Sheela Jayaraman
submission deadline 31 Jul 2026 | Viewed by 10 | Submission Open
Keywords: cholangiocarcinoma; biliary tract cancer; early detection; targeted therapy; tumour microenvironment; spatial biology; genomics; transcriptomics; proteomics
(This special issue belongs to the Section Molecular Cancer Biology)
Artificial Intelligence in Radiation Therapy for Head and Neck Cancers: Prediction, Personalization, and Precision
edited by Meysam Tavakoli
submission deadline 31 Jul 2026 | Viewed by 5 | Submission Open
Keywords: head and neck cancer; radiation therapy; artificial intelligence  ; machine learning  ; deep learning  ; toxicity prediction  ; radiomics  ; dosiomics  ; outcome modeling  ; personalized radiotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Mitochondrial Metabolism and Cancer submission deadline 31 Jul 2026 | Viewed by 5 | Submission Open
Keywords: mitochondria; mitochondrial metabolism; cancer; bioenergetics; metabolomics; proteomics; mitochondrial dynamics; therapeutic targets; drug resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Novel Therapies in Metastatic Castration-Resistant Prostate Cancer
edited by Kathryn E. Meier
submission deadline 1 Aug 2026 | 1 articles | Viewed by 3217 | Submission Open
Keywords: signal transduction inhibitors; targeted therapies; immunotherapy; radiopharmaceuticals; PARP inhibitors; biomarker-based approaches
(This special issue belongs to the Section Cancer Therapy)
Clinical Trials and Evolving Treatment Paradigms in Urologic Cancers
edited by
submission deadline 1 Aug 2026 | Viewed by 46 | Submission Open
Keywords: urologic cancers; clinical trials; prostate cancer; bladder cancer; kidney cancer; testicular cancer; systemic therapy; meta-analysis; biomarkers; oncology innovation
(This special issue belongs to the Section Clinical Research of Cancer)
The Clinical Trials and Management of Acute Myeloid Leukemia: 2nd Edition
edited by
submission deadline 7 Aug 2026 | Viewed by 2 | Submission Open
Keywords: acute myeloid leukemia; clinical trials; translational research; targeted therapies; novel agents
(This special issue belongs to the Section Clinical Research of Cancer)
Innovations in Active Surveillance Management of Early Prostate Cancer submission deadline 8 Aug 2026 | 1 articles | Viewed by 397 | Submission Open
Keywords: prostate cancer; risk stratification; active surveillance; predictive markers; personalized management; imaging; biomarkers; clinical pathways; patient outcomes; standardizing care; attrition; cohort studies
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Targeted Therapies in Sarcomas: Overcoming Resistance and Improving Outcomes
edited by and Mohammed M. Milhem
submission deadline 8 Aug 2026 | Viewed by 27 | Submission Open
Keywords: sarcoma; targeted therapy; resistance mechanisms; combination therapy; biomarkers; precision oncology; translational research; clinical trials
(This special issue belongs to the Section Tumor Microenvironment)
Clinical Surgery for Hepato-Pancreato-Biliary (HPB) Cancer submission deadline 10 Aug 2026 | 10 articles | Viewed by 11372 | Submission Open
Keywords: pancreatic malignancies; HPB malignancies; pancreatic ductal adenocarcinoma; liver cholangiocarcinoma; HPB surgery; liver resection; pancreatic resection
(This special issue belongs to the Section Cancer Therapy)
Bridging Translational and Clinical Oncology in Gastrointestinal Cancers: Molecular Mechanisms to Therapeutic Advances submission deadline 10 Aug 2026 | Viewed by 11 | Submission Open
Keywords: gastrointestinal cancers; translational oncology; molecular mechanisms; biomarkers; immunotherapy; radiomics; precision medicine; therapeutic advances
(This special issue belongs to the Section Methods and Technologies Development)
Rare Genitourinary Cancers submission deadline 15 Aug 2026 | Viewed by 70 | Submission Open
Keywords: rare genitourinary tumors; penile cancer; testicular cancer; urethral cancer; adrenal cancer; variant histology; upper tract urothelial carcinoma; extramammary Paget’ s disease; urologic oncology; rare cancers
(This special issue belongs to the Section Clinical Research of Cancer)
Immunotherapy for Hematologic Malignancies
edited by Rajesh Ramakrishnan Nair
submission deadline 15 Aug 2026 | Viewed by 67 | Submission Open
Keywords: immune evasion; immunotherapy; CAR-T cell therapy; BiTEs; immunomodulators; checkpoint; inhibitors; bone marrow microenvironment; refractory/relapsed; drug resistance; gene editing
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Clinical Applications of Advanced MRI Technologies for Cancers
