The Role of Rho GTPases in Cancer
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3057
Special Issue Editors
2. Mechanisms of Cancer Program, Centro de Investigación del Cáncer, CSIC-University of Salamanca, 37007 Salamanca, Spain
Interests: Rho GTPases; Vav proteins; synucleins; melanoma; drug repositioning; therapy resistance
Special Issue Information
Dear Colleagues,
The Rho family of GTPases are key molecular switches that regulate actin cytoskeletal dynamics, coordinating a wide range of cellular processes including cell migration, intracellular signaling, and cell cycle progression. Dysregulation of Rho GTPases is seen in different types of cancer and is associated with cancer progression, development of metastases, and resistance to therapies. Targeting Rho GTPase signaling emerges as a therapeutic option for cancer therapy, particularly in combination with other anticancer agents.
We are pleased to invite you to participate in this Special Issue with a high-quality article or review (including basic, translational, and clinical studies on all tumor types), highlighting the role of Rho GTPases in cancer. The Rho family of GTPases is well known for their roles in regulating cell migration, and they also contribute to a variety of other cellular responses related to cancer and metastasis development and therapy resistance acquisition. This Special Issue aims to highlight the relevance of Rho GTPases in cellular pathways leading to cancer progression, metastasis development, and resistance acquisition.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Molecular signaling controlled by Rho GTPases in cancer;
- Involvement of typical and atypical Rho GTPases in different types of cancers;
- Molecular modulators of Rho GTPases in cancer;
- Targeting Rho GTPasess for cancer treatment;
- Rho GTPases and resistance to different cancer therapies;
- Pharmacological inhibition of Rho GTPases-related pathways.
We look forward to receiving your contributions.
Dr. Mauricio A. Menacho-Márquez
Dr. Javier Robles-Valero
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Rho GTPases
- GEFs
- GAPs
- GDIs
- cancer
- metastasis
- chemotherapy resistance
- immunotherapy
- EMT
- inhibitors
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
