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Cancers
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Nanoparticle-Based Strategy in Anticancer Therapy: From Basic Science to Application
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Nanoparticle-Based Strategy in Anticancer Therapy: From Basic Science to Application

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 22661

Special Issue Editors

Dr. Maciej Wnuk

E-Mail Website
Guest Editor
Department of Biotechnology, University of Rzeszow, Pigonia 1 A0, 35-310 Rzeszow, Poland
Interests: cancer cells; yeast cell biology; chromosomes; genomic instability; senescence; toxicology
Special Issues, Collections and Topics in MDPI journals
Dr. Anna Lewinska

E-Mail Website
Guest Editor
Department of Biotechnology, University of Rzeszow, Poland
Interests: cancer biology; nanotoxicology; molecular biology; in vitro systems; nutracetics; cellular senescence

Special Issue Information

Dear Colleagues,

It has already been shown that nanoparticles can be attractive in oncological medicine. Therefore, the development of novel multifunctional systems combining nanoparticles with anchored drugs is of great importance in modern theranostic applications of oncology. However, several challenges have already been identified, such as proper control over particle size distribution, morphology, surface modification, biocompatibility, stability in cell culture media or in vivo fluids, controlling target temperature, safe dosage, and other factors. Moreover, specific applications of nanoparticles in living organisms require a careful evaluation based on in vivo and in vitro systems. In this Special Issue of Cancers, we welcome reviews, new methods, original research articles, and communications that advance our understanding of nanoparticle-based strategy, to limit the number of cancer cells, including the mechanisms of action of new nanomaterials that are useful in oncology.

Dr. Maciej Wnuk
Dr. Anna Lewinska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • oncology
  • nanotechnology
  • theranostic
  • nanotoxicology
  • examples

Published Papers (5 papers)

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Review

20 pages, 13052 KiB  
Review
Role and Merits of Green Based Nanocarriers in Cancer Treatment
by Abdulrahman M. Elbagory, Rahaba Makgotso Marima and Zodwa Dlamini
Cancers 2021, 13(22), 5686; https://doi.org/10.3390/cancers13225686 - 13 Nov 2021
Cited by 9 | Viewed by 2270
Abstract
The use of nanocarriers for biomedical applications has been gaining interests from researchers worldwide for the delivery of therapeutics in a controlled manner. These “smart” vehicles enhance the dissolution and the bioavailability of drugs and enable their delivery to the target site. Taking [...] Read more.
The use of nanocarriers for biomedical applications has been gaining interests from researchers worldwide for the delivery of therapeutics in a controlled manner. These “smart” vehicles enhance the dissolution and the bioavailability of drugs and enable their delivery to the target site. Taking the potential toxicity into consideration, the incorporation of natural “green” materials, derived from plants or microbial sources, in the nanocarriers fabrication, improve their safety and biocompatibility. These green components can be used as a mechanical platform or as targeting ligand for the payload or can play a role in the synthesis of nanoparticles. Several studies reported the use of green based nanocarriers for the treatment of diseases such as cancer. This review article provides a critical analysis of the different types of green nanocarriers and their synthesis mechanisms, characterization, and their role in improving drug delivery of anticancer drugs to achieve precision cancer treatment. Current evidence suggests that green-based nanocarriers can constitute an effective treatment against cancer. Full article
(This article belongs to the Special Issue Nanoparticle-Based Strategy in Anticancer Therapy: From Basic Science to Application)
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Graphical abstract

16 pages, 1063 KiB  
Review
Lipid Nanocarriers for Hyperproliferative Skin Diseases
by Eliana B. Souto, Ana L. R. de Souza, Fernanda K. dos Santos, Elena Sanchez-Lopez, Amanda Cano, Aleksandra Zielińska, Rafał Staszewski, Jacek Karczewski, Maria P. D. Gremião and Marlus Chorilli
Cancers 2021, 13(22), 5619; https://doi.org/10.3390/cancers13225619 - 10 Nov 2021
Cited by 8 | Viewed by 2634
Abstract
Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so [...] Read more.
Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs usually have low aqueous solubility, which consequently decreases skin permeation. Thus, their incorporation in lipid nanocarriers has been proposed with the main objective to increase the effectiveness of topical treatment and reduce side effects. This manuscript aims to describe the advantages of using lipid nanoparticles and liposomes that can be used to load diversity of chemically different drugs for the treatment of HSD. Full article
(This article belongs to the Special Issue Nanoparticle-Based Strategy in Anticancer Therapy: From Basic Science to Application)
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Figure 1

