The Roles of microRNA in Tumor Initiation and Development: Diagnostic and Therapeutic Potential

Dear Colleagues,

MicroRNA (miRNA) is one of the non-coding RNAs that plays important roles in gene regulation, mainly at the post-transcriptional level, and compromises a large family of approximately 20–22 small nucleotide. A number of studies have reported that miRNAs support the maintenance of biological homeostasis, and that aberrant expression of miRNAs are associated with the onset of many diseases, including cancer. This Special Issue of Cancers will firstly introduce the role of miRNAs in tumor development, and will then review their therapeutic potential for cancer therapy. The next several articles will focus on the secreted miRNAs that are packaged into the small endosome-derived vesicles called exosomes, generated from the multiple cell types, including immunocytes and cancer cells. Because secreted miRNAs also play an important role in cell-to-cell communication, they have been investigated as prognostic and diagnostic biomarkers. 

Dr. Takahiro Ochiya
Dr. Ryou-u Takahashi
Guest Editors

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