AGC Kinases and Cancer

AGC kinases are a group of related Ser/Thr protein kinases that acquired the acronym because of the structural similarities with protein kinase A, protein kinase G and protein kinase C at their catalytic domains. There are at least sixty members in the AGC kinase family, including Akt, 3-phosphoinositide-dependent kinase 1 (PDK1), protein kinase C (PKC), S6 kinase (S6K), serum- and glucocorticoid-induced protein kinase (SGK) and Rho-associated coiled-coil containing kinase (ROCK). AGC kinases play important roles in signal transduction and cell regulation. An aberration in several members of the AGC kinase family has been associated with cancer. Many of these AGC kinases exist as several different isoforms that exhibit distinct functions. Proper targeting of AGC kinases for cancer therapy requires a thorough understanding of the structure, function and regulation of different isoforms of a particular AGC kinase and the molecular mechanisms by which they contribute to cancer.  This Special Issue focuses on the involvement of AGC kinases, especially the function of individual isoforms of a particular AGC kinase, in cancer and as potential targets for cancer therapy.

Prof. Dr. Alakananda Basu
Guest Editor

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