Pediatric/Adolescent Cancer and Exercise
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Pediatric Oncology".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 24631
Special Issue Editors
Interests: exercise and disease; exercise and molecular biology; exercise and pediatric/adolescent cancer
2. Physical Activity and Health Laboratory, Instituto de Investigación Sanitaria Hospital '12 de Octubre' ('imas12'), 28041 Madrid, Spain
Interests: exercise prescription; exercise and chronic diseases; responses and adaptations to exercise; exercise physiology
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Special Issue Information
Dear Colleagues,
There is growing evidence for a protective association of regular physical activity and the risk of many prevalent adult cancers, and even of cancer-related outcomes––including mortality––once a tumor has developed. The first biological evidence for this association was published nearly eight decades ago, when Rush and Kline showed a slower rate of tumor growth–– inoculated fibrosarcoma––in treadmill-trained mice compared to a control group with a similar calorie intake but not subjected to forced exercise (Cancer Research 1943;4:116-118). In the current millennium, a growing number of preclinical studies are providing insight into the mechanisms responsible for the antitumoral effects of exercise, particularly improved cancer immunosurveillance. This is quite an important finding because evading immune destruction is a hallmark of cancer and immunotherapy is reshaping cancer treatment. On the other hand, since Winningham published her doctoral thesis (1983) showing the benefits of cycle-ergometer exercise on the functional capacity and wellbeing of women with breast cancer, strong evidence has accumulated over the years supporting the role of exercise practice as a co-adjuvant treatment to attenuate tumor/treatment side effects (e.g., fatigue), with world experts currently endorsing ‘that people living with and beyond cancer should be as active as is possible for them’ (CA Cancer J Clin 2019 Nov;69(6):468-484).
Yet, many questions remain open, especially with regard to the great forgotten, pediatric/adolescent cancer. The tumor biology indeed differs compared to most adult malignancies (and sometime develops in the context of an immature immune system) and thus poses alternative, fascinating questions. The preventive effects of an active lifestyle are likely to be less important than in adults given the very early occurrence in life of these tumors but, on the other hand, a young survivor faces a whole lifetime of potential side effects aggravated by inactivity. In addition, affected adolescents must face cancer in a particularly challenging period of life, when nutrition and activity habits are usually poor.
This issue welcomes preclinical and clinical papers dealing with exercise effects in the entire pediatric/adolescent cancer control continuum.
Dr. Carmen Fiuza-Luces
Prof. Dr. Alejandro Lucia
Guest Editors
Manuscript Submission Information
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Keywords
- exercise
- disease
- molecular biology
- pediatric/adolescent cancer
- physical activity
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