edited by
submission deadline 15 Aug 2026 | Viewed by 38 | Submission Open
Keywords: advanced MRI techniques; multiparametric imaging; quantitative biomarkers; artificial intelligence; treatment response assessment; precision oncology; radiomics; cancer diagnosis; functional imaging; molecular imaging
(This special issue belongs to the Section Methods and Technologies Development)
Rare Cancers, Diagnostic Challenges and Personalized Therapeutic Approaches in the 21st Century (2nd Edition)
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 847 | Submission Open
Keywords: rare cancer; biology; diagnosis; classification; personalized therapeutics; markers
(This special issue belongs to the Section Cancer Therapy)
Advances in Clinical, Diagnostic and Neurosurgical Management in Pediatric Neuro-Oncology
edited by and Michael Levy
submission deadline 20 Aug 2026 | Viewed by 128 | Submission Open
Keywords: neuro-oncology; brain tumors; neuroradiology; proton therapy; pediatric; neurosurgery; treatment; chemotherapy; targeted agents; molecular subtypes; immunotherapy; late effects; radiation therapy
(This special issue belongs to the Section Pediatric Oncology)
Socio-Demographic Factors and Cancer Research: 2nd Edition
edited by and Amanda N. Goldin
submission deadline 20 Aug 2026 | Viewed by 98 | Submission Open
Keywords: socio-economic disparity; cancer delivery; cancer survival; metastatic cancer; culture-specific cancer outcomes; AI; machine learning
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Contemporary Diagnosis and Management of Prostate Cancer (2nd Edition)
edited by Thomas Jang
submission deadline 22 Aug 2026 | Viewed by 44 | Submission Open
Keywords: prostate cancer; diagnosis; management; radical prostatectomy; biomarkers
(This special issue belongs to the Section Cancer Therapy)
Modern Approach to Oral Cancer submission deadline 30 Aug 2026 | 11 articles | Viewed by 38933 | Submission Open
Keywords: oral cancer; neoplasm; oral surgery oncogenesis; dentistry oral health
(This special issue belongs to the Section Cancer Therapy)
Pathology of Acute Myeloid Leukemia (AML)
edited by Olga K. Weinberg
submission deadline 30 Aug 2026 | Viewed by 1209 | Submission Open
(This special issue belongs to the Section Cancer Pathophysiology)
Proteometabolomics in Cancer submission deadline 30 Aug 2026 | Viewed by 73 | Submission Open
Keywords: proteomics; metabolomics; cancer biology; tumor microenvironment; biomarkers; therapeutics
(This special issue belongs to the Section Molecular Cancer Biology)
Tumor Suppressor and Targeted Therapy in Hepatocellular Carcinoma: From Diagnosis to Treatment (2nd Edition)
edited by , and I-Cheng Lee
submission deadline 30 Aug 2026 | Viewed by 48 | Submission Open
Keywords: tumor suppressor; targeted therapy; hepatocellular carcinoma
(This special issue belongs to the Section Tumor Microenvironment)
Long-Term Health Outcomes and Quality of Life in Survivors of Childhood Cancer submission deadline 30 Aug 2026 | Viewed by 44 | Submission Open
Keywords: acute lymphoblastic leukemia; brain tumors; childhood cancer survivors; pollutants; environment; quality of life; nutrition; chemotherapy; air and water purification
(This special issue belongs to the Section Pediatric Oncology)
Neoantigen Vaccines for Cancer Therapy
edited by Takashi Morisaki
submission deadline 30 Aug 2026 | Viewed by 4 | Submission Open
Keywords: neoantigens; vaccine; dendritic cells; cancer; immunotherapy; priming; CTL; helper T cells
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Gastrointestinal Malignancy: Epidemiology and Risk Factors
edited by Patrick Okolo and Chengu Niu
submission deadline 31 Aug 2026 | 7 articles | Viewed by 25583 | Submission Open
Keywords: gastrointestinal cancer; epidemiology; risk factors; molecular markers; genetic factors; therapeutic advancements; prevention strategies; public health; interdisciplinary approaches; clinical impact
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advancing Horizons in Colorectal Surgery: Innovative Approaches and Outcomes
edited by Petros I. Bangeas and Vasileios N. Papadopoulos
submission deadline 31 Aug 2026 | 4 articles | Viewed by 13380 | Submission Open
Keywords: colorectal surgery; postoperative pain; surgical site infections; anastomotic leaks; minimally invasive techniques; robotic surgery
(This special issue belongs to the Section Cancer Therapy)
Advancements in “Cancer Biomarkers” for 2025–2026 submission deadline 31 Aug 2026 | 7 articles | Viewed by 10364 | Submission Open