22 pages, 3422 KiB  
Review
A Systematic Review of Biosynthesized Metallic Nanoparticles as a Promising Anti-Cancer-Strategy
by Anisa Andleeb, Aneeta Andleeb, Salman Asghar, Gouhar Zaman, Muhammad Tariq, Azra Mehmood, Muhammad Nadeem, Christophe Hano, Jose M. Lorenzo and Bilal Haider Abbasi
Cancers 2021, 13(11), 2818; https://doi.org/10.3390/cancers13112818 - 05 Jun 2021
Cited by 80 | Viewed by 6929
Abstract
Cancer is one of the foremost causes of death worldwide. Cancer develops because of mutation in genes that regulate normal cell cycle and cell division, thereby resulting in uncontrolled division and proliferation of cells. Various drugs have been used to treat cancer thus [...] Read more.
Cancer is one of the foremost causes of death worldwide. Cancer develops because of mutation in genes that regulate normal cell cycle and cell division, thereby resulting in uncontrolled division and proliferation of cells. Various drugs have been used to treat cancer thus far; however, conventional chemotherapeutic drugs have lower bioavailability, rapid renal clearance, unequal delivery, and severe side effects. In the recent years, nanotechnology has flourished rapidly and has a multitude of applications in the biomedical field. Bio-mediated nanoparticles (NPs) are cost effective, safe, and biocompatible and have got substantial attention from researchers around the globe. Due to their safe profile and fewer side effects, these nanoscale materials offer a promising cure for cancer. Currently, various metallic NPs have been designed to cure or diagnose cancer; among these, silver (Ag), gold (Au), zinc (Zn) and copper (Cu) are the leading anti-cancer NPs. The anticancer potential of these NPs is attributed to the production of reactive oxygen species (ROS) in cellular compartments that eventually leads to activation of autophagic, apoptotic and necrotic death pathways. In this review, we summarized the recent advancements in the biosynthesis of Ag, Au, Zn and Cu NPs with emphasis on their mechanism of action. Moreover, nanotoxicity, as well as the future prospects and opportunities of nano-therapeutics, are also highlighted. Full article
(This article belongs to the Special Issue Nanoparticle-Based Strategy in Anticancer Therapy: From Basic Science to Application)
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Figure 1

38 pages, 3245 KiB  
Review
Cancer Nanopharmaceuticals: Physicochemical Characterization and In Vitro/In Vivo Applications
by Aleksandra Zielińska, Marlena Szalata, Adam Gorczyński, Jacek Karczewski, Piotr Eder, Patrícia Severino, José M. Cabeda, Eliana B. Souto and Ryszard Słomski
Cancers 2021, 13(8), 1896; https://doi.org/10.3390/cancers13081896 - 15 Apr 2021
Cited by 14 | Viewed by 4061
Abstract
Physicochemical, pharmacokinetic, and biopharmaceutical characterization tools play a key role in the assessment of nanopharmaceuticals’ potential imaging analysis and for site-specific delivery of anti-cancers to neoplastic cells/tissues. If diagnostic tools and therapeutic approaches are combined in one single nanoparticle, a new platform called [...] Read more.
Physicochemical, pharmacokinetic, and biopharmaceutical characterization tools play a key role in the assessment of nanopharmaceuticals’ potential imaging analysis and for site-specific delivery of anti-cancers to neoplastic cells/tissues. If diagnostic tools and therapeutic approaches are combined in one single nanoparticle, a new platform called nanotheragnostics is generated. Several analytical technologies allow us to characterize nanopharmaceuticals and nanoparticles and their properties so that they can be properly used in cancer therapy. This paper describes the role of multifunctional nanoparticles in cancer diagnosis and treatment, describing how nanotheragnostics can be useful in modern chemotherapy, and finally, the challenges associated with the commercialization of nanoparticles for cancer therapy. Full article
(This article belongs to the Special Issue Nanoparticle-Based Strategy in Anticancer Therapy: From Basic Science to Application)
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24 pages, 3415 KiB  
Review
Quercetin and Its Nano-Scale Delivery Systems in Prostate Cancer Therapy: Paving the Way for Cancer Elimination and Reversing Chemoresistance
by Yaseen Hussain, Sepideh Mirzaei, Milad Ashrafizadeh, Ali Zarrabi, Kiavash Hushmandi, Haroon Khan and Maria Daglia
Cancers 2021, 13(7), 1602; https://doi.org/10.3390/cancers13071602 - 31 Mar 2021
Cited by 44 | Viewed by 5639
Abstract
Prostate cancer is the second most leading and prevalent malignancy around the world, following lung cancer. Prostate cancer is characterized by the uncontrolled growth of cells in the prostate gland. Prostate cancer morbidity and mortality have grown drastically, and intensive prostate cancer care [...] Read more.
Prostate cancer is the second most leading and prevalent malignancy around the world, following lung cancer. Prostate cancer is characterized by the uncontrolled growth of cells in the prostate gland. Prostate cancer morbidity and mortality have grown drastically, and intensive prostate cancer care is unlikely to produce adequate outcomes. The synthetic drugs for the treatment of prostate cancer in clinical practice face several challenges. Quercetin is a natural flavonoid found in fruits and vegetables. Apart from its beneficial effects, its plays a key role as an anti-cancer agent. Quercetin has shown anticancer potential, both alone and in combination. Therefore, the current study was designed to collect information from the literature regarding its therapeutic significance in the treatment of prostate cancer. Studies performed both in vitro and in vivo have confirmed that quercetin effectively prevents prostate cancer through different underlying mechanisms. Promising findings have also been achieved in clinical trials regarding the pharmacokinetics and human applications of quercetin. In the meantime, epidemiological studies have shown a negative correlation between the consumption of quercetin and the incidence of prostate cancer, and have indicated a chemopreventive effect of quercetin on prostate cancer in animal models. The major issues associated with quercetin are its low bioavailability and rapid metabolism, and these require priority attention. Chemoresistance is another main negative feature concerning prostate cancer treatment. This review highlights the chemotherapeutic effect, chemo preventive effect, and chemoresistance elimination potential of quercetin in prostate cancer. The underlying mechanisms for elimination of prostate cancer and eradication of resistance, either alone or in combination with other agents, are also discussed. In addition, the nanoscale delivery of quercetin is underpinned along with possible directions for future study. Full article
(This article belongs to the Special Issue Nanoparticle-Based Strategy in Anticancer Therapy: From Basic Science to Application)
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