Antioxidants in Cancer

Dear Colleagues,

Cellular redox homeostasis disorders are among the major players of neoplastic transformation and cancer progression. Thus, redox-active therapeutics can be used either for chemoprevention or for cancer therapy. Indeed, oxidative stress can damage the cells and induce DNA mutations responsible, among other causes, for neoplastic transformation. Hence, antioxidants can be used as chemopreventive drugs. On the other hand, compared to normal cells, cancer cells usually exhibit high basal levels of ROS, which are connected with a concomitant up regulation of antioxidant defense systems, which favor malignancy. Moreover, compared to normal cells, cancer cells have a lower tolerance to increased levels of ROS, thereby providing a plausible rationale for pro-oxidant interventions. This is a complicated topic, which can be investigated from a number of perspectives. Our final goal is the compilation of a Special Issue providing an integrated understanding of the rationale for the use of redox-active compounds as “cancer bullets” in the attempt to provide the professionals with effective concepts in the battle against cancer.

Thank you for your collaboration.

Prof. Dr. Alba Minelli
Guest Editor

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