Keywords: RNA biomarkers; miRNA biomarkers; DNA biomarkers; cell-free DNA (cfDNA); protein biomarkers; metabolomic biomarkers; mutational biomarkers; circulating tumor cells (CTCs); tumor-derived extracellular vesicle (tEV) biomarkers; cellular biomarkers; imaging biomarkers; clinical biomarkers; biomarkers of drug response; biomarkers of genetic predisposition to cancer; epigenetic biomarkers; biomarkers of cancer outcomes; mass spectrometry; next-generation sequencing (NGS); flow cytometry; positron emission tomography (PET); computed tomography (CT); magnetic resonance imaging (MRI); X-rays; ultrasound; electrocardiography (ECG/EKG); endoscopy; biopsy; pulmonary function tests (PFTs); histopathology; cytopathology; immunohistochemistry (IHC); in situ hybridization (ISH); fluorescence in situ hybridization (FISH); liquid biopsy; electron microscopy; digital pathology and image analysis
(This special issue belongs to the Section Cancer Biomarkers)
Feature Review Paper Special Issue in Section Molecular Cancer Biology
edited by
submission deadline 31 Aug 2026 | 3 articles | Viewed by 7926 | Submission Open
Keywords: molecular biology; cell biology; cancer; tumor; cancer cell
(This special issue belongs to the Section Molecular Cancer Biology)
Cancer Stem Cells: The Origin of Tumor Relapse and Metastasis submission deadline 31 Aug 2026 | 2 articles | Viewed by 2950 | Submission Open
Keywords: metastasis; cancer stem cell; tumor microenvironment; tumor heterogeneity; plasticity; immune evasion; therapeutic resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Emergencies in Gastrointestinal Surgical Oncology submission deadline 31 Aug 2026 | Viewed by 505 | Submission Open
Keywords: surgical oncology; emergencies; emergency surgery; acute care surgery; palliation; futility in surgery
(This special issue belongs to the Section Clinical Research of Cancer)
CAR T-Cell Therapy and Multiple Myeloma
edited by Jo Caers
submission deadline 31 Aug 2026 | Viewed by 309 | Submission Open
Keywords: multiple myeloma; CAR-T immunotherapy; toxicity; efficacy; tumor models; safety
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Hereditary Cancer: State of the Art
edited by Joanne Ngeow, Jianbang Chiang and
submission deadline 31 Aug 2026 | Viewed by 147 | Submission Open
Keywords: hereditary cancer syndromes; inherited cancers; cancer genetics and genomics; germline variants; surveillance
(This special issue belongs to the Section Cancer Pathophysiology)
Hypoxia-Targeting Strategies to Improve Cancer Therapy Outcomes
edited by Roben Gieling and Ayse Latif
submission deadline 31 Aug 2026 | Viewed by 83 | Submission Open
Keywords: tumor hypoxia; cancer therapy resistance; hypoxia-targeted therapy; hypoxia-inducible factors (HIFs); hypoxia-activated prodrugs; oxygen-modifying agents; combination therapy; precision drug delivery; tumor microenvironment; translational cancer research
(This special issue belongs to the Section Cancer Therapy)
The Genetic Analysis and Clinical Therapy in Lung Cancer: 2nd Edition
edited by and Frullanti Elisa
submission deadline 31 Aug 2026 | 1 articles | Viewed by 74 | Submission Open
Keywords: lung cancer; biomarkers; genetic variants; innovative technologies; targeted therapy; immunotherapy; personalized therapy; survival; liquid biopsy pharmacogenomics
(This special issue belongs to the Section Cancer Therapy)
New Advances and Approaches in Thyroid Cancer
edited by and José Manuel Rodríguez
submission deadline 31 Aug 2026 | Viewed by 66 | Submission Open
Keywords: thyroid cancer; medullary thyroid cancer; papillary thyroid cancer; follicular thyroid cancer; poorly differentiated thyroid tumours; novel approaches; prognostic biomarkers; risk stratification
(This special issue belongs to the Section Cancer Therapy)
Human Carcinogens—Chemical Agents, Occupational Exposure and Health Impact
edited by Jun-Pyo Myong
submission deadline 31 Aug 2026 | Viewed by 51 | Submission Open
Keywords: occupational exposure; chemical carcinogens; risk assessment; epidemiology; biomarkers; exposure assessment; preventive strategies; workplace safety; occupational health; regulatory measures
(This special issue belongs to the Section Infectious Agents and Cancer)
CAR T Cell Therapy in Cancer: Progress and Challenges Across Solid and Hematologic Malignancies
edited by John F. Marshall and Lauren C. Cutmore
submission deadline 31 Aug 2026 | Viewed by 51 | Submission Open
Keywords: CAR-T cell therapy; adoptive cell therapy; immunotherapy; antigen escape; solid tumor; hematologic malignancies
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Tumor Microenvironment in Cancer Therapies: Supportive or Hostile? submission deadline 31 Aug 2026 | Viewed by 50 | Submission Open
