Special Issue "The Asymptomatic Version of Myeloma: MGUS and Smoldering Myeloma"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (29 February 2020).
2. Hematology Department, University Hospital of Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, Spain
3. Institute for Biomedical Research of Salamanca, Salamanca 37007, Spain
Interests: myeloma; asymptomatic myeloma; minimal residual disease; early treatment; novel drugs
All cases of multiple myeloma (MM) are preceded by precursor states termed monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). MGUS is present in approximately 3%–4% of the general population over the age of 50, and it is associated with a risk of progression to MM or related disorder at a rate of 1% per year. SMM accounts for approximately 10% of all MMs, and the risk or progression to MM is not uniform, ranging from 1% to 10% per year. Both plasma cell disorders are asymptomatic with absence of myeloma-related events, and the cutoff of serum M spike is 3 g/dl or bone marrow plasma cell infiltration of 10% for distinguishing both entities. These criteria are useful in clinical practice, and in the SMM field, some models have emerged to identify different risk subgroups of patients that lead to the proposal of clinical trials in SMM patients at high risk of progression to MM with the attempt of delaying the MM development. Positive results have so far been reported which resulted, in 2014, in the update of the diagnostic criteria for MM, including some SMM patients with an imminent risk of progression to MM identified through the presence of some biomarkers. However, in spite of these major advances, our understanding of the pathogenesis of MGUS and SMM and how they can evolve to MM remains incomplete, and emerging insights in the biology of these preneoplastic lesions and their transition to clinical malignancy are crucial to understand the biology of the disease that can potentially contribute to make clinical decisions about the optimal approach for the management of these premalignant diseases.
This Special Issue aims to deepen the mechanisms involved in the transition from MGUS and SMM to MM and how they can be incorporated to the clinical models and how this approach might impact on the management of MGUS and SMM and which patients would be candidates to preventive versus curative approaches.
Dr. María Victoria Mateos
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- Monoclonal gammopathy
- Smoldering myeloma
- Prognostic features
- Genetic abnormalities
- Immune system