Keywords: tumor microenvironment; protumor effects; antitumor effects; immune cells; stromal cells; extracellular matrix; cancer therapies
(This special issue belongs to the Section Tumor Microenvironment)
Clinical Treatment and Outcomes of Gastrointestinal Cancer
edited by Mary Linton Peters
submission deadline 31 Aug 2026 | Viewed by 46 | Submission Open
Keywords: gastrointestinal cancer; ctDNA; chemotherapy; immunotherapy; financial toxicity; clinical trial participation
(This special issue belongs to the Section Clinical Research of Cancer)
Wnt Signaling Pathway in Cancer Immunotherapy
edited by and
submission deadline 31 Aug 2026 | Viewed by 42 | Submission Open
Keywords: Wnt signaling; immunotherapy; immune cells; macrophages; T-cell; CART cells; stromal cells; tumor microenvireonment; cancers; cancer stem cells
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
The Unseen Burden: Incidence and Outcomes of Infections in Leukemia submission deadline 31 Aug 2026 | Viewed by 42 | Submission Open
Keywords: infection management; infectious risk; antimicrobial therapy; antimicrobial prophylaxis
(This special issue belongs to the Section Infectious Agents and Cancer)
Advances in the Early Diagnosis and Treatment of Gastric Cancer (2nd Edition)
edited by Sharona B. Ross
submission deadline 31 Aug 2026 | Viewed by 40 | Submission Open
Keywords: gastric cancer; tumor resection; liver tumors
(This special issue belongs to the Section Cancer Therapy)
Acute Myeloid Leukemia in Adults (2nd Edition) submission deadline 31 Aug 2026 | Viewed by 35 | Submission Open
Keywords: acute myeloid leukemia; molecular biology; treatment landscape; resistance mechanisms
(This special issue belongs to the Section Clinical Research of Cancer)
Early Detection and Strategies for Overcoming Therapy Resistance in Lung Cancer and Mesothelioma
edited by
submission deadline 31 Aug 2026 | Viewed by 31 | Submission Open
Keywords: lung cancer; mesothelioma; screening; biomarker; molecular diagnostics; resistance
(This special issue belongs to the Section Cancer Therapy)
Advances in the Multimodal Management of Pancreatic Ductal Adenocarcinoma submission deadline 31 Aug 2026 | Viewed by 2 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDAC); multimodal approach; systemic therapy; radiotherapy; targeted strategies; neoadjuvant therapy; adjuvant therapy
(This special issue belongs to the Section Cancer Therapy)
Cancer-Therapy-Related Adverse Events (2nd Edition)
edited by and Pauline Funchain
submission deadline 1 Sep 2026 | 2 articles | Viewed by 2394 | Submission Open
Keywords: cancer; cancer therapy; toxicities; adverse events
(This special issue belongs to the Section Cancer Therapy)
The Role of Minimally Invasive and Minimally Radical Surgery in Cervical and Endometrial Cancer
edited by , Marie Plante, Christophe Pomel, and Gwénaël Ferron
submission deadline 1 Sep 2026 | Viewed by 87 | Submission Open
Keywords: cervical cancer; endometrial cancer; laparoscopic surgery; minimally invasive surgery; surgical oncology; fertility-sparing surgery; non-radical surgery; conservative surgery
(This special issue belongs to the Section Cancer Therapy)
Prostatectomy Today: Surgical Advances in Prostate Cancer Management
edited by
submission deadline 1 Sep 2026 | Viewed by 46 | Submission Open
Keywords: prostate cancer; robot-assisted radical prostatectomy; robotic system; perioperative outcomes; sexual function; urinary continence; oncological outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Interventional Oncologic Therapies
edited by Edward W. Lee and
submission deadline 15 Sep 2026 | 3 articles | Viewed by 9238 | Submission Open
(This special issue belongs to the Section Cancer Therapy)
Breast Cancer: Immune Response, Immune Microenvironment, and Immunotherapy submission deadline 15 Sep 2026 | Viewed by 52 | Submission Open
Keywords: breast cancer; immune response; tumor immune microenvironment; immunotherapy resistance; intrinsic and extrinsic mechanisms; immune checkpoint inhibitors; T-cell dysfunction; cytokines; cancer vaccines; tumor immunosuppression
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Evidence-Based Care for Managing Oncologic Emergencies in Patients with Cancer submission deadline 15 Sep 2026 | Viewed by 46 | Submission Open
Keywords: oncologic emergencies; cancer; urgent; infections; adverse events; thrombosis; febrile neutropenia; pain; spinal cord compression; goals of care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
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